Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4494

Name

MT1F

Synonymous

metallothionein 1F;MT1F;metallothionein 1F

Definition

MT-1F|MT-IF|metallothionein 1F (functional)|metallothionein-1F|metallothionein-IF

Position

16q13

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.185G>A; p.*62*; 16:56659163-56659163

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.114C>T; p.P38P; 16:56659092-56659092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.56G>A; p.C19Y; 16:56658702-56658702

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.154G>A; p.G52R; 16:56659132-56659132

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.65A>C; p.K22T; 16:56658711-56658711

 skinmalignant_melanomaSubstitution - Missense

c.156G>A; p.G52G; 16:56659134-56659134

 skinmalignant_melanomaSubstitution - coding silent

c.158C>T; p.A53V; 16:56659136-56659136

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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