| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5601 |
Name | MAPK9 |
Synonymous | JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK;mitogen-activated protein kinase 9;MAPK9;mitogen-activated protein kinase 9 |
Definition | Jun kinase|MAP kinase 9|MAPK 9|c-Jun N-terminal kinase 2|c-Jun kinase 2|stress-activated protein kinase 1a|stress-activated protein kinase JNK2 |
Position | 5q35 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
JNK2(h) + ATP --MKK4(h)--> JNK2(h){p} + ADP (phosphorylation) | JNK2(h) + p53(m) <==> JNK2(h):p53(m) (binding) | JNK2(h) + NF-AT4(h) <==> JNK2(h):NF-AT4(h) (binding) | JNK2(h) + c-Jun(v.s.) <==> JNK2(h):c-Jun(v.s.) (binding) | JNK2(h) + ATF-2(v.s.) <==> JNK2(h):ATF-2(v.s.) (binding) | JNK2(h) + JIP1(m) <==> JNK2(h):JIP1(m) (binding) | MKK4beta(h) + JNK2(h) <==> MKK4beta(h):JNK2(h) (binding) | MKK7beta1(m) + JNK2(h) <==> MKK7beta1(m):JNK2(h) (binding) | MKP-7(v.s.) + JNK2(h) <==> MKP-7(v.s.):JNK2(h) (binding) | JNK2(h) + ATP --> JNK2(h){p} + ADP (phosphorylation) | JNK2(h) + 2 ATP --> JNK2(h){pT183}{pY185} + 2 ADP (phosphorylation) | JNK2(h) + ATP --> JNK2(h){pY} + ADP (phosphorylation) | JNK2(h) + KUP(h) <==> JNK2(h):KUP(h) (binding) | JNK2(h) + Sf3b-4(h) <==> JNK2(h):Sf3b-4(h) (binding) | JNK2(h) + kiaa1712(h) <==> JNK2(h):kiaa1712(h) (binding) | JNK2(h) + wdr62(h) <==> JNK2(h):wdr62(h) (binding) | JNK2(h){p} --MKP-5(h)--> JNK2(h) + p (dephosphorylation) | JNK2(h):NF-AT4(h) + ATP --> JNK2(h) + NF-AT4(h){p} + ADP (phosphorylation; dissociation) | MAPK9(h) --> JNK2(h) (expression). | c-Jun(v.s.) + ATP --JNK2(h)--> c-Jun(v.s.){p} + ADP (phosphorylation) | POU6F1(h) + ATP --JNK2(h)--> POU6F1(h){p} + ADP (phosphorylation) | RXR-alpha(m) + ATP --JNK2(h)--> RXR-alpha(m){pS265} + ADP (phosphorylation) | NR1B1(m) + ATP --JNK2(h)--> NR1B1(m){p} + ADP (phosphorylation) | c-Jun(m.s.) + ATP --JNK2(h)--> c-Jun(m.s.){p} + ADP (phosphorylation) | Elk-1(m.s.) + ATP --JNK2(h)--> Elk-1(m.s.){p} + ADP (phosphorylation) | ATF-2(m.s.) + ATP --JNK2(h)--> ATF-2(m.s.){p} + ADP (phosphorylation) | RRN3(h) + ATP --JNK2(h)--> RRN3(h){pT200} + ADP (phosphorylation) | c-Jun(m.s.) + 2 ATP --JNK2(h)--> c-Jun(m.s.){pS63}{pS73} + 2 ADP (phosphorylation) | JNK2alpha-2(h) + ATP --MKK4(m.s.)--> JNK2alpha-2(h){pY} + ADP (phosphorylation) | JNK2alpha-2(h) + 2 ATP --MKK7(h)--> JNK2alpha-2(h){pT404}{pS407} + 2 ADP (phosphorylation) | JNK2alpha-2(h) + 2 ATP --CKII(m.s.)--> JNK2alpha-2(h){pT404}{pS407} + 2 ADP (phosphorylation) | JNK2alpha-2(h) + ATP --> JNK2alpha-2(h) + ADP (phosphorylation; automodification) | MAPK9(h) --> JNK2alpha-2(h) (expression). | JNK2alpha-2(h) + ATP --> JNK2alpha-2(h) + ADP (phosphorylation; automodification) | Shc-1-p66(h) + ATP --JNK2alpha-2(h)--> Shc-1-p66(h){pS} + ADP (phosphorylation) | TAB1(h) + 2 ATP --JNK2alpha-2(h)--> TAB1(h){pT431}{pS438} + 2 ADP (phosphorylation) | c-Jun(h) + ATP --JNK2alpha-2(h)--> c-Jun(h){p} + ADP (phosphorylation) | ATF-2(h) + ATP --JNK2alpha-2(h)--> ATF-2(h){p} + ADP (phosphorylation) | MAPK9(h) --> JNK2beta-2(h) (expression). | JNK2alpha-1(h) + ATP --> JNK2alpha-1(h){p} + ADP (phosphorylation) | MAPK9(h) --> JNK2alpha-1(h) (expression). | MAPK9(h) --> JNK2beta-1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
183 | Phosphothreonine. | Swiss-Prot 53.0 | 185 | Phosphotyrosine. | Swiss-Prot 53.0 | 404 | Phosphothreonine (CK2 alpha;MA) | 11062067 | Phospho.ELM 6.0 | 407 | Phosphoserine (CK2 alpha;MA) | 11062067 | Phospho.ELM 6.0 | 183 | Phosphothreonine (MAP2K7) | 11062067;15755722 | Phospho.ELM 6.0 | 185 | Phosphotyrosine (MAP2K4) | 11062067;15755722 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr5 |
Promoter: 179639716 - 179641716 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 179639716 - 179641716 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 179639716 - 179641716 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 179639716 - 179641716 | GoldenGate_Methylation_Cancer_Panel_I |