Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3579

Name

CXCR2

Synonymous

chemokine (C-X-C motif) receptor 2;CXCR2;chemokine (C-X-C motif) receptor 2

Definition

C-X-C chemokine receptor type 2|CXC-R2|CXCR-2|CXCR2 gene for IL8 receptor type B|GRO/MGSA receptor|IL-8 receptor type 2|IL-8R B|chemokine (CXC) receptor 2|high affinity interleukin-8 receptor B|interleukin 8 receptor B|interleukin 8 receptor type 2|interl

Position

2q35

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.02.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.651C>T; p.S217S; 2:218135452-218135452

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.651C>T; p.S217S; 2:218135452-218135452

 skinmalignant_melanomaSubstitution - coding silent

c.993A>G; p.I331M; 2:218135794-218135794

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.865C>T; p.R289C; 2:218135666-218135666

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.721G>T; p.A241S; 2:218135522-218135522

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.279C>A; p.A93A; 2:218135080-218135080

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.234C>T; p.V78V; 2:218135035-218135035

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.876C>T; p.I292I; 2:218135677-218135677

 skinmalignant_melanomaSubstitution - coding silent

c.689G>A; p.C230Y; 2:218135490-218135490

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.900G>A; p.E300E; 2:218135701-218135701

 skinmalignant_melanomaSubstitution - coding silent

c.316G>A; p.A106T; 2:218135117-218135117

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.316G>A; p.A106T; 2:218135117-218135117

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.316G>A; p.A106T; 2:218135117-218135117

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.843G>A; p.V281V; 2:218135644-218135644

 skinmalignant_melanomaSubstitution - coding silent

c.875_876TC>CT; p.I292T; 2:218135676-218135677

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.537T>A; p.P179P; 2:218135338-218135338

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.506T>G; p.I169S; 2:218135307-218135307

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.293C>T; p.A98V; 2:218135094-218135094

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.787T>C; p.C263R; 2:218135588-218135588

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.862C>A; p.R288S; 2:218135663-218135663

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.710C>T; p.T237M; 2:218135511-218135511

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.883G>C; p.A295P; 2:218135684-218135684

 central_nervous_system; braingliomaSubstitution - Missense

c.584C>A; p.A195D; 2:218135385-218135385

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.378G>A; p.K126K; 2:218135179-218135179

 skinmalignant_melanomaSubstitution - coding silent

c.492C>A; p.F164L; 2:218135293-218135293

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.567A>G; p.S189S; 2:218135368-218135368

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.678C>T; p.I226I; 2:218135479-218135479

 skinmalignant_melanomaSubstitution - coding silent

c.239G>A; p.R80H; 2:218135040-218135040

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.239G>A; p.R80H; 2:218135040-218135040

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.239G>A; p.R80H; 2:218135040-218135040

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.239G>A; p.R80H; 2:218135040-218135040

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.113C>T; p.P38L; 2:218134914-218134914

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.113C>T; p.P38L; 2:218134914-218134914

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.279C>T; p.A93A; 2:218135080-218135080

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.578G>T; p.S193I; 2:218135379-218135379

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.559G>A; p.V187I; 2:218135360-218135360

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.559G>A; p.V187I; 2:218135360-218135360

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.390C>A; p.F130L; 2:218135191-218135191

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.328A>G; p.N110D; 2:218135129-218135129

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.786C>T; p.L262L; 2:218135587-218135587

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.786C>T; p.L262L; 2:218135587-218135587

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.786C>T; p.L262L; 2:218135587-218135587

 thyroidother; neoplasmSubstitution - coding silent

c.4G>A; p.E2K; 2:218134805-218134805

 skinmalignant_melanomaSubstitution - Missense

c.920G>T; p.S307I; 2:218135721-218135721

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.933C>T; p.P311P; 2:218135734-218135734

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.933C>T; p.P311P; 2:218135734-218135734

 breastcarcinomaSubstitution - coding silent

c.147T>C; p.Y49Y; 2:218134948-218134948

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.668C>A; p.P223Q; 2:218135469-218135469

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.204C>T; p.L68L; 2:218135005-218135005

 skin; head_neckmalignant_melanoma; superficial_spreadingSubstitution - coding silent

c.109G>A; p.A37T; 2:218134910-218134910

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.204C>T; p.L68L; 2:218135005-218135005

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.109G>A; p.A37T; 2:218134910-218134910

 central_nervous_system; braingliomaSubstitution - Missense

c.18G>A; p.M6I; 2:218134819-218134819

 skinmalignant_melanomaSubstitution - Missense

c.18G>A; p.M6I; 2:218134819-218134819

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.280G>A; p.D94N; 2:218135081-218135081

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.694G>A; p.G232R; 2:218135495-218135495

 central_nervous_system; braingliomaSubstitution - Missense

c.971G>A; p.G324E; 2:218135772-218135772

 skinmalignant_melanomaSubstitution - Missense

c.108C>T; p.A36A; 2:218134909-218134909

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.49G>A; p.G17S; 2:218134850-218134850

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.70A>G; p.S24G; 2:218134871-218134871

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.975C>T; p.L325L; 2:218135776-218135776

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.959A>C; p.K320T; 2:218135760-218135760

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.964C>T; p.R322C; 2:218135765-218135765

 skinmalignant_melanomaSubstitution - Missense

c.981G>T; p.K327N; 2:218135782-218135782

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.610A>G; p.T204A; 2:218135411-218135411

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.610A>G; p.T204A; 2:218135411-218135411

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.624G>A; p.R208R; 2:218135425-218135425

 skinmalignant_melanomaSubstitution - coding silent

c.744G>A; p.R248R; 2:218135545-218135545

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.862C>T; p.R288C; 2:218135663-218135663

 pancreascarcinomaSubstitution - Missense

c.862C>T; p.R288C; 2:218135663-218135663

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.661_662insT; p.V222fs*19; 2:218135462-218135463

 livercarcinomaInsertion - Frameshift

c.707G>A; p.R236H; 2:218135508-218135508

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.451G>A; p.A151T; 2:218135252-218135252

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.707G>A; p.R236H; 2:218135508-218135508

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.898G>A; p.E300K; 2:218135699-218135699

 skinmalignant_melanomaSubstitution - Missense

c.333C>A; p.G111G; 2:218135134-218135134

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.193G>A; p.G65R; 2:218134994-218134994

 skinmalignant_melanomaSubstitution - Missense

c.235G>A; p.G79S; 2:218135036-218135036

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.236G>A; p.G79D; 2:218135037-218135037

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.570C>G; p.S190S; 2:218135371-218135371

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.486C>T; p.V162V; 2:218135287-218135287

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.346A>G; p.T116A; 2:218135147-218135147

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.57T>A; p.D19E; 2:218134858-218134858

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.315C>T; p.A105A; 2:218135116-218135116

 breastcarcinoma; ER-PR-positive_carcinomaSubstitution - coding silent

c.17T>C; p.M6T; 2:218134818-218134818

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.118G>A; p.E40K; 2:218134919-218134919

 skinmalignant_melanomaSubstitution - Missense

c.573T>C; p.N191N; 2:218135374-218135374

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.884C>T; p.A295V; 2:218135685-218135685

 skinmalignant_melanomaSubstitution - Missense

c.884C>T; p.A295V; 2:218135685-218135685

 skinmalignant_melanomaSubstitution - Missense

c.335G>A; p.W112*; 2:218135136-218135136

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Nonsense

c.313G>C; p.A105P; 2:218135114-218135114

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1040C>T; p.S347F; 2:218135841-218135841

 skinmalignant_melanomaSubstitution - Missense

c.58C>A; p.L20I; 2:218134859-218134859

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.248C>T; p.T83I; 2:218135049-218135049

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1060G>T; p.G354W; 2:218135861-218135861

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.489A>C; p.K163N; 2:218135290-218135290

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.518C>T; p.S173F; 2:218135319-218135319

 skinmalignant_melanomaSubstitution - Missense

c.201C>T; p.S67S; 2:218135002-218135002

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.931C>T; p.P311S; 2:218135732-218135732

 skinmalignant_melanomaSubstitution - Missense

c.303G>C; p.L101F; 2:218135104-218135104

 pancreascarcinomaSubstitution - Missense

c.303G>C; p.L101F; 2:218135104-218135104

 pancreascarcinomaSubstitution - Missense

c.303G>C; p.L101F; 2:218135104-218135104

 pancreascarcinomaSubstitution - Missense

c.303G>C; p.L101F; 2:218135104-218135104

 pancreascarcinomaSubstitution - Missense

c.431G>A; p.R144H; 2:218135232-218135232

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1016C>T; p.S339F; 2:218135817-218135817

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.916C>T; p.H306Y; 2:218135717-218135717

 skinmalignant_melanomaSubstitution - Missense

c.850G>A; p.E284K; 2:218135651-218135651

 NSmalignant_melanomaSubstitution - Missense

c.985C>A; p.L329I; 2:218135786-218135786

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.850G>A; p.E284K; 2:218135651-218135651

 NSmalignant_melanomaSubstitution - Missense

c.128C>T; p.S43F; 2:218134929-218134929

 skinmalignant_melanomaSubstitution - Missense

c.622C>T; p.R208W; 2:218135423-218135423

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.622C>T; p.R208W; 2:218135423-218135423

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.422G>A; p.S141N; 2:218135223-218135223

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1063C>A; p.H355N; 2:218135864-218135864

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.106G>A; p.A36T; 2:218134907-218134907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.78C>A; p.S26R; 2:218134879-218134879

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.457C>T; p.R153C; 2:218135258-218135258

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.764C>T; p.A255V; 2:218135565-218135565

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.764C>T; p.A255V; 2:218135565-218135565

 skinmalignant_melanomaSubstitution - Missense

c.27C>T; p.D9D; 2:218134828-218134828

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.754G>T; p.V252F; 2:218135555-218135555

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.319T>A; p.S107T; 2:218135120-218135120

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.856T>C; p.C286R; 2:218135657-218135657

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.137T>C; p.I46T; 2:218134938-218134938

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

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