Entrez Gene

Basic Information
Gene ID	4303
Name	FOXO4
Synonymous	AFX\|AFX1\|MLLT7;forkhead box O4;FOXO4;forkhead box O4
Definition	fork head domain transcription factor AFX1\|forkhead box protein O4\|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Position	Xq13.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
foxo4(h) + ATP --AKT-1(h)--> foxo4(h){pT28}{pS193}{pS258} + ADP (phosphorylation)
foxo4(h) + ATP --AKT-1(r)--> foxo4(h){pT28}{pS193}{pS258} + ADP (phosphorylation)
Ran(h):GTP + CRM1(h) + foxo4(h) <==> CRM1(h):foxo4(h):Ran(h):GTP (binding; translocation)
foxo4(h) + ATP --> foxo4(h){pT447}{pT451} + ADP (phosphorylation)
foxo4(h) --> CAV1(h) (transactivation)
foxo4(h) + acetyl-CoA --CBP(h)--> foxo4(h){ace} + CoA (acetylation)
smad4(h) + foxo4(h) <==> smad4(h):foxo4(h) (binding)
foxo4(h) + Smad3(m.s.) <==> foxo4(h):Smad3(m.s.) (binding)
Smad4(m.s.) + foxo4(h) <==> Smad4(m.s.):foxo4(h) (binding)
Pin1(h) + foxo4(h) <==> Pin1(h):foxo4(h) (binding)
foxo4(h) --> foxo4(h) (expression).
foxo4(h){ace} --SIRT1(h)--> foxo4(h) + acetyl (deacetylation)
foxo4(h) --> IGFBP1(h) (DNA binding; transactivation)
foxo4(h) --> RBL2(h) (DNA binding; transactivation).
foxo4(h) --> BCL6(h) (DNA binding; transactivation).
foxo4(h) --> foxo4(h) (expression).
FOXO4(h) --> foxo4b(h) (expression).
FOXO4(h) --> foxo4a(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
32	Phosphothreonine (by PKB/AKT1).		Swiss-Prot 53.0
197	Phosphoserine (by PKB/AKT1).		Swiss-Prot 53.0
262	Phosphoserine (by PKB/AKT1).		Swiss-Prot 53.0
455	Phosphothreonine (MAPK8;MAPK9)	15538382	Phospho.ELM 6.0
32	Phosphothreonine	15538382;11896584	Phospho.ELM 6.0
451	Phosphothreonine (MAPK8;MAPK9;)	11689711;15538382	Phospho.ELM 6.0