General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
|
---|---|
Gene ID | 5468 |
Name | PPARG |
Synonymous | peroxisome proliferator-activated receptor gamma;PPARG;peroxisome proliferator-activated receptor gamma |
Definition | PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1 |
Position | 3p25 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
Loss of Function mutations compare to missense mutations | Top |
The ratio of the loss-of-function mutations over missense mutations is 0.09. |
The copy number variations for various cancers | Top |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
---|---|---|---|
c.254G>A; p.R85K; 3:12379875-12379875 |
skin | malignant_melanoma | Substitution - Missense |
c.637A>G; p.M213V; 3:12405899-12405899 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.703G>A; p.E235K; 3:12405965-12405965 |
skin | malignant_melanoma | Substitution - Missense |
c.1105A>T; p.I369L; 3:12416989-12416989 |
liver | carcinoma | Substitution - Missense |
c.1105A>T; p.I369L; 3:12416989-12416989 |
liver | carcinoma | Substitution - Missense |
c.686T>C; p.I229T; 3:12405948-12405948 |
liver | carcinoma | Substitution - Missense |
c.686T>C; p.I229T; 3:12405948-12405948 |
liver | carcinoma | Substitution - Missense |
c.1295A>C; p.K432T; 3:12433922-12433922 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.946C>T; p.R316C; 3:12416830-12416830 |
skin | malignant_melanoma | Substitution - Missense |
c.669G>A; p.A223A; 3:12405931-12405931 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.669G>A; p.A223A; 3:12405931-12405931 |
skin | malignant_melanoma | Substitution - coding silent |
c.1190A>G; p.E397G; 3:12417074-12417074 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.553A>G; p.K185E; 3:12392686-12392686 |
lung; right_lower_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.3G>A; p.M1I; 3:12351595-12351595 |
skin | malignant_melanoma | Substitution - Missense |
c.1114G>A; p.G372S; 3:12416998-12416998 |
skin | malignant_melanoma | Substitution - Missense |
c.3G>A; p.M1I; 3:12351595-12351595 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1114G>A; p.G372S; 3:12416998-12416998 |
skin | malignant_melanoma | Substitution - Missense |
c.1452C>A; p.I484I; 3:12434079-12434079 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1248T>A; p.I416I; 3:12417132-12417132 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1481A>C; p.H494P; 3:12434108-12434108 |
pancreas | carcinoma | Substitution - Missense |
c.1104C>T; p.L368L; 3:12416988-12416988 |
skin | malignant_melanoma | Substitution - coding silent |
c.765G>T; p.P255P; 3:12406027-12406027 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.789G>A; p.A263A; 3:12406051-12406051 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.845C>T; p.S282F; 3:12416729-12416729 |
skin | malignant_melanoma | Substitution - Missense |
c.845C>T; p.S282F; 3:12416729-12416729 |
skin | malignant_melanoma | Substitution - Missense |
c.746C>T; p.S249L; 3:12406008-12406008 |
kidney | other; neoplasm | Substitution - Missense |
c.290T>G; p.L97R; 3:12379911-12379911 |
breast | carcinoma; ductal_carcinoma | Substitution - Missense |
c.179T>G; p.F60C; 3:12379800-12379800 |
skin | malignant_melanoma | Substitution - Missense |
c.448C>T; p.H150Y; 3:12381459-12381459 |
skin; face | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.998G>A; p.G333D; 3:12416882-12416882 |
skin | malignant_melanoma | Substitution - Missense |
c.1484C>G; p.P495R; 3:12434111-12434111 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1460C>T; p.T487M; 3:12434087-12434087 |
stomach | adenocarcinoma | Substitution - Missense |
c.605G>A; p.G202E; 3:12392738-12392738 |
skin | malignant_melanoma | Substitution - Missense |
c.491G>A; p.R164Q; 3:12392624-12392624 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.550delA; p.S186fs*47; 3:12392683-12392683 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.550delA; p.S186fs*47; 3:12392683-12392683 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.657G>A; p.E219E; 3:12405919-12405919 |
skin | malignant_melanoma | Substitution - coding silent |
c.186C>T; p.I62I; 3:12379807-12379807 |
skin | malignant_melanoma | Substitution - coding silent |
c.11C>G; p.T4S; 3:12351603-12351603 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.641C>T; p.P214L; 3:12405903-12405903 |
skin | malignant_melanoma | Substitution - Missense |
c.1059C>T; p.I353I; 3:12416943-12416943 |
skin | malignant_melanoma | Substitution - coding silent |
c.77C>T; p.S26L; 3:12351669-12351669 |
skin | malignant_melanoma | Substitution - Missense |
c.783G>C; p.A261A; 3:12406045-12406045 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1054G>A; p.E352K; 3:12416938-12416938 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.75A>T; p.I25I; 3:12351667-12351667 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1348A>C; p.K450Q; 3:12433975-12433975 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1348A>C; p.K450Q; 3:12433975-12433975 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1348A>C; p.K450Q; 3:12433975-12433975 |
large_intestine; colon | carcinoma | Substitution - Missense |
c.1348A>C; p.K450Q; 3:12433975-12433975 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1402A>G; p.T468A; 3:12434029-12434029 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.37G>T; p.E13*; 3:12351629-12351629 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.922C>T; p.R308C; 3:12416806-12416806 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - Missense |
c.922C>T; p.R308C; 3:12416806-12416806 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.109C>T; p.P37S; 3:12379730-12379730 |
skin | malignant_melanoma | Substitution - Missense |
c.109C>T; p.P37S; 3:12379730-12379730 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1067C>A; p.T356K; 3:12416951-12416951 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1230C>T; p.S410S; 3:12417114-12417114 |
central_nervous_system; brain | glioma | Substitution - coding silent |
c.1480C>T; p.H494Y; 3:12434107-12434107 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.327G>A; p.E109E; 3:12381338-12381338 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.398_399CC>TT; p.S133F; 3:12381409-12381410 |
skin | malignant_melanoma | Substitution - Missense |
c.1095T>C; p.D365D; 3:12416979-12416979 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.298C>T; p.Q100*; 3:12379919-12379919 |
skin | malignant_melanoma | Substitution - Nonsense |
c.1094A>G; p.D365G; 3:12416978-12416978 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.399C>T; p.S133S; 3:12381410-12381410 |
skin | malignant_melanoma | Substitution - coding silent |
c.668C>T; p.A223V; 3:12405930-12405930 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.668C>T; p.A223V; 3:12405930-12405930 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.668C>T; p.A223V; 3:12405930-12405930 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.556A>G; p.S186G; 3:12392689-12392689 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.556A>G; p.S186G; 3:12392689-12392689 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.556A>G; p.S186G; 3:12392689-12392689 |
stomach | adenocarcinoma | Substitution - Missense |
c.724C>G; p.L242V; 3:12405986-12405986 |
breast | carcinoma | Substitution - Missense |
c.724C>G; p.L242V; 3:12405986-12405986 |
breast | carcinoma | Substitution - Missense |
c.882C>T; p.H294H; 3:12416766-12416766 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.168C>G; p.H56Q; 3:12379789-12379789 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.532C>A; p.L178I; 3:12392665-12392665 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.176C>T; p.S59F; 3:12379797-12379797 |
skin; mucosal | malignant_melanoma | Substitution - Missense |
c.455G>A; p.G152E; 3:12381466-12381466 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.480+7delA; p.?; 3:12381498-12381498 |
NS | malignant_melanoma | Unknown |
c.303G>A; p.E101E; 3:12379924-12379924 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.887delC; p.L298fs*38; 3:12416771-12416771 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.887delC; p.L298fs*38; 3:12416771-12416771 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.648C>A; p.A216A; 3:12405910-12405910 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1270+1G>A; p.?; 3:12417155-12417155 |
skin | malignant_melanoma | Unknown |
c.1477C>T; p.L493F; 3:12434104-12434104 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1154G>A; p.R385Q; 3:12417038-12417038 |
skin | malignant_melanoma | Substitution - Missense |
c.682G>T; p.D228Y; 3:12405944-12405944 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1515C>G; p.Y505*; 3:12434142-12434142 |
ovary | other; neoplasm | Substitution - Nonsense |
c.1515C>G; p.Y505*; 3:12434142-12434142 |
ovary | other; neoplasm | Substitution - Nonsense |
c.1515C>G; p.Y505*; 3:12434142-12434142 |
ovary | other; neoplasm | Substitution - Nonsense |
c.1515C>G; p.Y505*; 3:12434142-12434142 |
ovary | other; neoplasm | Substitution - Nonsense |
c.169T>A; p.S57T; 3:12379790-12379790 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.235G>A; p.E79K; 3:12379856-12379856 |
breast | carcinoma | Substitution - Missense |
c.1431C>T; p.H477H; 3:12434058-12434058 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.1431C>T; p.H477H; 3:12434058-12434058 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.870C>G; p.I290M; 3:12416754-12416754 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.177C>A; p.S59S; 3:12379798-12379798 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.672G>A; p.E224E; 3:12405934-12405934 |
skin | malignant_melanoma | Substitution - coding silent |
c.262C>G; p.P88A; 3:12379883-12379883 |
central_nervous_system; brain | glioma | Substitution - Missense |
c.1413A>G; p.R471R; 3:12434040-12434040 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.940C>G; p.Q314E; 3:12416824-12416824 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.940C>G; p.Q314E; 3:12416824-12416824 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.7G>A; p.E3K; 3:12351599-12351599 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.7G>A; p.E3K; 3:12351599-12351599 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.7G>A; p.E3K; 3:12351599-12351599 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.1462G>A; p.E488K; 3:12434089-12434089 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.419G>A; p.R140H; 3:12381430-12381430 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |