Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

219699

Name

UNC5B

Synonymous

UNC5H2|p53RDL1;unc-5 homolog B (C. elegans);UNC5B;unc-5 homolog B (C. elegans)

Definition

netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2

Position

10q22.1

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

PIKE(m.s.) + unc-5B-isoform1(h) <==> PIKE(m.s.):unc-5B-isoform1(h) (binding)
unc-5B-isoform1(h) + ATP --> unc-5B-isoform1(h){pY} + ADP (phosphorylation)
UNC5B(h) --> unc-5B-isoform1(h) (expression).
G-alpha-i2(m) + unc-5B(h) <==> G-alpha-i2(m):unc-5B(h) (binding)
unc-5B(h) + G-alpha-i2(m):GTP <==> unc-5B(h):G-alpha-i2(m):GTP (binding)
unc-5B(h) + PIKE(m.s.) <==> unc-5B(h):PIKE(m.s.) (binding)
UNC5B(h) --> unc-5B(h) (expression).
UNC5B(h) --> unc-5B-isoform2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

222N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
347N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 72640855 - 72642855Agilent_014791

chr10

Promoter: 72640855 - 72642855GSE27584

chr10

Promoter: 72640855 - 72642855Agilent_014791_44K


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