Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6282

Name

S100A11

Synonymous

S100 calcium binding protein A11;S100A11;S100 calcium binding protein A11

Definition

MLN 70|S100 calcium-binding protein A11 (calgizzarin)|calgizzarin|epididymis secretory protein Li 43|metastatic lymph node gene 70 protein|protein S100-A11|protein S100-C

Position

1q21

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.169C>T; p.P57S; 1:152032811-152032811

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.23C>A; p.T8K; 1:152033781-152033781

 ovaryother; neoplasmSubstitution - Missense

c.113_114delAG; p.E38fs*23; 1:152033690-152033691

 oesophagus; lower_thirdcarcinoma; adenocarcinomaDeletion - Frameshift

c.231C>A; p.F77L; 1:152032749-152032749

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.230T>A; p.F77Y; 1:152032750-152032750

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.84T>C; p.D28D; 1:152033720-152033720

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.3+10A>G; p.?; 1:152036903-152036903

 prostatecarcinomaUnknown

c.74C>T; p.A25V; 1:152033730-152033730

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.211A>G; p.S71G; 1:152032769-152032769

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.35G>A; p.R12Q; 1:152033769-152033769

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.35G>A; p.R12Q; 1:152033769-152033769

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.261A>G; p.L87L; 1:152032719-152032719

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.261A>G; p.L87L; 1:152032719-152032719

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

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