| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5468 |
Name | PPARG |
Synonymous | CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma;peroxisome proliferator-activated receptor gamma;PPARG;peroxisome proliferator-activated receptor gamma |
Definition | PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1 |
Position | 3p25 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
PPARgamma1(h) + ATP --ERK2(m){p}--> PPARgamma1(h){p} + ADP (phosphorylation) | PPARgamma1(h) + ATP --JNK(v.s.)--> PPARgamma1(h){p} + ADP (phosphorylation) | PPARgamma1(h) + CBP(h) <==> PPARgamma1(h):CBP(h) (binding) | RXR-alpha(h) + PPARgamma1(h) <==> RXR-alpha(h):PPARgamma1(h) (binding). | PPARgamma1(h) + COPR1(h) <==> PPARgamma1(h):COPR1(h) (binding) | PPARgamma1(h) + COPR2(h) <==> PPARgamma1(h):COPR2(h) (binding) | phytanic acid + PPARgamma1(h) <==> phytanic acid:PPARgamma1(h) (binding) | 3S,7R,11R phytanic acid + PPARgamma1(h) <==> 3S,7R,11R phytanic acid:PPARgamma1(h) (binding) | 3R,7R,11R phytanic acid + PPARgamma1(h) <==> 3R,7R,11R phytanic acid:PPARgamma1(h) (binding) | cervonic acid + PPARgamma1(h) <==> cervonic acid:PPARgamma1(h) (binding) | linoleic acid + PPARgamma1(h) <==> linoleic acid:PPARgamma1(h) (binding) | PGA1 + PPARgamma1(h) <==> PGA1:PPARgamma1(h) (binding) | 15d-PGJ2 + PPARgamma1(h) <==> 15d-PGJ2:PPARgamma1(h) (binding) | arachidonic acid + PPARgamma1(h) <==> arachidonic acid:PPARgamma1(h) (binding) | gamma-linolenic acid + PPARgamma1(h) <==> gamma-linolenic acid:PPARgamma1(h) (binding) | 13(S)-HODE + PPARgamma1(h) <==> 13(S)-HODE:PPARgamma1(h) (binding) | 15-HETE + PPARgamma1(h) <==> 15-HETE:PPARgamma1(h) (binding) | PPARgamma1(h) + CBP(m.s.) <==> PPARgamma1(h):CBP(m.s.) (binding) | LPA + PPARgamma1(h) <==> LPA:PPARgamma1(h) (binding) | palmitoyl LPA + PPARgamma1(h) <==> palmitoyl LPA:PPARgamma1(h) (binding) | oleoyl LPA + PPARgamma1(h) <==> oleoyl LPA:PPARgamma1(h) (binding) | 9-HODE + PPARgamma1(h) <==> 9-HODE:PPARgamma1(h) (binding) | 13-HODE + PPARgamma1(h) <==> 13-HODE:PPARgamma1(h) (binding) | nitrolinoleic acid + PPARgamma1(h) <==> nitrolinoleic acid:PPARgamma1(h) (binding) | azPC + PPARgamma1(h) <==> azPC:PPARgamma1(h) (binding) | 13-OxoODE + PPARgamma1(h) <==> 13-OxoODE:PPARgamma1(h) (binding) | 9-oxoODE + PPARgamma1(h) <==> 9-oxoODE:PPARgamma1(h) (binding) | 5-oxo-ETE + PPARgamma1(h) <==> 5-oxo-ETE:PPARgamma1(h) (binding) | 15-oxoETE + PPARgamma1(h) <==> 15-oxoETE:PPARgamma1(h) (binding) | 15-oxoEDE + PPARgamma1(h) <==> 15-oxoEDE:PPARgamma1(h) (binding) | 15-keto-PGE1 + PPARgamma1(h) <==> 15-keto-PGE1:PPARgamma1(h) (binding) | 15-keto-PGF1alpha + PPARgamma1(h) <==> 15-keto-PGF1alpha:PPARgamma1(h) (binding) | oleic acid + PPARgamma1(h) <==> oleic acid:PPARgamma1(h) (binding) | AGP + PPARgamma1(h) <==> AGP:PPARgamma1(h) (binding) | AGP18.1 + PPARgamma1(h) <==> AGP18.1:PPARgamma1(h) (binding) | stearoyl-LPA + PPARgamma1(h) <==> stearoyl-LPA:PPARgamma1(h) (binding) | cPA + PPARgamma1(h) <==> cPA:PPARgamma1(h) (binding) | AGP16.0 + PPARgamma1(h) <==> AGP16.0:PPARgamma1(h) (binding) | PGJ2 + PPARgamma1(h) <==> PGJ2:PPARgamma1(h) (binding) | delta-12-PGJ2 + PPARgamma1(h) <==> delta-12-PGJ2:PPARgamma1(h) (binding) | PDIP1(h) + PPARgamma1(h) <==> PDIP1(h):PPARgamma1(h) (binding) | PDIP1-beta(h) + PPARgamma1(h) <==> PDIP1-beta(h):PPARgamma1(h) (binding) | NCOR(h) + PPARgamma1(h) <==> NCOR(h):PPARgamma1(h) (binding) | MEK1(h) + PPARgamma1(h) <==> MEK1(h):PPARgamma1(h) (binding) | PPARgamma1(h) --> Acox1(r) (DNA binding). | PPARG(h) --> PPARgamma1(h) (expression). | p300(h) + PPARgamma2(h) <==> p300(h):PPARgamma2(h) (binding) | PGC-1(m) + PPARgamma2(h) <==> PGC-1(m):PPARgamma2(h) (binding) | RXR-alpha(m) + PPARgamma2(h) <==> RXR-alpha(m):PPARgamma2(h) (binding). | RXR-alpha(h) + PPARgamma2(h) <==> RXR-alpha(h):PPARgamma2(h) (binding). | MBF-1alpha(h) + PPARgamma2(h) <==> MBF-1alpha(h):PPARgamma2(h) (binding) | SRC-1(h) + PPARgamma2(h) <==> SRC-1(h):PPARgamma2(h) (binding) | PPARgamma2(h) + TIF2(h) <==> PPARgamma2(h):TIF2(h) (binding) | PPARgamma2(h) + SRC3(h) <==> PPARgamma2(h):SRC3(h) (binding) | PPARgamma2(h) + DRIP205(h) <==> PPARgamma2(h):DRIP205(h) (binding) | cyclinD3(r) + PPARgamma2(h) <==> cyclinD3(r):PPARgamma2(h) (binding) | PPARgamma2(h) + ATP --Cdk6(m.s.):cyclinD3(m.s.)--> PPARgamma2(h){p} + ADP (phosphorylation) | PPARgamma2(h) + SDP1(h) <==> PPARgamma2(h):SDP1(h) (binding) | PPARgamma2(h) + PGC-2(m) <==> PPARgamma2(h):PGC-2(m) (binding) | PPARgamma2(h) + BAF60c2(h) <==> PPARgamma2(h):BAF60c2(h) (binding) | PPARgamma2(h) + BAF60c1(h) <==> PPARgamma2(h):BAF60c1(h) (binding) | p300(m.s.) + PPARgamma2(h) <==> p300(m.s.):PPARgamma2(h) (binding) | PPARgamma2(h) + CAP350(h) <==> PPARgamma2(h):CAP350(h) (binding) | anandamide + PPARgamma2(h) <==> anandamide:PPARgamma2(h) (binding) | 15d-PGJ2 + PPARgamma2(h) <==> 15d-PGJ2:PPARgamma2(h) (binding) | linolenic acid + PPARgamma2(h) <==> linolenic acid:PPARgamma2(h) (binding) | PGJ2 + PPARgamma2(h) <==> PGJ2:PPARgamma2(h) (binding) | RA + PPARgamma2(h) <==> RA:PPARgamma2(h) (binding) | linoleic acid + PPARgamma2(h) <==> linoleic acid:PPARgamma2(h) (binding) | PGH1 + PPARgamma2(h) <==> PGH1:PPARgamma2(h) (binding) | PGH2 + PPARgamma2(h) <==> PGH2:PPARgamma2(h) (binding) | SRC-1(m.s.) + PPARgamma2(h) <==> SRC-1(m.s.):PPARgamma2(h) (binding) | TIF2(m.s.) + PPARgamma2(h) <==> TIF2(m.s.):PPARgamma2(h) (binding) | PPARgamma2(h) --> Bace1(r) (DNA binding). | PPARG(h) --> PPARgamma2(h) (expression). | PPARgamma(h) + SRC-1(h) <==> SRC-1(h):(PPARgamma(h))2 (binding) | 15d-PGJ2 + PPARgamma(h) <==> 15d-PGJ2:PPARgamma(h) (binding) | PPARgamma(h) + NF-AT2(h) <==> PPARgamma(h):NF-AT2(h) (binding) | PPARgamma(h) + RXR-alpha(h) <==> PPARgamma(h):RXR-alpha(h) (binding). | PPARgamma(h) + CBP(h) <==> PPARgamma(h):CBP(h) (binding). | RXR-alpha(m) + PPARgamma(h) <==> RXR-alpha(m):PPARgamma(h) (binding) | PPARgamma(h) + p85(h) + ER-alpha(h) <==> PPARgamma(h):p85(h):ER-alpha(h) (binding) | ASC-2-isoform1(m) + PPARgamma(h) <==> ASC-2-isoform1(m):PPARgamma(h) (binding) | PPARgamma(h) + ERK5(h) <==> PPARgamma(h):ERK5(h) (binding) | PPARgamma(h) --> KRT20(h) (transactivation) | PPARgamma(h) --> FABP1(h) (transactivation) | PPARgamma(h) --> KLF4(h) (transactivation) | PPARgamma(h) --> ADFP(h) (transactivation) | PPARgamma(h) --> CEACAM1(h) (transactivation) | PPARgamma(h) --> CEACAM5(h) (transactivation) | PPARgamma(h) --> ANXA1(h) (transactivation) | PPARgamma(h) --> ANXA2(h) (transactivation) | PPARgamma(h) --> Keratin-20(h) (increase of abundance) | BRG1(h) + BAF60c2(h) + BAF60c1(h) + PPARgamma(h) <==> BRG1(h):BAF60c2(h):BAF60c1(h):PPARgamma(h) (binding) | PPARgamma(h) --> TNFRSF17(m) (DNA binding). | PPARgamma(h) + LXR-alpha(h) <==> PPARgamma(h):LXR-alpha(h) (binding) | PPARgamma(h) + LXR-beta(h) <==> PPARgamma(h):LXR-beta(h) (binding) | PPARgamma(h) + PDK1(h) <==> PPARgamma(h):PDK1(h) (binding) | gamma-linolenic acid + PPARgamma(h) <==> gamma-linolenic acid:PPARgamma(h) (binding) | dihomo-gamma-linolenic acid + PPARgamma(h) <==> dihomo-gamma-linolenic acid:PPARgamma(h) (binding) | arachidonic acid + PPARgamma(h) <==> arachidonic acid:PPARgamma(h) (binding) | eicosapentaenoic acid + PPARgamma(h) <==> eicosapentaenoic acid:PPARgamma(h) (binding) | 11,12-EET + PPARgamma(h) <==> 11,12-EET:PPARgamma(h) (binding) | 11,12-EEZE + PPARgamma(h) <==> 11,12-EEZE:PPARgamma(h) (binding) | 14,15-EET + PPARgamma(h) <==> 14,15-EET:PPARgamma(h) (binding) | 11,12-DHET + PPARgamma(h) <==> 11,12-DHET:PPARgamma(h) (binding) | 14,15-DHET + PPARgamma(h) <==> 14,15-DHET:PPARgamma(h) (binding) | 20-HETE + PPARgamma(h) <==> 20-HETE:PPARgamma(h) (binding) | nitrolinoleic acid + PPARgamma(h) <==> nitrolinoleic acid:PPARgamma(h) (binding) | 9-oxoODE + PPARgamma(h) <==> 9-oxoODE:PPARgamma(h) (binding) | linoleic acid + PPARgamma(h) <==> linoleic acid:PPARgamma(h) (binding) | cis-parinaric acid + PPARgamma(h) <==> cis-parinaric acid:PPARgamma(h) (binding) | palmitic acid + PPARgamma(h) <==> palmitic acid:PPARgamma(h) (binding) | oleic acid + PPARgamma(h) <==> oleic acid:PPARgamma(h) (binding) | geraniol + PPARgamma(h) <==> geraniol:PPARgamma(h) (binding) | farnesol + PPARgamma(h) <==> farnesol:PPARgamma(h) (binding) | geranylgeraniol + PPARgamma(h) <==> geranylgeraniol:PPARgamma(h) (binding) | nitrated oleic acid + PPARgamma(h) <==> nitrated oleic acid:PPARgamma(h) (binding) | phytol + PPARgamma(h) <==> phytol:PPARgamma(h) (binding) | 15(S)-HETE + PPARgamma(h) <==> 15(S)-HETE:PPARgamma(h) (binding) | cervonic acid + PPARgamma(h) <==> cervonic acid:PPARgamma(h) (binding) | MEK1(h) + PPARgamma(h) <==> MEK1(h):PPARgamma(h) (binding) | PPARgamma(h) --> PPARgamma(h) (translocation) | PPARgamma(h) + RFX5(m.s.) <==> PPARgamma(h):RFX5(m.s.) (binding) | PPARgamma(h) --/ COL1A1(h) (transrepression) | PPARgamma(h) --/ COL1A2(h) (transrepression) | PPARgamma(h) + C2TA(m.s.) <==> PPARgamma(h):C2TA(m.s.) (binding) | PPARgamma(h) + C2TA(h) <==> PPARgamma(h):C2TA(h) (binding) | PPARgamma(h) + RFX5(h) <==> PPARgamma(h):RFX5(h) (binding) | abietic acid + PPARgamma(h) <==> abietic acid:PPARgamma(h) (binding) | PPARgamma(h) --> Bace1(r) (DNA binding). | PPARgamma(h) + p53(h) <==> PPARgamma(h):p53(h) (binding) | SRC-1(h) + PPARgamma(h) <==> SRC-1(h):PPARgamma(h) (binding) | PPARgamma(h) + DRIP205(h) <==> PPARgamma(h):DRIP205(h) (binding) | PPARgamma(h) + ASC-2(h) <==> PPARgamma(h):ASC-2(h) (binding) | PPARgamma(h) + NCOR1(h) <==> PPARgamma(h):NCOR1(h) (binding) | SMRT(h) + PPARgamma(h) <==> SMRT(h):PPARgamma(h) (binding) | PPARgamma(h) + DAX1(h) <==> PPARgamma(h):DAX1(h) (binding) | PPARgamma(h) + FHOS(h) <==> PPARgamma(h):FHOS(h) (binding) | PPARgamma(h) + ATSV(h) <==> PPARgamma(h):ATSV(h) (binding) | PPARgamma(h) + JAB1(h) <==> PPARgamma(h):JAB1(h) (binding) | PPARgamma(h) + RanBPM(h) <==> PPARgamma(h):RanBPM(h) (binding) | PPARgamma(h) --> CD36(h) (transactivation) | PPARgamma(h) --> FASLG(h) (DNA binding). | PPARgamma(h) --> NPHS1(h) (DNA binding). | PPARgamma(h) --> PRODH(h) (DNA binding). | PPARgamma(h) --> SIRT1(h) (transactivation) | PPARgamma(h) --> MYH11(r) (transactivation) | PPARG(h) --> PPARgamma(h) (expression). | PPARgamma(h) --> PPARgamma(h) (translocation) | Jagged1(h) --> PPARgamma(h) (increase of abundance) | PPARG(h) --> PPARgamma3(h) (expression). | PPARG(h) --> PPARgamma4(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
112 | Phosphoserine (by MAPK) (By similarity). | Swiss-Prot 53.0 | 112 | Phosphoserine (MAPK1;MAPK8) | 9030579 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr3 |
Promoter: 12303936 - 12305936 | Agilent_014791 |
chr3 |
Promoter: 12302849 - 12304849 | Agilent_014791 |
chr3 |
Promoter: 12302849 - 12304849 | GoldenGate_Methylation_Cancer_Panel_I |
chr3 |
Promoter: 12303936 - 12305936 | GoldenGate_Methylation_Cancer_Panel_I |
chr3 |
Promoter: 12302849 - 12304849 | GoldenGate_Methylation_Cancer_Panel_I |
chr3 |
Promoter: 12302849 - 12304849 | GSE27584 |
chr3 |
Promoter: 12303936 - 12305936 | GSE27584 |
chr3 |
Promoter: 12302849 - 12304849 | GSE27584 |
chr3 |
Promoter: 12302849 - 12304849 | Agilent_014791_44K |
chr3 |
Promoter: 12366501 - 12368501 | E-GEOD-20553 |