| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5300 |
Name | PIN1 |
Synonymous | peptidylprolyl cis/trans isomerase, NIMA-interacting 1;PIN1;peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
Definition | PPIase Pin1|peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|rotamase Pin1 |
Position | 19p13 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
There is no record for PIN1 |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.323C>A; p.S108*; 19:9848081-9848081 |
skin; ear | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.445C>T; p.P149S; 19:9849152-9849152 |
skin; abdomen | malignant_melanoma | Substitution - Missense |
c.97C>A; p.Q33K; 19:9838474-9838474 |
skin; ear | carcinoma; squamous_cell_carcinoma | Substitution - Missense |