| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5601 |
Name | MAPK9 |
Synonymous | mitogen-activated protein kinase 9;MAPK9;mitogen-activated protein kinase 9 |
Definition | Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2 |
Position | 5q35 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.13. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.565C>T; p.R189W; 5:180249024-180249024 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.578C>T; p.A193V; 5:180249011-180249011 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.578C>T; p.A193V; 5:180249011-180249011 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.199G>A; p.A67T; 5:180269333-180269333 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.74G>A; p.R25H; 5:180280488-180280488 |
prostate | carcinoma | Substitution - Missense |
c.166A>G; p.K56E; 5:180269366-180269366 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.166A>G; p.K56E; 5:180269366-180269366 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1019C>T; p.A340V; 5:180239965-180239965 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.939C>T; p.D313D; 5:180241088-180241088 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.926G>A; p.R309Q; 5:180241101-180241101 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1086T>C; p.D362D; 5:180238378-180238378 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.831T>G; p.D277E; 5:180242613-180242613 |
stomach | carcinoma; diffuse_adenocarcinoma | Substitution - Missense |
c.104G>A; p.G35E; 5:180280458-180280458 |
liver | carcinoma | Substitution - Missense |
c.104G>A; p.G35E; 5:180280458-180280458 |
liver | carcinoma | Substitution - Missense |
c.104G>A; p.G35E; 5:180280458-180280458 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.822C>A; p.L274L; 5:180242622-180242622 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.292C>G; p.L98V; 5:180264800-180264800 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1043C>T; p.A348V; 5:180239941-180239941 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.947T>C; p.L316P; 5:180241080-180241080 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.312-6C>T; p.?; 5:180261828-180261828 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia | Unknown |
c.445C>A; p.H149N; 5:180261689-180261689 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.574C>T; p.R192W; 5:180249015-180249015 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.312-7C>T; p.?; 5:180261829-180261829 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia | Unknown |
c.856C>T; p.R286*; 5:180242588-180242588 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.829G>T; p.D277Y; 5:180242615-180242615 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.687C>T; p.D229D; 5:180247440-180247440 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.37G>A; p.V13M; 5:180280525-180280525 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.37G>A; p.V13M; 5:180280525-180280525 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1048G>T; p.E350*; 5:180239936-180239936 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.103G>A; p.G35R; 5:180280459-180280459 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.325G>A; p.E109K; 5:180261809-180261809 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.43G>C; p.V15L; 5:180280519-180280519 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.920A>G; p.D307G; 5:180241107-180241107 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.271G>A; p.V91M; 5:180264821-180264821 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.528G>A; p.A176A; 5:180249061-180249061 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.20A>G; p.D7G; 5:180280542-180280542 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.667G>A; p.V223M; 5:180247460-180247460 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.543G>A; p.M181I; 5:180249046-180249046 |
skin | malignant_melanoma | Substitution - Missense |
c.1078G>C; p.V360L; 5:180238386-180238386 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.189C>A; p.N63K; 5:180269343-180269343 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.679G>T; p.G227C; 5:180247448-180247448 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.679G>T; p.G227C; 5:180247448-180247448 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.679G>T; p.G227C; 5:180247448-180247448 |
large_intestine; colon | carcinoma | Substitution - Missense |
c.679G>T; p.G227C; 5:180247448-180247448 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.872-2A>T; p.?; 5:180241157-180241157 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Unknown |
c.826C>T; p.P276S; 5:180242618-180242618 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.527C>T; p.A176V; 5:180249062-180249062 |
central_nervous_system; brain | glioma | Substitution - Missense |
c.616G>A; p.V206I; 5:180248973-180248973 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.610G>A; p.E204K; 5:180248979-180248979 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.575G>A; p.R192Q; 5:180249014-180249014 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.128C>T; p.A43V; 5:180269404-180269404 |
skin; extremity | malignant_melanoma | Substitution - Missense |
c.807C>G; p.I269M; 5:180242637-180242637 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.744C>A; p.F248L; 5:180242700-180242700 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.997-2A>T; p.?; 5:180239989-180239989 |
liver | carcinoma; hepatocellular_carcinoma | Unknown |
c.681C>T; p.G227G; 5:180247446-180247446 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.799C>T; p.P267S; 5:180242645-180242645 |
skin | malignant_melanoma | Substitution - Missense |
c.662delG; p.G221fs*3; 5:180247465-180247465 |
lung | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.199delG; p.A67fs*11; 5:180269333-180269333 |
lung | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.273G>T; p.V91V; 5:180264819-180264819 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1123C>T; p.Q375*; 5:180238341-180238341 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.347G>A; p.C116Y; 5:180261787-180261787 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.199_200delGC; p.A67fs*6; 5:180269332-180269333 |
lung | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.363G>A; p.M121I; 5:180261771-180261771 |
skin | malignant_melanoma | Substitution - Missense |
c.907G>C; p.V303L; 5:180241120-180241120 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.214C>T; p.R72C; 5:180269318-180269318 |
skin | malignant_melanoma | Substitution - Missense |
c.311+3A>G; p.?; 5:180264778-180264778 |
liver | carcinoma | Unknown |
c.311+3A>G; p.?; 5:180264778-180264778 |
liver | carcinoma | Unknown |
c.949C>T; p.R317C; 5:180241078-180241078 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.168A>G; p.K56K; 5:180269364-180269364 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.596G>A; p.G199D; 5:180248993-180248993 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.1006C>T; p.Q336*; 5:180239978-180239978 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.103G>T; p.G35W; 5:180280459-180280459 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.752A>C; p.K251T; 5:180242692-180242692 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.34A>T; p.S12C; 5:180280528-180280528 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.954C>G; p.H318Q; 5:180241073-180241073 |
autonomic_ganglia | neuroblastoma | Substitution - Missense |
c.161T>A; p.V54D; 5:180269371-180269371 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.253-1G>A; p.?; 5:180264840-180264840 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |
c.167A>G; p.K56R; 5:180269365-180269365 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.168A>T; p.K56N; 5:180269364-180269364 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.168A>T; p.K56N; 5:180269364-180269364 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.167A>G; p.K56R; 5:180269365-180269365 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.925C>T; p.R309W; 5:180241102-180241102 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.857G>A; p.R286Q; 5:180242587-180242587 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.501C>T; p.I167I; 5:180249088-180249088 |
breast | carcinoma | Substitution - coding silent |