Entrez Gene

Basic Information
Gene ID	4916
Name	NTRK3
Synonymous	neurotrophic tyrosine kinase, receptor, type 3;NTRK3;neurotrophic tyrosine kinase, receptor, type 3
Definition	ETS related protein-neurotrophic receptor tyrosine kinase fusion protein\|ETV6-NTRK3 fusion\|NT-3 growth factor receptor\|tyrosine kinase receptor C
Position	15q25
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.04.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2083A>T; p.I695F; 15:87929241-87929241	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2468T>C; p.I823T; 15:87876945-87876945	large_intestine; colon	carcinoma	Substitution - Missense
c.2197T>G; p.F733V; 15:87880365-87880365	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2468T>C; p.I823T; 15:87876945-87876945	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1223T>A; p.I408N; 15:88128716-88128716	kidney	other; neoplasm	Substitution - Missense
c.704G>A; p.G235E; 15:88136528-88136528	skin	malignant_melanoma	Substitution - Missense
c.1842C>A; p.I614I; 15:87933059-87933059	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1839C>T; p.L613L; 15:87933062-87933062	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2089G>A; p.D697N; 15:87929235-87929235	skin	malignant_melanoma	Substitution - Missense
c.1805A>G; p.K602R; 15:87933096-87933096	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.447G>A; p.T149T; 15:88147352-88147352	pancreas	carcinoma	Substitution - coding silent
c.1752T>A; p.D584E; 15:87933149-87933149	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2338G>C; p.V780L; 15:87877075-87877075	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1007T>C; p.L336P; 15:88135298-88135298	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.543G>T; p.K181N; 15:88137483-88137483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1007T>C; p.L336P; 15:88135298-88135298	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>C; p.D240H; 15:88136514-88136514	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1007T>C; p.L336P; 15:88135298-88135298	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2446G>T; p.A816S; 15:87876967-87876967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.995C>T; p.T332M; 15:88135310-88135310	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.995C>T; p.T332M; 15:88135310-88135310	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1503G>C; p.V501V; 15:88032939-88032939	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1837delC; p.L613fs*8; 15:87933064-87933064	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.224A>G; p.D75G; 15:88255930-88255930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.864C>T; p.N288N; 15:88135942-88135942	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.864C>T; p.N288N; 15:88135942-88135942	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.447G>T; p.T149T; 15:88147352-88147352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2175T>C; p.P725P; 15:87880387-87880387	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.337T>A; p.S113T; 15:88183476-88183476	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1578G>A; p.P526P; 15:88032864-88032864	prostate	carcinoma	Substitution - coding silent
c.648C>T; p.H216H; 15:88136584-88136584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1618C>A; p.L540M; 15:87940721-87940721	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1211C>T; p.T404M; 15:88128728-88128728	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.942G>T; p.E314D; 15:88135363-88135363	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.56G>A; p.G19E; 15:88256098-88256098	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606G>T; p.M202I; 15:88137420-88137420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2083A>G; p.I695V; 15:87929241-87929241	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2162G>A; p.R721H; 15:87880400-87880400	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.976C>G; p.R326G; 15:88135329-88135329	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1842C>T; p.I614I; 15:87933059-87933059	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2162G>A; p.R721H; 15:87880400-87880400	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2318G>A; p.R773H; 15:87877095-87877095	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.845T>G; p.L282R; 15:88135961-88135961	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.808C>G; p.L270V; 15:88135998-88135998	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2227G>A; p.G743R; 15:87880335-87880335	skin	malignant_melanoma	Substitution - Missense
c.2386G>A; p.E796K; 15:87877027-87877027	skin	malignant_melanoma	Substitution - Missense
c.2386G>A; p.E796K; 15:87877027-87877027	skin	malignant_melanoma	Substitution - Missense
c.2386G>A; p.E796K; 15:87877027-87877027	skin	malignant_melanoma	Substitution - Missense
c.61G>T; p.V21F; 15:88256093-88256093	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.755A>C; p.N252T; 15:88136477-88136477	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1463T>C; p.I488T; 15:88032979-88032979	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2226C>T; p.F742F; 15:87880336-87880336	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1725_1726GG>AA; p.D576N; 15:87933175-87933176	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2226C>T; p.F742F; 15:87880336-87880336	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1463T>C; p.I488T; 15:88032979-88032979	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1889+1G>T; p.?; 15:87933011-87933011	lung	carcinoma; adenocarcinoma	Unknown
c.280C>A; p.L94I; 15:88184268-88184268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1532T>C; p.I511T; 15:88032910-88032910	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.516G>T; p.Q172H; 15:88137510-88137510	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1185_1186CC>TT; p.L396F; 15:88135119-88135120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1401C>T; p.P467P; 15:88033041-88033041	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1430C>G; p.S477*; 15:88033012-88033012	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.446C>T; p.T149M; 15:88147353-88147353	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1604G>T; p.R535M; 15:87940735-87940735	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.604A>T; p.M202L; 15:88137422-88137422	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2192G>A; p.R731Q; 15:87880370-87880370	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2192G>A; p.R731Q; 15:87880370-87880370	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2278C>A; p.L760I; 15:87880284-87880284	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.830A>G; p.D277G; 15:88135976-88135976	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.824G>A; p.S275N; 15:88135982-88135982	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.429G>T; p.S143S; 15:88147370-88147370	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1182C>A; p.H394Q; 15:88135123-88135123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1748A>C; p.K583T; 15:87933153-87933153	skin	malignant_melanoma	Substitution - Missense
c.1726G>A; p.D576N; 15:87933175-87933175	skin	malignant_melanoma	Substitution - Missense
c.1726G>A; p.D576N; 15:87933175-87933175	skin; extremity	malignant_melanoma	Substitution - Missense
c.1726G>A; p.D576N; 15:87933175-87933175	skin	malignant_melanoma	Substitution - Missense
c.472G>A; p.E158K; 15:88137554-88137554	skin	malignant_melanoma	Substitution - Missense
c.1234G>A; p.E412K; 15:88127221-88127221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2120C>T; p.T707M; 15:87929204-87929204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2001G>A; p.M667I; 15:87929323-87929323	skin	malignant_melanoma	Substitution - Missense
c.139C>T; p.R47W; 15:88256015-88256015	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1686G>T; p.P562P; 15:87940653-87940653	skin	malignant_melanoma	Substitution - coding silent
c.1792G>T; p.E598*; 15:87933109-87933109	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.695A>G; p.N232S; 15:88136537-88136537	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.695A>G; p.N232S; 15:88136537-88136537	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1749G>A; p.K583K; 15:87933152-87933152	skin	malignant_melanoma	Substitution - coding silent
c.2029C>T; p.H677Y; 15:87929295-87929295	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1749G>A; p.K583K; 15:87933152-87933152	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2029C>T; p.H677Y; 15:87929295-87929295	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2029C>T; p.H677Y; 15:87929295-87929295	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.632A>T; p.E211V; 15:88136600-88136600	stomach	carcinoma	Substitution - Missense
c.2029C>T; p.H677Y; 15:87929295-87929295	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2161_2162CG>TT; p.R721F; 15:87880400-87880401	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.2161_2162CG>TT; p.R721F; 15:87880400-87880401	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.1392G>A; p.M464I; 15:88126275-88126275	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1590G>A; p.V530V; 15:87940749-87940749	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2260A>G; p.K754E; 15:87880302-87880302	skin	malignant_melanoma	Substitution - Missense
c.2079G>A; p.V693V; 15:87929245-87929245	skin	malignant_melanoma	Substitution - coding silent
c.1629A>C; p.E543D; 15:87940710-87940710	stomach	carcinoma; tubular_adenocarcinoma	Substitution - Missense
c.1488C>T; p.A496A; 15:88032954-88032954	breast	carcinoma	Substitution - coding silent
c.2388A>G; p.E796E; 15:87877025-87877025	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.625C>A; p.L209I; 15:88136607-88136607	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2173C>G; p.P725A; 15:87880389-87880389	liver	carcinoma	Substitution - Missense
c.2173C>G; p.P725A; 15:87880389-87880389	liver	carcinoma	Substitution - Missense
c.844C>A; p.L282M; 15:88135962-88135962	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1643C>T; p.A548V; 15:87940696-87940696	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1488C>G; p.A496A; 15:88032954-88032954	thyroid	other; neoplasm	Substitution - coding silent
c.808C>A; p.L270M; 15:88135998-88135998	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1350C>T; p.F450F; 15:88126317-88126317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1350C>T; p.F450F; 15:88126317-88126317	skin	malignant_melanoma	Substitution - coding silent
c.1350C>T; p.F450F; 15:88126317-88126317	skin	malignant_melanoma	Substitution - coding silent
c.1350C>T; p.F450F; 15:88126317-88126317	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1350C>T; p.F450F; 15:88126317-88126317	skin	malignant_melanoma	Substitution - coding silent
c.1372C>T; p.R458*; 15:88126295-88126295	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2304C>A; p.C768*; 15:87877109-87877109	liver	carcinoma	Substitution - Nonsense
c.2275C>A; p.Q759K; 15:87880287-87880287	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1293+3G>A; p.?; 15:88127159-88127159	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.359C>A; p.P120H; 15:88183454-88183454	liver	carcinoma	Substitution - Missense
c.664C>T; p.R222*; 15:88136568-88136568	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.359C>A; p.P120H; 15:88183454-88183454	liver	carcinoma	Substitution - Missense
c.2258G>A; p.G753E; 15:87880304-87880304	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.359C>A; p.P120H; 15:88183454-88183454	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.926G>T; p.S309I; 15:88135379-88135379	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.108T>G; p.C36W; 15:88256046-88256046	liver	carcinoma	Substitution - Missense
c.1076C>T; p.S359F; 15:88135229-88135229	skin	malignant_melanoma	Substitution - Missense
c.163C>T; p.P55S; 15:88255991-88255991	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1067G>A; p.G356E; 15:88135238-88135238	skin	malignant_melanoma	Substitution - Missense
c.2161C>T; p.R721C; 15:87880401-87880401	skin	malignant_melanoma	Substitution - Missense
c.1003T>C; p.W335R; 15:88135302-88135302	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2161C>T; p.R721C; 15:87880401-87880401	skin	malignant_melanoma	Substitution - Missense
c.536A>G; p.E179G; 15:88137490-88137490	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1201C>T; p.P401S; 15:88135104-88135104	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1213G>A; p.D405N; 15:88128726-88128726	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1822G>T; p.G608C; 15:87933079-87933079	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1375C>G; p.R459G; 15:88126292-88126292	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1205-1G>T; p.?; 15:88128735-88128735	stomach	carcinoma	Unknown
c.1963delC; p.Q655fs*38; 15:87929361-87929361	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1989C>T; p.I663I; 15:87929335-87929335	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2317C>T; p.R773C; 15:87877096-87877096	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2032C>T; p.R678*; 15:87929292-87929292	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.959G>T; p.C320F; 15:88135346-88135346	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1150C>A; p.L384M; 15:88135155-88135155	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.R306H; 15:88135388-88135388	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2037C>T; p.D679D; 15:87929287-87929287	liver	carcinoma	Substitution - coding silent
c.687C>T; p.I229I; 15:88136545-88136545	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.917G>A; p.R306H; 15:88135388-88135388	pancreas	carcinoma	Substitution - Missense
c.1834C>G; p.P612A; 15:87933067-87933067	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2439G>T; p.L813F; 15:87876974-87876974	breast	carcinoma	Substitution - Missense
c.693C>A; p.C231*; 15:88136539-88136539	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.2439G>T; p.L813F; 15:87876974-87876974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2084T>C; p.I695T; 15:87929240-87929240	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2439G>T; p.L813F; 15:87876974-87876974	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1444C>T; p.H482Y; 15:88032998-88032998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2041G>A; p.A681T; 15:87929283-87929283	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.729G>C; p.W243C; 15:88136503-88136503	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1008G>T; p.L336L; 15:88135297-88135297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1552C>T; p.R518C; 15:88032890-88032890	liver	carcinoma	Substitution - Missense
c.1768G>A; p.E590K; 15:87933133-87933133	skin	malignant_melanoma	Substitution - Missense
c.1028G>C; p.R343P; 15:88135277-88135277	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.184delT; p.S62fs*24; 15:88255970-88255970	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1485T>G; p.D495E; 15:88032957-88032957	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.110T>C; p.V37A; 15:88256044-88256044	skin	malignant_melanoma	Substitution - Missense
c.2329C>T; p.R777W; 15:87877084-87877084	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2335C>A; p.R779R; 15:87877078-87877078	skin	malignant_melanoma	Substitution - coding silent
c.2059G>A; p.V687I; 15:87929265-87929265	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2059G>A; p.V687I; 15:87929265-87929265	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.743T>C; p.L248P; 15:88136489-88136489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.V307V; 15:88135384-88135384	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.743T>C; p.L248P; 15:88136489-88136489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2401T>C; p.L801L; 15:87877012-87877012	skin	malignant_melanoma	Substitution - coding silent
c.1614C>T; p.I538I; 15:87940725-87940725	skin	malignant_melanoma	Substitution - coding silent
c.1614C>T; p.I538I; 15:87940725-87940725	skin	malignant_melanoma	Substitution - coding silent
c.743T>C; p.L248P; 15:88136489-88136489	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>A; p.P415H; 15:88127211-88127211	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.947G>A; p.R316H; 15:88135358-88135358	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1744C>T; p.R582W; 15:87933157-87933157	breast	carcinoma	Substitution - Missense
c.1035C>A; p.S345S; 15:88135270-88135270	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.323+1G>T; p.?; 15:88184224-88184224	breast	carcinoma; basal_(triple-negative)_carcinoma	Unknown
c.807G>C; p.T269T; 15:88135999-88135999	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1729C>T; p.P577S; 15:87933172-87933172	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1729C>T; p.P577S; 15:87933172-87933172	skin	malignant_melanoma	Substitution - Missense
c.2413G>A; p.E805K; 15:87877000-87877000	skin	malignant_melanoma	Substitution - Missense
c.940G>C; p.E314Q; 15:88135365-88135365	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.265C>T; p.R89C; 15:88184283-88184283	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1417G>T; p.G473C; 15:88033025-88033025	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1053A>T; p.E351D; 15:88135252-88135252	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.964G>A; p.E322K; 15:88135341-88135341	pancreas	NS	Substitution - Missense
c.2254T>C; p.Y752H; 15:87880308-87880308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.964G>A; p.E322K; 15:88135341-88135341	pancreas	carcinoma	Substitution - Missense
c.1304C>A; p.A435E; 15:88126363-88126363	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1008G>A; p.L336L; 15:88135297-88135297	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.457C>T; p.R153W; 15:88147342-88147342	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.2279T>C; p.L760P; 15:87880283-87880283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2279T>C; p.L760P; 15:87880283-87880283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.449T>C; p.L150P; 15:88147350-88147350	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>A; p.R731R; 15:87880371-87880371	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2191C>A; p.R731R; 15:87880371-87880371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2400G>T; p.R800R; 15:87877013-87877013	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2306T>A; p.I769N; 15:87877107-87877107	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2161C>A; p.R721S; 15:87880401-87880401	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.279G>A; p.T93T; 15:88184269-88184269	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1464C>T; p.I488I; 15:88032978-88032978	skin	malignant_melanoma	Substitution - coding silent
c.1464C>T; p.I488I; 15:88032978-88032978	skin	malignant_melanoma	Substitution - coding silent
c.2288C>T; p.T763M; 15:87880274-87880274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.785A>G; p.N262S; 15:88136021-88136021	ovary	other; neoplasm	Substitution - Missense
c.38_49del12; p.W13_F16delWRIF; 15:88256105-88256116	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.446C>G; p.T149R; 15:88147353-88147353	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.446C>G; p.T149R; 15:88147353-88147353	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.446C>G; p.T149R; 15:88147353-88147353	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1615G>A; p.V539M; 15:87940724-87940724	skin	malignant_melanoma	Substitution - Missense
c.1257C>T; p.I419I; 15:88127198-88127198	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1586-1G>T; p.?; 15:87940754-87940754	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1868G>A; p.G623E; 15:87933033-87933033	skin	malignant_melanoma	Substitution - Missense
c.2452C>T; p.P818S; 15:87876961-87876961	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1615G>A; p.V539M; 15:87940724-87940724	liver	carcinoma	Substitution - Missense
c.1760G>A; p.R587K; 15:87933141-87933141	skin	malignant_melanoma	Substitution - Missense
c.465-5G>A; p.?; 15:88137566-88137566	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1516A>G; p.T506A; 15:88032926-88032926	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.389G>A; p.R130H; 15:88183424-88183424	liver	carcinoma	Substitution - Missense
c.389G>A; p.R130H; 15:88183424-88183424	oesophagus	carcinoma	Substitution - Missense
c.454C>A; p.L152I; 15:88147345-88147345	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1990G>T; p.A664S; 15:87929334-87929334	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2192G>C; p.R731P; 15:87880370-87880370	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.962T>C; p.I321T; 15:88135343-88135343	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1487C>T; p.A496V; 15:88032955-88032955	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.249-6C>A; p.?; 15:88184305-88184305	pancreas	carcinoma	Unknown
c.2166G>T; p.W722C; 15:87880396-87880396	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.693C>T; p.C231C; 15:88136539-88136539	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1545G>T; p.Q515H; 15:88032897-88032897	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2270G>A; p.W757*; 15:87880292-87880292	skin	malignant_melanoma	Substitution - Nonsense
c.2134G>T; p.V712L; 15:87880428-87880428	skin	malignant_melanoma	Substitution - Missense
c.806C>T; p.T269M; 15:88136000-88136000	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.85G>A; p.V29M; 15:88256069-88256069	pancreas	carcinoma	Substitution - Missense
c.971T>C; p.V324A; 15:88135334-88135334	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>C; p.V273L; 15:88135989-88135989	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.581G>A; p.G194D; 15:88137445-88137445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.731T>C; p.I244T; 15:88136501-88136501	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.465-6C>T; p.?; 15:88137567-88137567	pancreas	carcinoma	Unknown
c.542A>G; p.K181R; 15:88137484-88137484	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.247A>T; p.I83L; 15:88255907-88255907	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1228+1G>T; p.?; 15:88128710-88128710	breast	carcinoma	Unknown
c.2143C>T; p.H715Y; 15:87880419-87880419	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.742C>A; p.L248M; 15:88136490-88136490	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1826A>T; p.D609V; 15:87933075-87933075	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1666G>T; p.E556*; 15:87940673-87940673	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.2121G>A; p.T707T; 15:87929203-87929203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1071G>T; p.E357D; 15:88135234-88135234	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>T; p.E556*; 15:87940673-87940673	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2347A>G; p.K783E; 15:87877066-87877066	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332A>T; p.K111M; 15:88183481-88183481	kidney	other; neoplasm	Substitution - Missense
c.117C>A; p.S39R; 15:88256037-88256037	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.887G>T; p.S296I; 15:88135919-88135919	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.27G>T; p.K9N; 15:88256127-88256127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1458C>T; p.H486H; 15:88032984-88032984	liver	carcinoma	Substitution - coding silent
c.1458C>T; p.H486H; 15:88032984-88032984	liver	carcinoma	Substitution - coding silent
c.1927C>A; p.Q643K; 15:87929397-87929397	pancreas	carcinoma	Substitution - Missense
c.1169C>T; p.T390I; 15:88135136-88135136	kidney	other; neoplasm	Substitution - Missense
c.1611C>T; p.D537D; 15:87940728-87940728	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1795C>T; p.H599Y; 15:87933106-87933106	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2192G>T; p.R731L; 15:87880370-87880370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1108C>A; p.H370N; 15:88135197-88135197	skin	malignant_melanoma	Substitution - Missense
c.1108C>A; p.H370N; 15:88135197-88135197	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2192G>T; p.R731L; 15:87880370-87880370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2110G>T; p.V704F; 15:87929214-87929214	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.348G>T; p.R116R; 15:88183465-88183465	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.550A>T; p.S184C; 15:88137476-88137476	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.627T>A; p.L209L; 15:88136605-88136605	skin	malignant_melanoma	Substitution - coding silent
c.560T>C; p.L187P; 15:88137466-88137466	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.782delC; p.N262fs*7; 15:88136024-88136024	prostate	carcinoma; adenocarcinoma	Deletion - Frameshift
c.245C>T; p.S82F; 15:88255909-88255909	skin	malignant_melanoma	Substitution - Missense
c.1375C>T; p.R459W; 15:88126292-88126292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1188C>T; p.L396L; 15:88135117-88135117	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1375C>T; p.R459W; 15:88126292-88126292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.157C>A; p.L53I; 15:88255997-88255997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.561C>T; p.L187L; 15:88137465-88137465	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1534G>A; p.E512K; 15:88032908-88032908	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2073G>A; p.L691L; 15:87929251-87929251	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.301C>A; p.L101I; 15:88184247-88184247	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1577C>A; p.P526Q; 15:88032865-88032865	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2011G>A; p.A671T; 15:87929313-87929313	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.458G>A; p.R153Q; 15:88147341-88147341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1382A>G; p.K461R; 15:88126285-88126285	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.350G>C; p.S117T; 15:88183463-88183463	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.506G>A; p.R169H; 15:88137520-88137520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2049G>C; p.R683S; 15:87929275-87929275	breast	carcinoma	Substitution - Missense
c.1954G>C; p.G652R; 15:87929370-87929370	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.963C>T; p.I321I; 15:88135342-88135342	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1811A>T; p.Y604F; 15:87933090-87933090	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1881G>A; p.K627K; 15:87933020-87933020	skin	malignant_melanoma	Substitution - coding silent
c.872G>C; p.G291A; 15:88135934-88135934	liver	carcinoma	Substitution - Missense
c.2441G>A; p.G814E; 15:87876972-87876972	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.681T>G; p.A227A; 15:88136551-88136551	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.107G>A; p.C36Y; 15:88256047-88256047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.872G>C; p.G291A; 15:88135934-88135934	liver	carcinoma	Substitution - Missense
c.1693G>C; p.D565H; 15:87940646-87940646	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2191C>T; p.R731W; 15:87880371-87880371	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1077C>T; p.S359S; 15:88135228-88135228	breast	carcinoma	Substitution - coding silent
c.2035G>A; p.D679N; 15:87929289-87929289	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.888T>G; p.S296R; 15:88135918-88135918	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2255A>G; p.Y752C; 15:87880307-87880307	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.627T>C; p.L209L; 15:88136605-88136605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2255A>G; p.Y752C; 15:87880307-87880307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2290G>A; p.E764K; 15:87880272-87880272	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2290G>A; p.E764K; 15:87880272-87880272	skin	malignant_melanoma	Substitution - Missense
c.1821C>T; p.C607C; 15:87933080-87933080	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.147C>T; p.D49D; 15:88256007-88256007	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.333G>T; p.K111N; 15:88183480-88183480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1456C>A; p.H486N; 15:88032986-88032986	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.881A>C; p.N294T; 15:88135925-88135925	thyroid	carcinoma	Substitution - Missense
c.11C>G; p.S4C; 15:88256143-88256143	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	pancreas	carcinoma	Substitution - Missense
c.2195A>C; p.K732T; 15:87880367-87880367	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2280C>A; p.L760L; 15:87880282-87880282	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1998T>C; p.G666G; 15:87929326-87929326	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2095G>A; p.G699S; 15:87929229-87929229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1811A>G; p.Y604C; 15:87933090-87933090	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.911C>T; p.P304L; 15:88135394-88135394	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1750G>A; p.D584N; 15:87933151-87933151	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1750G>A; p.D584N; 15:87933151-87933151	skin	malignant_melanoma	Substitution - Missense
c.1266C>T; p.T422T; 15:88127189-88127189	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.182A>G; p.D61G; 15:88255972-88255972	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.234G>A; p.R78R; 15:88255920-88255920	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.2033G>A; p.R678Q; 15:87929291-87929291	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.2033G>A; p.R678Q; 15:87929291-87929291	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.144G>A; p.P48P; 15:88256010-88256010	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.447G>C; p.T149T; 15:88147352-88147352	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1805A>C; p.K602T; 15:87933096-87933096	skin	malignant_melanoma	Substitution - Missense
c.182_183delAT; p.D61fs*76; 15:88255971-88255972	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1483G>T; p.D495Y; 15:88032959-88032959	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1732A>G; p.T578A; 15:87933169-87933169	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1145A>C; p.N382T; 15:88135160-88135160	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.848C>A; p.T283K; 15:88135958-88135958	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1525C>T; p.P509S; 15:88032917-88032917	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.749C>A; p.S250Y; 15:88136483-88136483	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1625_1643del19; p.R542fs*24; 15:87940696-87940714	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1825G>A; p.D609N; 15:87933076-87933076	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1825G>A; p.D609N; 15:87933076-87933076	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1038G>A; p.K346K; 15:88135267-88135267	skin	malignant_melanoma	Substitution - coding silent
c.1546T>C; p.Y516H; 15:88032896-88032896	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.20C>G; p.P7R; 15:88256134-88256134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2244G>T; p.E748D; 15:87880318-87880318	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.796A>G; p.I266V; 15:88136010-88136010	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.562T>C; p.Y188H; 15:88137464-88137464	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2403G>A; p.L801L; 15:87877010-87877010	skin	malignant_melanoma	Substitution - coding silent
c.667G>C; p.E223Q; 15:88136565-88136565	pancreas	carcinoma	Substitution - Missense
c.1822G>A; p.G608S; 15:87933079-87933079	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.917G>C; p.R306P; 15:88135388-88135388	breast	carcinoma	Substitution - Missense
c.2268A>G; p.P756P; 15:87880294-87880294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1822G>A; p.G608S; 15:87933079-87933079	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1822G>A; p.G608S; 15:87933079-87933079	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.790C>T; p.H264Y; 15:88136016-88136016	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.346C>T; p.R116W; 15:88183467-88183467	skin	malignant_melanoma	Substitution - Missense
c.1007T>A; p.L336Q; 15:88135298-88135298	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1007T>A; p.L336Q; 15:88135298-88135298	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1007T>A; p.L336Q; 15:88135298-88135298	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1007T>A; p.L336Q; 15:88135298-88135298	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1066G>A; p.G356R; 15:88135239-88135239	skin	malignant_melanoma	Substitution - Missense
c.895delC; p.L299fs*10; 15:88135911-88135911	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.360C>A; p.P120P; 15:88183453-88183453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.834T>C; p.N278N; 15:88135972-88135972	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.369T>G; p.F123L; 15:88183444-88183444	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1685C>T; p.P562L; 15:87940654-87940654	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1884C>T; p.F628F; 15:87933017-87933017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1884C>T; p.F628F; 15:87933017-87933017	skin	malignant_melanoma	Substitution - coding silent
c.1185C>T; p.F395F; 15:88135120-88135120	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1185C>T; p.F395F; 15:88135120-88135120	skin	malignant_melanoma	Substitution - coding silent
c.1767C>T; p.A589A; 15:87933134-87933134	oesophagus	carcinoma	Substitution - coding silent
c.1192G>A; p.E398K; 15:88135113-88135113	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1884C>T; p.F628F; 15:87933017-87933017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1371T>G; p.G457G; 15:88126296-88126296	pancreas	carcinoma	Substitution - coding silent
c.2235C>T; p.I745I; 15:87880327-87880327	skin	malignant_melanoma	Substitution - coding silent
c.1884C>T; p.F628F; 15:87933017-87933017	skin	malignant_melanoma	Substitution - coding silent
c.1584G>A; p.T528T; 15:88032858-88032858	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1165C>G; p.Q389E; 15:88135140-88135140	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2275C>T; p.Q759*; 15:87880287-87880287	skin	malignant_melanoma	Substitution - Nonsense
c.2275C>T; p.Q759*; 15:87880287-87880287	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1523T>C; p.I508T; 15:88032919-88032919	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.589C>T; p.L197F; 15:88137437-88137437	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1521C>A; p.R507R; 15:88032921-88032921	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.903C>G; p.V301V; 15:88135903-88135903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2030A>G; p.H677R; 15:87929294-87929294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.849G>A; p.T283T; 15:88135957-88135957	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015G>A; p.G339R; 15:88135290-88135290	skin	malignant_melanoma	Substitution - Missense
c.1990G>C; p.A664P; 15:87929334-87929334	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.810G>A; p.L270L; 15:88135996-88135996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.810G>A; p.L270L; 15:88135996-88135996	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.622+2T>C; p.?; 15:88137402-88137402	stomach	carcinoma; adenocarcinoma	Unknown
c.919G>C; p.V307L; 15:88135386-88135386	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.919G>C; p.V307L; 15:88135386-88135386	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.919G>C; p.V307L; 15:88135386-88135386	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.919G>C; p.V307L; 15:88135386-88135386	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1870G>T; p.D624Y; 15:87933031-87933031	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1441C>G; p.L481V; 15:88033001-88033001	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2232G>A; p.V744V; 15:87880330-87880330	skin	malignant_melanoma	Substitution - coding silent
c.1191G>T; p.K397N; 15:88135114-88135114	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2255A>T; p.Y752F; 15:87880307-87880307	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1191G>T; p.K397N; 15:88135114-88135114	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1058A>T; p.Y353F; 15:88135247-88135247	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1192G>C; p.E398Q; 15:88135113-88135113	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.558C>T; p.N186N; 15:88137468-88137468	skin	malignant_melanoma	Substitution - coding silent
c.1139C>T; p.A380V; 15:88135166-88135166	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1561C>A; p.H521N; 15:88032881-88032881	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1139C>T; p.A380V; 15:88135166-88135166	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2458T>A; p.Y820N; 15:87876955-87876955	skin	malignant_melanoma	Substitution - Missense
c.1764G>A; p.E588E; 15:87933137-87933137	skin	malignant_melanoma	Substitution - coding silent
c.1746G>A; p.R582R; 15:87933155-87933155	skin	malignant_melanoma	Substitution - coding silent
c.194G>A; p.S65N; 15:88255960-88255960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2103C>T; p.S701S; 15:87929221-87929221	skin	malignant_melanoma	Substitution - coding silent
c.1204+10G>A; p.?; 15:88135091-88135091	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.168C>A; p.L56L; 15:88255986-88255986	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - coding silent
c.613A>G; p.S205G; 15:88137413-88137413	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.861G>C; p.E287D; 15:88135945-88135945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.698G>T; p.G233V; 15:88136534-88136534	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1821C>A; p.C607*; 15:87933080-87933080	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1366T>C; p.Y456H; 15:88126301-88126301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1398T>A; p.G466G; 15:88033044-88033044	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2148C>A; p.T716T; 15:87880414-87880414	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.454C>T; p.L152F; 15:88147345-88147345	skin	malignant_melanoma	Substitution - Missense
c.454C>T; p.L152F; 15:88147345-88147345	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1863G>T; p.K621N; 15:87933038-87933038	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1830G>T; p.G610G; 15:87933071-87933071	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.678C>T; p.N226N; 15:88136554-88136554	thyroid	other; neoplasm	Substitution - coding silent
c.2342G>T; p.C781F; 15:87877071-87877071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1972C>A; p.H658N; 15:87929352-87929352	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2094C>T; p.F698F; 15:87929230-87929230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2094C>T; p.F698F; 15:87929230-87929230	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1609G>T; p.D537Y; 15:87940730-87940730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2094C>T; p.F698F; 15:87929230-87929230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.724G>A; p.D242N; 15:88136508-88136508	skin	malignant_melanoma	Substitution - Missense
c.1955G>T; p.G652V; 15:87929369-87929369	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2133+1G>A; p.?; 15:87929190-87929190	skin	malignant_melanoma	Unknown
c.861G>T; p.E287D; 15:88135945-88135945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1633G>T; p.G545C; 15:87940706-87940706	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.633G>T; p.E211D; 15:88136599-88136599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.688A>T; p.T230S; 15:88136544-88136544	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]