Entrez Gene

Basic Information
Gene ID	246
Name	ALOX15
Synonymous	arachidonate 15-lipoxygenase;ALOX15;arachidonate 15-lipoxygenase
Definition	12/15-lipoxygenase\|15-LOX\|15-lipooxygenase-1\|arachidonate 12-lipoxygenase, leukocyte-type\|arachidonate omega-6 lipoxygenase
Position	17p13.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1906G>A; p.E636K; 17:4631683-4631683	skin	malignant_melanoma	Substitution - Missense
c.1935C>T; p.D645D; 17:4631654-4631654	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1139C>T; p.P380L; 17:4635781-4635781	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1194A>C; p.E398D; 17:4633468-4633468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1194A>C; p.E398D; 17:4633468-4633468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1684C>T; p.R562W; 17:4632014-4632014	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949C>T; p.Q317*; 17:4637117-4637117	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1161+2T>C; p.?; 17:4635757-4635757	stomach	carcinoma; adenocarcinoma	Unknown
c.1397G>A; p.R466Q; 17:4633167-4633167	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1073A>T; p.Q358L; 17:4635847-4635847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1546C>T; p.P516S; 17:4632276-4632276	skin	malignant_melanoma	Substitution - Missense
c.1499G>A; p.R500Q; 17:4632902-4632902	liver	carcinoma	Substitution - Missense
c.1239T>G; p.I413M; 17:4633423-4633423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1499G>A; p.R500Q; 17:4632902-4632902	skin	malignant_melanoma	Substitution - Missense
c.1621G>A; p.A541T; 17:4632201-4632201	breast	carcinoma	Substitution - Missense
c.1265G>T; p.G422V; 17:4633299-4633299	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>A; p.E275K; 17:4637243-4637243	skin	malignant_melanoma	Substitution - Missense
c.823G>A; p.E275K; 17:4637243-4637243	skin	malignant_melanoma	Substitution - Missense
c.1161+6T>C; p.?; 17:4635753-4635753	liver	carcinoma	Unknown
c.1747T>C; p.F583L; 17:4631951-4631951	breast	carcinoma	Substitution - Missense
c.862G>A; p.V288I; 17:4637204-4637204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.I187I; 17:4638666-4638666	skin	malignant_melanoma	Substitution - coding silent
c.384G>A; p.R128R; 17:4639086-4639086	skin; arm	malignant_melanoma	Substitution - coding silent
c.1795C>T; p.R599C; 17:4631903-4631903	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.168T>C; p.Y56Y; 17:4639599-4639599	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.715G>A; p.V239M; 17:4638309-4638309	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.168T>C; p.Y56Y; 17:4639599-4639599	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	breast	carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine; colon	carcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1819G>A; p.G607S; 17:4631770-4631770	salivary_gland; submandibular	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.556G>A; p.A186T; 17:4638671-4638671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1540G>A; p.G514R; 17:4632861-4632861	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1188C>T; p.T396T; 17:4633474-4633474	skin	malignant_melanoma	Substitution - coding silent
c.1188C>T; p.T396T; 17:4633474-4633474	skin	malignant_melanoma	Substitution - coding silent
c.337G>A; p.G113S; 17:4639430-4639430	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1625C>G; p.S542C; 17:4632197-4632197	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.341G>A; p.R114H; 17:4639129-4639129	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1396C>T; p.R466W; 17:4633168-4633168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930A>G; p.K310K; 17:4637136-4637136	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015G>T; p.A339S; 17:4635905-4635905	kidney	other; neoplasm	Substitution - Missense
c.759C>T; p.F253F; 17:4638265-4638265	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.759C>T; p.F253F; 17:4638265-4638265	thyroid	other; neoplasm	Substitution - coding silent
c.1434C>T; p.I478I; 17:4632967-4632967	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - coding silent
c.354G>A; p.E118E; 17:4639116-4639116	skin	malignant_melanoma	Substitution - coding silent
c.1656T>C; p.S552S; 17:4632042-4632042	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1819G>T; p.G607C; 17:4631770-4631770	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.948C>G; p.I316M; 17:4637118-4637118	breast	carcinoma	Substitution - Missense
c.1863T>G; p.A621A; 17:4631726-4631726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1694C>T; p.P565L; 17:4632004-4632004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1949A>G; p.Y650C; 17:4631640-4631640	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1551C>G; p.V517V; 17:4632271-4632271	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.849G>A; p.G283G; 17:4637217-4637217	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1343C>T; p.A448V; 17:4633221-4633221	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1391C>T; p.A464V; 17:4633173-4633173	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1391C>T; p.A464V; 17:4633173-4633173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1241T>C; p.F414S; 17:4633421-4633421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1235G>A; p.G412E; 17:4633427-4633427	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1235G>A; p.G412E; 17:4633427-4633427	skin	malignant_melanoma	Substitution - Missense
c.1349G>A; p.R450Q; 17:4633215-4633215	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.948C>A; p.I316I; 17:4637118-4637118	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1604C>A; p.T535N; 17:4632218-4632218	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1344C>T; p.A448A; 17:4633220-4633220	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1796G>A; p.R599H; 17:4631902-4631902	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.808-1G>A; p.?; 17:4637259-4637259	skin	malignant_melanoma	Unknown
c.952-2A>G; p.?; 17:4635970-4635970	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1760C>G; p.S587C; 17:4631938-4631938	urinary_tract; bladder	carcinoma	Substitution - Missense
c.349G>T; p.G117C; 17:4639121-4639121	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1458C>T; p.D486D; 17:4632943-4632943	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1217G>A; p.G406E; 17:4633445-4633445	skin	malignant_melanoma	Substitution - Missense
c.1613G>A; p.G538D; 17:4632209-4632209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1162-2A>G; p.?; 17:4633502-4633502	thyroid	carcinoma; medullary_carcinoma	Unknown
c.314T>A; p.V105D; 17:4639453-4639453	skin	malignant_melanoma	Substitution - Missense
c.425G>A; p.G142E; 17:4638967-4638967	skin	malignant_melanoma	Substitution - Missense
c.112C>T; p.R38*; 17:4641540-4641540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1035C>T; p.C345C; 17:4635885-4635885	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1641+1G>T; p.?; 17:4632180-4632180	lung	carcinoma; adenocarcinoma	Unknown
c.1273C>T; p.H425Y; 17:4633291-4633291	skin	malignant_melanoma	Substitution - Missense
c.577G>T; p.V193F; 17:4638650-4638650	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1579C>T; p.H527Y; 17:4632243-4632243	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.895C>T; p.P299S; 17:4637171-4637171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>A; p.V100M; 17:4639469-4639469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10_18delTACCGCATC; p.Y4_I6delYRI; 17:4641634-4641642	soft_tissue; blood_vessel	angiosarcoma	Deletion - In frame
c.942G>A; p.M314I; 17:4637124-4637124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1617A>G; p.Q539Q; 17:4632205-4632205	skin	malignant_melanoma	Substitution - coding silent
c.309C>G; p.N103K; 17:4639458-4639458	thyroid	other; neoplasm	Substitution - Missense
c.856G>A; p.A286T; 17:4637210-4637210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.595G>T; p.D199Y; 17:4638632-4638632	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1373C>T; p.S458F; 17:4633191-4633191	skin	malignant_melanoma	Substitution - Missense
c.384G>C; p.R128R; 17:4639086-4639086	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.706G>T; p.A236S; 17:4638318-4638318	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1247A>G; p.Q416R; 17:4633415-4633415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.236A>G; p.N79S; 17:4639531-4639531	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1366A>G; p.K456E; 17:4633198-4633198	skin	malignant_melanoma	Substitution - Missense
c.1812G>A; p.V604V; 17:4631777-4631777	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.271G>A; p.E91K; 17:4639496-4639496	urinary_tract; bladder	carcinoma	Substitution - Missense
c.271G>A; p.E91K; 17:4639496-4639496	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.271G>A; p.E91K; 17:4639496-4639496	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1072C>T; p.Q358*; 17:4635848-4635848	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1003G>A; p.D335N; 17:4635917-4635917	skin	malignant_melanoma	Substitution - Missense
c.1172C>T; p.P391L; 17:4633490-4633490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1378T>C; p.Y460H; 17:4633186-4633186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1498C>T; p.R500*; 17:4632903-4632903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1620C>T; p.H540H; 17:4632202-4632202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.408G>A; p.R136R; 17:4639062-4639062	skin	malignant_melanoma	Substitution - coding silent
c.1455A>G; p.T485T; 17:4632946-4632946	thyroid	other; neoplasm	Substitution - coding silent
c.822C>T; p.F274F; 17:4637244-4637244	skin	malignant_melanoma	Substitution - coding silent
c.1835A>G; p.E612G; 17:4631754-4631754	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1905G>A; p.K635K; 17:4631684-4631684	skin; nipple	malignant_melanoma	Substitution - coding silent
c.1847G>A; p.G616D; 17:4631742-4631742	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.547G>A; p.A183T; 17:4638680-4638680	skin	malignant_melanoma	Substitution - Missense
c.1056C>A; p.F352L; 17:4635864-4635864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1783C>T; p.Q595*; 17:4631915-4631915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1516G>A; p.G506R; 17:4632885-4632885	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1516G>A; p.G506R; 17:4632885-4632885	pancreas	carcinoma	Substitution - Missense

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]