| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5300 |
Name | PIN1 |
Synonymous | DOD|UBL5;peptidylprolyl cis/trans isomerase, NIMA-interacting 1;PIN1;peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
Definition | PPIase Pin1|peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|rotamase Pin1 |
Position | 19p13 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
Pin1(h) + Tau(h){pT231} <==> Pin1(h):Tau(h){pT231} (binding; isomerization) | Pin1(h) + Rab4(h){p} <==> Pin1(h):Rab4(h){p} (binding) | Pin1(h) + p70S6K1-alpha2(h){p} <==> Pin1(h):p70S6K1-alpha2(h){p} (binding) | Pin1(h) + Cdc25C(h){p} <==> Pin1(h):Cdc25C(h){p} (binding; isomerization) | Pin1(h) + plk1(h){p} <==> Pin1(h):plk1(h){p} (binding; isomerization) | Pin1(h) + pkmyt1(h){p} <==> Pin1(h):pkmyt1(h){p} (binding) | c-Jun(h){pS63}{pS73} + Pin1(h) <==> c-Jun(h){pS63}{pS73}:Pin1(h) (binding) | NIMA(an) + Pin1(h) <==> NIMA(an):Pin1(h) (binding) | beta-catenin(h){pS146} + Pin1(h) <==> beta-catenin(h){pS146}:Pin1(h) (binding; translocation) | Pin1(h) --> HSPA5(h) (transactivation) | Pin1(h) --> profilin(h) (activation; expression) | NHERF-1(h){p} + Pin1(h) <==> NHERF-1(h){p}:Pin1(h) (binding) | p73(h) + Pin1(h) <==> p73(h):Pin1(h) (binding) | p53(h) + Pin1(h) <==> p53(h):Pin1(h) (binding) | p53(m) + Pin1(h) <==> p53(m):Pin1(h) (binding) | p53(h){pS33}{pT81}{pS315} + Pin1(h) <==> p53(h){pS33}{pT81}{pS315}:Pin1(h) (binding) | p73alpha(h){pS412}{pT442}{pT482} + Pin1(h) <==> p73alpha(h){pS412}{pT442}{pT482}:Pin1(h) (binding) | p73beta(h) + Pin1(h) <==> p73beta(h):Pin1(h) (binding) | PC3(v.s.){p} + Pin1(h) <==> PC3(v.s.){p}:Pin1(h) (binding) | Pin1(h) --> Pin1(h) (translocation) | Pin1(h) + BimL(v.s.) <==> Pin1(h):BimL(v.s.) (binding) | Pin1(h) + BOD-L(r) <==> Pin1(h):BOD-L(r) (binding) | Pin1(h) + BimEL(ha) <==> Pin1(h):BimEL(ha) (binding) | Pin1(h) + RelA-p65(h) <==> Pin1(h):RelA-p65(h) (binding) | cyclinD1(m.s.){pT286} + Pin1(h) <==> cyclinD1(m.s.){pT286}:Pin1(h) (binding) | VHL(h) + Pin1(h) <==> VHL(h):Pin1(h) (binding) | hnRNP-C(h) + Pin1(h) <==> hnRNP-C(h):Pin1(h) (binding) | I-MF(h) + Pin1(h) <==> I-MF(h):Pin1(h) (binding) | p54nrb/NonO(h) + Pin1(h) <==> p54nrb/NonO(h):Pin1(h) (binding) | Pin1(h) + CtIP(h) <==> Pin1(h):CtIP(h) (binding) | Pin1(h) + TRAF2(h) <==> Pin1(h):TRAF2(h) (binding) | Pin1(h) + rai1(h) <==> Pin1(h):rai1(h) (binding) | Pin1(h) + rbpms(h) <==> Pin1(h):rbpms(h) (binding) | Pin1(h) + gga2(h) <==> Pin1(h):gga2(h) (binding) | Pin1(h) + Tilz2(h) <==> Pin1(h):Tilz2(h) (binding) | Pin1(h) + Zimp7(h) <==> Pin1(h):Zimp7(h) (binding) | Pin1(h) + foxo4(h) <==> Pin1(h):foxo4(h) (binding) | Mcl-1(h) + Pin1(h) <==> Mcl-1(h):Pin1(h) (binding) | Pin1(h) + PML(h) <==> Pin1(h):PML(h) (binding) | SRC3(h) + Pin1(h) <==> SRC3(h):Pin1(h) (binding) | Pin1(h) + IRF-3(h) <==> Pin1(h):IRF-3(h) (binding) | Pin1(h) --> (IRF-3(h))2 (decrease of oligomerization) | Pin1(h) --> IRF-3(h){ub}n (increase of ubiquitination) | Pin1(h) --/ IFNbeta(h) (decrease of abundance) | Pin1(h) + ATP --> Pin1(h){pS16} + ADP (phosphorylation) | SOCS-3(h) + Pin1(h) <==> SOCS-3(h):Pin1(h) (binding) | TRF1(h) + Pin1(h) <==> TRF1(h):Pin1(h) (binding) | Pin1(h):Tau(h){pT231} --PP2A(pg)--> Pin1(h) + Tau(h) + p (dephosphorylation; dissociation) | Pin1(h):Cdc25C(h){p} --PP2A(pg)--> Pin1(h) + Cdc25C(h) + p (dephosphorylation; dissociation) | brca1(h) --/ Pin1(h) (inhibition) | PIN1(h) --> Pin1(h) (expression). | Pin1(h) --> Pin1(h) (translocation) | plk1(h) --> Pin1(h) (increase of abundance) | E2F-1(m.s.) --> Pin1(h) (increase of abundance) | ErbB2(m.s.) --> Pin1(h) (increase of abundance) | H-Ras(m.s.) --> Pin1(h) (increase of abundance) | Pin1(h) + N-Myc(m) <==> Pin1(h):N-Myc(m) (binding) | N-Myc(m) + Pin1(h) <==> N-Myc(m):Pin1(h) (binding) | Tau-F(h){pT212}{pS214} + Pin1(h) <==> Tau-F(h){pT212}{pS214}:Pin1(h) (binding) | Tau-F(h){pT231} + Pin1(h) <==> Tau-F(h){pT231}:Pin1(h) (binding) | Tau-F(h){pT212}{pS214}{pT231} + Pin1(h) <==> Tau-F(h){pT212}{pS214}{pT231}:Pin1(h) (binding) | plk1(h) + Pin1(h) <==> plk1(h):Pin1(h) (binding) | Pin1(h) + ATP --plk1(m.s.)--> Pin1(h){pS65} + ADP (phosphorylation) | Pin1(h) + ubiquitin(h) --> Pin1(h){ub} (ubiquitination) | c-Fos(m) + Pin1(h) <==> c-Fos(m):Pin1(h) (binding) | c-Fos(m){pT232}{pT325}{pT331}{pS374} + Pin1(h) <==> c-Fos(m){pT232}{pT325}{pT331}{pS374}:Pin1(h) (binding) | Pin1(h) --> cyclinD1(h) (increase of abundance) | Emi1(x) + Pin1(h) <==> Emi1(x):Pin1(h) (binding) | AATF(h){p} + Pin1(h) <==> AATF(h){p}:Pin1(h) (binding) | Pin1(h) + SRC3(h) <==> Pin1(h):SRC3(h) (binding) | Pin1(h) + SRC3(m.s.) <==> Pin1(h):SRC3(m.s.) (binding) | Pin1(h) --/ SRC3(m.s.) (decrease of abundance) | PIN1(h) --> Pin1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
65 | Phosphoserine (PLK1) | 16118204 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 9805499 - 9807499 | Agilent_014791 |
chr19 |
Promoter: 9805499 - 9807499 | GSE27584 |
chr19 |
Promoter: 9805499 - 9807499 | Agilent_014791_44K |