Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4303

Name

FOXO4

Synonymous

forkhead box O4;FOXO4;forkhead box O4

Definition

fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

Position

Xq13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

Top

There is no record for FOXO4

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.357G>T; p.E119D; 23:71096885-71096885

 breastcarcinomaSubstitution - Missense

c.275G>A; p.R92Q; 23:71096803-71096803

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1006G>A; p.G336S; 23:71101236-71101236

 oesophaguscarcinomaSubstitution - Missense

c.167delA; p.K57fs*32; 23:71096695-71096695

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.233G>A; p.G78E; 23:71096761-71096761

 skinmalignant_melanomaSubstitution - Missense

c.483C>T; p.H161H; 23:71100713-71100713

 lungcarcinoid-endocrine_tumour; typicalSubstitution - coding silent

c.846G>T; p.A282A; 23:71101076-71101076

 livercarcinomaSubstitution - coding silent

c.1030T>C; p.S344P; 23:71101260-71101260

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.292C>T; p.R98W; 23:71096820-71096820

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.515C>T; p.T172I; 23:71100745-71100745

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.247G>A; p.G83R; 23:71096775-71096775

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.187C>T; p.R63C; 23:71096715-71096715

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.260C>T; p.A87V; 23:71096788-71096788

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.40G>A; p.A14T; 23:71096568-71096568

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1471A>G; p.M491V; 23:71101701-71101701

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.576_577CC>TA; p.R193S; 23:71100806-71100807

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1405G>T; p.D469Y; 23:71101635-71101635

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.336G>T; p.Q112H; 23:71096864-71096864

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.934C>G; p.L312V; 23:71101164-71101164

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1308A>C; p.P436P; 23:71101538-71101538

 pancreascarcinoid-endocrine_tumourSubstitution - coding silent

c.1093G>A; p.A365T; 23:71101323-71101323

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1141G>A; p.V381I; 23:71101371-71101371

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1141G>A; p.V381I; 23:71101371-71101371

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1141G>A; p.V381I; 23:71101371-71101371

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1141G>A; p.V381I; 23:71101371-71101371

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1181C>T; p.P394L; 23:71101411-71101411

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1094C>A; p.A365D; 23:71101324-71101324

 bone; tibiaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.808C>A; p.R270R; 23:71101038-71101038

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.305G>A; p.G102E; 23:71096833-71096833

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1144C>T; p.L382F; 23:71101374-71101374

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.739C>T; p.R247C; 23:71100969-71100969

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1162_1163CC>AA; p.P388N; 23:71101392-71101393

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1230G>T; p.T410T; 23:71101460-71101460

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.972C>A; p.L324L; 23:71101202-71101202

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.748G>A; p.A250T; 23:71100978-71100978

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.650C>T; p.S217F; 23:71100880-71100880

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.132G>A; p.P44P; 23:71096660-71096660

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1230G>A; p.T410T; 23:71101460-71101460

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1337C>T; p.P446L; 23:71101567-71101567

 skinmalignant_melanomaSubstitution - Missense

c.670G>A; p.E224K; 23:71100900-71100900

 breastcarcinomaSubstitution - Missense

c.1359G>T; p.V453V; 23:71101589-71101589

 pancreascarcinomaSubstitution - coding silent

c.179C>T; p.T60M; 23:71096707-71096707

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.770G>A; p.R257H; 23:71101000-71101000

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.908G>T; p.G303V; 23:71101138-71101138

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.698G>A; p.G233D; 23:71100928-71100928

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.952C>T; p.L318L; 23:71101182-71101182

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.290G>A; p.R97H; 23:71096818-71096818

 pancreascarcinomaSubstitution - Missense

c.287C>T; p.S96F; 23:71096815-71096815

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.562_566delGGCAA; p.G188fs*11; 23:71100792-71100796

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.426T>A; p.G142G; 23:71096954-71096954

 breastcarcinomaSubstitution - coding silent

c.623G>A; p.R208H; 23:71100853-71100853

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1288A>C; p.T430P; 23:71101518-71101518

 breastcarcinomaSubstitution - Missense

c.1072G>T; p.G358W; 23:71101302-71101302

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.96C>T; p.T32T; 23:71096624-71096624

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.246C>T; p.P82P; 23:71096774-71096774

 breastcarcinomaSubstitution - coding silent

c.1149G>T; p.M383I; 23:71101379-71101379

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.527C>G; p.S176C; 23:71100757-71100757

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.655C>A; p.L219M; 23:71100885-71100885

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.775C>T; p.R259*; 23:71101005-71101005

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.301T>A; p.W101R; 23:71096829-71096829

 livercarcinomaSubstitution - Missense

c.301T>A; p.W101R; 23:71096829-71096829

 livercarcinomaSubstitution - Missense

c.810G>A; p.R270R; 23:71101040-71101040

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1343C>A; p.A448D; 23:71101573-71101573

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.673G>A; p.G225S; 23:71100903-71100903

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1041C>A; p.S347R; 23:71101271-71101271

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.961C>T; p.R321W; 23:71101191-71101191

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.961C>T; p.R321W; 23:71101191-71101191

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.846G>A; p.A282A; 23:71101076-71101076

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.606C>A; p.S202R; 23:71100836-71100836

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1092G>A; p.Q364Q; 23:71101322-71101322

 ovaryother; neoplasmSubstitution - coding silent

c.1299G>A; p.M433I; 23:71101529-71101529

 breastcarcinomaSubstitution - Missense

c.639G>A; p.K213K; 23:71100869-71100869

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.398G>A; p.R133H; 23:71096926-71096926

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.575G>A; p.R192H; 23:71100805-71100805

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1195C>T; p.L399L; 23:71101425-71101425

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.569C>G; p.A190G; 23:71100799-71100799

 livercarcinomaSubstitution - Missense

c.569C>G; p.A190G; 23:71100799-71100799

 livercarcinomaSubstitution - Missense

c.272C>A; p.P91H; 23:71096800-71096800

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.765C>A; p.T255T; 23:71100995-71100995

 pancreascarcinomaSubstitution - coding silent

c.1236C>A; p.V412V; 23:71101466-71101466

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.298G>T; p.A100S; 23:71096826-71096826

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.745G>A; p.E249K; 23:71100975-71100975

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.595G>A; p.D199N; 23:71100825-71100825

 livercarcinomaSubstitution - Missense

c.1122G>A; p.T374T; 23:71101352-71101352

 prostatecarcinomaSubstitution - coding silent

c.1110C>T; p.L370L; 23:71101340-71101340

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1129C>T; p.P377S; 23:71101359-71101359

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.327C>T; p.L109L; 23:71096855-71096855

 breastcarcinomaSubstitution - coding silent

c.7C>G; p.P3A; 23:71096535-71096535

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1196_1197insG; p.L402fs*6; 23:71101426-71101427

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1196_1197insG; p.L402fs*6; 23:71101426-71101427

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1233C>T; p.G411G; 23:71101463-71101463

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1211C>T; p.S404F; 23:71101441-71101441

 skinmalignant_melanomaSubstitution - Missense

c.347G>A; p.S116N; 23:71096875-71096875

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.966T>G; p.S322R; 23:71101196-71101196

 breastcarcinomaSubstitution - Missense

c.674G>A; p.G225D; 23:71100904-71100904

 kidneyother; neoplasmSubstitution - Missense

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