Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

26524

Name

LATS2

Synonymous

large tumor suppressor kinase 2;LATS2;large tumor suppressor kinase 2

Definition

LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|kinase phosphorylated during mitosis protein|large tumor suppressor homolog 2|serine/threonine kinase KPM|serine/threonine-protein kinase LATS2|serine/threonine-pr

Position

13q12.11

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.166G>T; p.D56Y; 13:21045861-21045861

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.949C>T; p.H317Y; 13:20988831-20988831

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.3160C>T; p.R1054*; 13:20974977-20974977

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1437G>C; p.P479P; 13:20988343-20988343

 thyroidother; neoplasmSubstitution - coding silent

c.2642C>T; p.A881V; 13:20981489-20981489

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2993A>G; p.D998G; 13:20975144-20975144

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1800C>T; p.Y600Y; 13:20987980-20987980

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.486C>T; p.L162L; 13:20989294-20989294

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.341A>G; p.Q114R; 13:21045686-21045686

 livercarcinomaSubstitution - Missense

c.341A>G; p.Q114R; 13:21045686-21045686

 livercarcinomaSubstitution - Missense

c.2521C>T; p.L841F; 13:20981610-20981610

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1436_1437insGGGGCG; p.P479_A480insGR; 13:20988343-20988344

 pancreascarcinoid-endocrine_tumour; islet_cellInsertion - In frame

c.1637C>T; p.A546V; 13:20988143-20988143

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2028C>T; p.I676I; 13:20983678-20983678

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.821C>T; p.S274F; 13:20988959-20988959

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.573C>T; p.Y191Y; 13:20989207-20989207

 central_nervous_system; braingliomaSubstitution - coding silent

c.2707C>A; p.L903I; 13:20979756-20979756

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1241C>T; p.P414L; 13:20988539-20988539

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.978C>T; p.H326H; 13:20988802-20988802

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1098C>T; p.S366S; 13:20988682-20988682

 skinmalignant_melanomaSubstitution - coding silent

c.623C>T; p.P208L; 13:20989157-20989157

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.272C>T; p.S91L; 13:21045755-21045755

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.741G>T; p.P247P; 13:20989039-20989039

 pancreascarcinomaSubstitution - coding silent

c.272C>T; p.S91L; 13:21045755-21045755

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2882G>A; p.R961Q; 13:20975255-20975255

 livercarcinomaSubstitution - Missense

c.1548G>A; p.P516P; 13:20988232-20988232

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.98C>T; p.S33L; 13:21045929-21045929

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.2308T>C; p.F770L; 13:20983398-20983398

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1361C>T; p.P454L; 13:20988419-20988419

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2407G>T; p.G803C; 13:20983299-20983299

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2562G>A; p.L854L; 13:20981569-20981569

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.3045C>T; p.S1015S; 13:20975092-20975092

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.3045C>T; p.S1015S; 13:20975092-20975092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.3045C>T; p.S1015S; 13:20975092-20975092

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.3045C>T; p.S1015S; 13:20975092-20975092

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.228C>T; p.A76A; 13:21045799-21045799

 livercarcinomaSubstitution - coding silent

c.228C>T; p.A76A; 13:21045799-21045799

 livercarcinomaSubstitution - coding silent

c.3261C>T; p.Y1087Y; 13:20974876-20974876

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2792C>T; p.T931M; 13:20975345-20975345

 bone; fibulaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1673G>A; p.R558H; 13:20988107-20988107

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2164G>T; p.E722*; 13:20983542-20983542

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1615G>C; p.G539R; 13:20988165-20988165

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.2741delT; p.L914fs*10; 13:20979722-20979722

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1954G>T; p.E652*; 13:20983752-20983752

 breastcarcinomaSubstitution - Nonsense

c.648C>T; p.F216F; 13:20989132-20989132

 skinmalignant_melanomaSubstitution - coding silent

c.2449A>G; p.R817G; 13:20983257-20983257

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1164G>A; p.A388A; 13:20988616-20988616

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.648C>T; p.F216F; 13:20989132-20989132

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.431C>T; p.P144L; 13:20991316-20991316

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2466C>T; p.S822S; 13:20983240-20983240

 skinmalignant_melanomaSubstitution - coding silent

c.2705T>A; p.I902N; 13:20979758-20979758

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.3257T>C; p.V1086A; 13:20974880-20974880

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2705T>A; p.I902N; 13:20979758-20979758

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.3257T>C; p.V1086A; 13:20974880-20974880

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2206C>T; p.Q736*; 13:20983500-20983500

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.2583G>A; p.A861A; 13:20981548-20981548

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.3115G>A; p.E1039K; 13:20975022-20975022

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.3144C>T; p.D1048D; 13:20974993-20974993

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.3232G>T; p.D1078Y; 13:20974905-20974905

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2475C>T; p.Y825Y; 13:20983231-20983231

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.536C>T; p.S179L; 13:20989244-20989244

 breastcarcinoma; HER-positive_carcinomaSubstitution - Missense

c.536C>T; p.S179L; 13:20989244-20989244

 breastcarcinomaSubstitution - Missense

c.653G>T; p.G218V; 13:20989127-20989127

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1179C>T; p.H393H; 13:20988601-20988601

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1179C>T; p.H393H; 13:20988601-20988601

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.589G>A; p.G197S; 13:20989191-20989191

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.64A>G; p.I22V; 13:21045963-21045963

 livercarcinomaSubstitution - Missense

c.2316C>G; p.I772M; 13:20983390-20983390

 ovaryother; neoplasmSubstitution - Missense

c.64A>G; p.I22V; 13:21045963-21045963

 livercarcinomaSubstitution - Missense

c.3084C>A; p.P1028P; 13:20975053-20975053

 skinmalignant_melanomaSubstitution - coding silent

c.1706A>G; p.D569G; 13:20988074-20988074

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2145C>T; p.A715A; 13:20983561-20983561

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.2688G>A; p.W896*; 13:20979775-20979775

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.1638_1639GG>AA; p.G547S; 13:20988141-20988142

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.991C>A; p.L331M; 13:20988789-20988789

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1846A>G; p.T616A; 13:20987934-20987934

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2712C>T; p.F904F; 13:20979751-20979751

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1920G>T; p.E640D; 13:20983786-20983786

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.3121A>C; p.T1041P; 13:20975016-20975016

 breastcarcinomaSubstitution - Missense

c.2512C>T; p.P838S; 13:20981619-20981619

 skinmalignant_melanomaSubstitution - Missense

c.496C>T; p.P166S; 13:20989284-20989284

 skinmalignant_melanomaSubstitution - Missense

c.2512C>T; p.P838S; 13:20981619-20981619

 skinmalignant_melanomaSubstitution - Missense

c.1174G>A; p.A392T; 13:20988606-20988606

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2964delC; p.Y989fs*17; 13:20975173-20975173

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.238delA; p.I80fs*20; 13:21045789-21045789

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1994A>G; p.K665R; 13:20983712-20983712

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.67C>T; p.R23C; 13:21045960-21045960

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2441C>G; p.T814S; 13:20983265-20983265

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2077C>A; p.L693M; 13:20983629-20983629

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.3155_3156CC>TT; p.P1052L; 13:20974981-20974982

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.3048A>G; p.E1016E; 13:20975089-20975089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.3048A>G; p.E1016E; 13:20975089-20975089

 large_intestine; rectumNSSubstitution - coding silent

c.328G>A; p.A110T; 13:21045699-21045699

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.3200A>C; p.E1067A; 13:20974937-20974937

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.1176_1177delGC; p.H393fs*6; 13:20988603-20988604

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1872G>A; p.R624R; 13:20987908-20987908

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.2659C>T; p.R887C; 13:20981472-20981472

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2044G>T; p.V682L; 13:20983662-20983662

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.2317G>A; p.A773T; 13:20983389-20983389

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2023G>T; p.G675W; 13:20983683-20983683

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1681G>A; p.A561T; 13:20988099-20988099

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1673G>T; p.R558L; 13:20988107-20988107

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1681G>A; p.A561T; 13:20988099-20988099

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.2934C>A; p.F978L; 13:20975203-20975203

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.52C>T; p.R18*; 13:21045975-21045975

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1340T>A; p.V447E; 13:20988440-20988440

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2478G>C; p.Q826H; 13:20983228-20983228

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2552G>A; p.G851E; 13:20981579-20981579

 skinmalignant_melanomaSubstitution - Missense

c.1674C>T; p.R558R; 13:20988106-20988106

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2429T>C; p.F810S; 13:20983277-20983277

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2295G>T; p.E765D; 13:20983411-20983411

 large_intestine; coloncarcinomaSubstitution - Missense

c.1493G>T; p.G498V; 13:20988287-20988287

 central_nervous_system; braingliomaSubstitution - Missense

c.2324T>C; p.L775P; 13:20983382-20983382

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1172G>A; p.R391H; 13:20988608-20988608

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.327C>T; p.N109N; 13:21045700-21045700

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.503C>T; p.T168M; 13:20989277-20989277

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.503C>T; p.T168M; 13:20989277-20989277

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.3122C>T; p.T1041I; 13:20975015-20975015

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.432G>A; p.P144P; 13:20991315-20991315

 pancreascarcinomaSubstitution - coding silent

c.3122C>T; p.T1041I; 13:20975015-20975015

 large_intestine; coloncarcinomaSubstitution - Missense

c.503C>T; p.T168M; 13:20989277-20989277

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2640C>T; p.I880I; 13:20981491-20981491

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.3122C>T; p.T1041I; 13:20975015-20975015

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.119G>A; p.G40E; 13:21045908-21045908

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.119G>A; p.G40E; 13:21045908-21045908

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.2554G>A; p.D852N; 13:20981577-20981577

 breastcarcinomaSubstitution - Missense

c.2003_2006delTTGT; p.F668fs*28; 13:20983700-20983703

 kidneycarcinoma; clear_cell_renal_cell_carcinomaDeletion - Frameshift

c.548A>G; p.Y183C; 13:20989232-20989232

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1489G>A; p.A497T; 13:20988291-20988291

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2073C>T; p.H691H; 13:20983633-20983633

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1927C>G; p.Q643E; 13:20983779-20983779

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1997C>T; p.S666F; 13:20983709-20983709

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1730C>T; p.P577L; 13:20988050-20988050

 skinmalignant_melanomaSubstitution - Missense

c.1557G>A; p.P519P; 13:20988223-20988223

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - coding silent

c.574G>A; p.E192K; 13:20989206-20989206

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.3036C>T; p.N1012N; 13:20975101-20975101

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.3036C>T; p.N1012N; 13:20975101-20975101

 central_nervous_system; braingliomaSubstitution - coding silent

c.1143G>T; p.L381L; 13:20988637-20988637

 thyroidcarcinomaSubstitution - coding silent

c.2113C>T; p.L705L; 13:20983593-20983593

 skinmalignant_melanomaSubstitution - coding silent

c.47G>T; p.R16L; 13:21045980-21045980

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1424C>T; p.P475L; 13:20988356-20988356

 skinmalignant_melanomaSubstitution - Missense

c.1777C>T; p.R593C; 13:20988003-20988003

 central_nervous_system; braingliomaSubstitution - Missense

c.532G>A; p.D178N; 13:20989248-20989248

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.751G>A; p.A251T; 13:20989029-20989029

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2908C>A; p.H970N; 13:20975229-20975229

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1479G>A; p.A493A; 13:20988301-20988301

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1741C>T; p.R581C; 13:20988039-20988039

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.569C>G; p.P190R; 13:20989211-20989211

 breastcarcinomaSubstitution - Missense

c.2888G>A; p.G963E; 13:20975249-20975249

 livercarcinomaSubstitution - Missense

c.2888G>A; p.G963E; 13:20975249-20975249

 livercarcinomaSubstitution - Missense

c.1659C>T; p.G553G; 13:20988121-20988121

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1659C>T; p.G553G; 13:20988121-20988121

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1659C>T; p.G553G; 13:20988121-20988121

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.597C>T; p.D199D; 13:20989183-20989183

 oesophaguscarcinomaSubstitution - coding silent

c.2899C>A; p.L967M; 13:20975238-20975238

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.3046G>A; p.E1016K; 13:20975091-20975091

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1283C>T; p.A428V; 13:20988497-20988497

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.3046G>A; p.E1016K; 13:20975091-20975091

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.3248G>A; p.C1083Y; 13:20974889-20974889

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.531C>A; p.G177G; 13:20989249-20989249

 breastcarcinomaSubstitution - coding silent

c.2725G>A; p.G909R; 13:20979738-20979738

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.2398G>T; p.D800Y; 13:20983308-20983308

 breastcarcinomaSubstitution - Missense

c.359C>G; p.A120G; 13:20991388-20991388

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.2987C>T; p.P996L; 13:20975150-20975150

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1759G>A; p.E587K; 13:20988021-20988021

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2679C>A; p.L893L; 13:20979784-20979784

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.314A>C; p.Q105P; 13:21045713-21045713

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.3161G>A; p.R1054Q; 13:20974976-20974976

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2964C>A; p.P988P; 13:20975173-20975173

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.628C>T; p.P210S; 13:20989152-20989152

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2775G>A; p.V925V; 13:20975362-20975362

 lungcarcinoma; non_small_cell_carcinomaSubstitution - coding silent

c.2775G>A; p.V925V; 13:20975362-20975362

 lungcarcinoma; non_small_cell_carcinomaSubstitution - coding silent

c.1583C>T; p.S528L; 13:20988197-20988197

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2114T>C; p.L705P; 13:20983592-20983592

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.3128G>T; p.R1043L; 13:20975009-20975009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 breastcarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 thyroidother; neoplasmSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.971C>T; p.A324V; 13:20988809-20988809

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2030G>T; p.G677V; 13:20983676-20983676

 bone; fibulaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.2858G>T; p.C953F; 13:20975279-20975279

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2018C>T; p.T673I; 13:20983688-20983688

 skinmalignant_melanomaSubstitution - Missense

c.2176G>A; p.E726K; 13:20983530-20983530

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2922C>T; p.S974S; 13:20975215-20975215

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.215C>T; p.P72L; 13:21045812-21045812

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1033C>T; p.Q345*; 13:20988747-20988747

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1788C>G; p.S596R; 13:20987992-20987992

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2305C>T; p.R769W; 13:20983401-20983401

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2305C>T; p.R769W; 13:20983401-20983401

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2305C>T; p.R769W; 13:20983401-20983401

 large_intestine; coloncarcinomaSubstitution - Missense

c.2305C>T; p.R769W; 13:20983401-20983401

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2645C>T; p.P882L; 13:20981486-20981486

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1771G>T; p.E591*; 13:20988009-20988009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1771G>T; p.E591*; 13:20988009-20988009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1771G>T; p.E591*; 13:20988009-20988009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1771G>T; p.E591*; 13:20988009-20988009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1771G>T; p.E591*; 13:20988009-20988009

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1243C>T; p.R415W; 13:20988537-20988537

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2582C>T; p.A861V; 13:20981549-20981549

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1861G>C; p.V621L; 13:20987919-20987919

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.387C>T; p.I129I; 13:20991360-20991360

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.2568C>T; p.T856T; 13:20981563-20981563

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1696G>T; p.G566C; 13:20988084-20988084

 prostatecarcinomaSubstitution - Missense

c.3127C>T; p.R1043*; 13:20975010-20975010

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.2967C>T; p.Y989Y; 13:20975170-20975170

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.602_603CC>TT; p.P201L; 13:20989177-20989178

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.81A>G; p.K27K; 13:21045946-21045946

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2063T>G; p.V688G; 13:20983643-20983643

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2186T>A; p.V729D; 13:20983520-20983520

 central_nervous_system; braingliomaSubstitution - Missense

c.2174A>G; p.N725S; 13:20983532-20983532

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.3011C>T; p.P1004L; 13:20975126-20975126

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2587A>G; p.K863E; 13:20981544-20981544

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.2857T>G; p.C953G; 13:20975280-20975280

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.120A>G; p.G40G; 13:21045907-21045907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.120A>G; p.G40G; 13:21045907-21045907

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.926C>T; p.A309V; 13:20988854-20988854

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2713G>A; p.E905K; 13:20979750-20979750

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1611C>T; p.C537C; 13:20988169-20988169

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.2859C>A; p.C953*; 13:20975278-20975278

 ovarycarcinoma; mucinous_carcinomaSubstitution - Nonsense

c.2859C>A; p.C953*; 13:20975278-20975278

 ovarycarcinoma; mucinous_carcinomaSubstitution - Nonsense

c.284C>T; p.A95V; 13:21045743-21045743

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1547C>T; p.P516L; 13:20988233-20988233

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1547C>T; p.P516L; 13:20988233-20988233

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.424C>A; p.L142M; 13:20991323-20991323

 haematopoietic_and_lymphoid_tissue; small_intestinelymphoid_neoplasm; enteropathy_type_T_cell_lymphomaSubstitution - Missense

c.2126A>G; p.Q709R; 13:20983580-20983580

 kidneyother; neoplasmSubstitution - Missense

c.1650G>T; p.E550D; 13:20988130-20988130

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.47G>A; p.R16Q; 13:21045980-21045980

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2494A>G; p.R832G; 13:20981637-20981637

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

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