Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5580

Name

PRKCD

Synonymous

protein kinase C, delta;PRKCD;protein kinase C, delta

Definition

protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD

Position

3p21.31

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.17.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1705C>T; p.R569C; 3:53189208-53189208

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.637G>A; p.A213T; 3:53183186-53183186

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1658A>G; p.E553G; 3:53189161-53189161

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1657G>T; p.E553*; 3:53189160-53189160

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1658A>G; p.E553G; 3:53189161-53189161

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1451A>G; p.D484G; 3:53188755-53188755

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.100G>C; p.E34Q; 3:53178522-53178522

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.487G>A; p.A163T; 3:53181554-53181554

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.897C>T; p.S299S; 3:53185612-53185612

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.897C>T; p.S299S; 3:53185612-53185612

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1352+1G>A; p.?; 3:53186696-53186696

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmUnknown

c.897C>T; p.S299S; 3:53185612-53185612

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1352+1G>A; p.?; 3:53186696-53186696

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.1927C>T; p.R643C; 3:53192162-53192162

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1557_1558CC>TT; p.(=); 3:53189060-53189061

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.199C>T; p.R67C; 3:53179660-53179660

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1609C>T; p.L537F; 3:53189112-53189112

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.147G>A; p.P49P; 3:53179608-53179608

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.199C>T; p.R67C; 3:53179660-53179660

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1196G>A; p.R399Q; 3:53186276-53186276

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.905C>T; p.S302L; 3:53185620-53185620

 skinmalignant_melanomaSubstitution - Missense

c.280C>T; p.R94C; 3:53179741-53179741

 stomachcarcinomaSubstitution - Missense

c.603C>T; p.I201I; 3:53183152-53183152

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.681C>T; p.I227I; 3:53183475-53183475

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1573T>A; p.Y525N; 3:53189076-53189076

 breastcarcinomaSubstitution - Missense

c.1081G>A; p.G361R; 3:53186022-53186022

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.1080C>T; p.F360F; 3:53186021-53186021

 skinmalignant_melanomaSubstitution - coding silent

c.1755G>T; p.R585S; 3:53189884-53189884

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1809C>T; p.F603F; 3:53189938-53189938

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.17G>A; p.R6H; 3:53178439-53178439

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.21C>T; p.I7I; 3:53178443-53178443

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.17G>A; p.R6H; 3:53178439-53178439

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1728G>T; p.K576N; 3:53189231-53189231

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1608C>T; p.V536V; 3:53189111-53189111

 skinmalignant_melanomaSubstitution - coding silent

c.1525T>C; p.C509R; 3:53188829-53188829

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.132G>A; p.L44L; 3:53179593-53179593

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.2026G>T; p.D676Y; 3:53192261-53192261

 skinmalignant_melanomaSubstitution - Missense

c.1480A>G; p.M494V; 3:53188784-53188784

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.842G>A; p.G281D; 3:53184928-53184928

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.17G>T; p.R6L; 3:53178439-53178439

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.17G>T; p.R6L; 3:53178439-53178439

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.17G>T; p.R6L; 3:53178439-53178439

 large_intestine; coloncarcinomaSubstitution - Missense

c.1743+8C>T; p.?; 3:53189254-53189254

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.17G>T; p.R6L; 3:53178439-53178439

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.16C>T; p.R6C; 3:53178438-53178438

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1084A>T; p.K362*; 3:53186025-53186025

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Nonsense

c.735C>T; p.D245D; 3:53183529-53183529

 skinmalignant_melanomaSubstitution - coding silent

c.2010C>T; p.F670F; 3:53192245-53192245

 skinmalignant_melanomaSubstitution - coding silent

c.18C>T; p.R6R; 3:53178440-53178440

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.18C>T; p.R6R; 3:53178440-53178440

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2010C>T; p.F670F; 3:53192245-53192245

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.2010C>T; p.F670F; 3:53192245-53192245

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.689C>T; p.P230L; 3:53183483-53183483

 parathyroidadenomaSubstitution - Missense

c.520G>T; p.V174L; 3:53181587-53181587

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1383G>A; p.L461L; 3:53187370-53187370

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1383G>A; p.L461L; 3:53187370-53187370

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.315G>T; p.W105C; 3:53179776-53179776

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.74A>C; p.Q25P; 3:53178496-53178496

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1714A>C; p.T572P; 3:53189217-53189217

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1002C>T; p.Y334Y; 3:53185943-53185943

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.961G>A; p.G321R; 3:53185676-53185676

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1589A>G; p.D530G; 3:53189092-53189092

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.875A>G; p.N292S; 3:53184961-53184961

 peritoneum; appendixother; pseudomyxoma_peritoneiSubstitution - Missense

c.1119G>A; p.E373E; 3:53186199-53186199

 prostateadenomaSubstitution - coding silent

c.1119G>A; p.E373E; 3:53186199-53186199

 thyroidother; neoplasmSubstitution - coding silent

c.1349C>T; p.A450V; 3:53186692-53186692

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1558C>A; p.L520I; 3:53189061-53189061

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.201C>T; p.R67R; 3:53179662-53179662

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.199C>A; p.R67S; 3:53179660-53179660

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.219A>G; p.L73L; 3:53179680-53179680

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.636G>T; p.A212A; 3:53183185-53183185

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.104C>T; p.A35V; 3:53178526-53178526

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.104C>T; p.A35V; 3:53178526-53178526

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1198G>A; p.V400M; 3:53186278-53186278

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.145C>T; p.P49S; 3:53179606-53179606

 skinmalignant_melanomaSubstitution - Missense

c.1702C>G; p.P568A; 3:53189205-53189205

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1464G>T; p.K488N; 3:53188768-53188768

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.385C>T; p.Q129*; 3:53181452-53181452

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1581C>A; p.F527L; 3:53189084-53189084

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1680C>T; p.I560I; 3:53189183-53189183

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1821C>A; p.N607K; 3:53189950-53189950

 prostatecarcinomaSubstitution - Missense

c.1934C>T; p.S645F; 3:53192169-53192169

 skin; armmalignant_melanomaSubstitution - Missense

c.1197G>A; p.R399R; 3:53186277-53186277

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1298G>A; p.G433E; 3:53186641-53186641

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1469C>T; p.A490V; 3:53188773-53188773

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.350C>T; p.S117F; 3:53181241-53181241

 skinmalignant_melanomaSubstitution - Missense

c.646C>T; p.R216W; 3:53183195-53183195

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.877C>A; p.Q293K; 3:53184963-53184963

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1549C>T; p.P517S; 3:53188853-53188853

 skinmalignant_melanomaSubstitution - Missense

c.1331G>A; p.R444H; 3:53186674-53186674

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.83G>T; p.C28F; 3:53178505-53178505

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.609G>C; p.K203N; 3:53183158-53183158

 breastcarcinomaSubstitution - Missense

c.1438C>T; p.L480L; 3:53188742-53188742

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.865G>T; p.E289*; 3:53184951-53184951

 breastcarcinomaSubstitution - Nonsense

c.57C>T; p.A19A; 3:53178479-53178479

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1854A>C; p.P618P; 3:53189983-53189983

 breastcarcinomaSubstitution - coding silent

c.1083G>A; p.G361G; 3:53186024-53186024

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1294delG; p.D434fs*2; 3:53186637-53186637

 skinmalignant_melanomaDeletion - Frameshift

c.1294delG; p.D434fs*2; 3:53186637-53186637

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1294delG; p.D434fs*2; 3:53186637-53186637

 skinmalignant_melanomaDeletion - Frameshift

c.1294delG; p.D434fs*2; 3:53186637-53186637

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1906G>C; p.E636Q; 3:53192141-53192141

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1302C>T; p.D434D; 3:53186645-53186645

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.972G>A; p.G324G; 3:53185687-53185687

 skinmalignant_melanomaSubstitution - coding silent

c.825G>T; p.K275N; 3:53184911-53184911

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.355C>T; p.Q119*; 3:53181246-53181246

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1978T>C; p.F660L; 3:53192213-53192213

 skinmalignant_melanomaSubstitution - Missense

c.599G>A; p.C200Y; 3:53183148-53183148

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.73C>T; p.Q25*; 3:53178495-53178495

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.110G>A; p.S37N; 3:53178532-53178532

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.430C>T; p.R144C; 3:53181497-53181497

 skinmalignant_melanomaSubstitution - Missense

c.1503G>A; p.G501G; 3:53188807-53188807

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1702C>T; p.P568S; 3:53189205-53189205

 skinmalignant_melanomaSubstitution - Missense

c.1555-1G>C; p.?; 3:53189057-53189057

 breastcarcinomaUnknown

c.293A>C; p.N98T; 3:53179754-53179754

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.571C>T; p.Q191*; 3:53181732-53181732

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Nonsense

c.173C>T; p.T58M; 3:53179634-53179634

 pancreascarcinoid-endocrine_tumourSubstitution - Missense

c.436G>A; p.G146R; 3:53181503-53181503

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.173C>T; p.T58M; 3:53179634-53179634

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.277G>A; p.E93K; 3:53179738-53179738

 breastcarcinomaSubstitution - Missense

c.1090C>T; p.L364L; 3:53186170-53186170

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1707C>A; p.R569R; 3:53189210-53189210

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.705T>C; p.V235V; 3:53183499-53183499

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1443G>A; p.L481L; 3:53188747-53188747

 skinmalignant_melanomaSubstitution - coding silent

c.1631G>A; p.G544D; 3:53189134-53189134

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1692G>A; p.T564T; 3:53189195-53189195

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1213G>A; p.A405T; 3:53186293-53186293

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1576A>G; p.T526A; 3:53189079-53189079

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1491G>A; p.E497E; 3:53188795-53188795

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1293_1294insG; p.D434fs*13; 3:53186636-53186637

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

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