| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 6678 |
Name | SPARC |
Synonymous | secreted protein, acidic, cysteine-rich (osteonectin);SPARC;secreted protein, acidic, cysteine-rich (osteonectin) |
Definition | BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine |
Position | 5q31.3-q32 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.06. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.816C>A; p.T272T; 5:151664154-151664154 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.750C>T; p.T250T; 5:151664220-151664220 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.131G>A; p.G44E; 5:151673206-151673206 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.54C>G; p.A18A; 5:151676135-151676135 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.54C>G; p.A18A; 5:151676135-151676135 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.637G>T; p.V213L; 5:151666458-151666458 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.787G>A; p.E263K; 5:151664183-151664183 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.829A>G; p.N277D; 5:151664141-151664141 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.503G>T; p.R168L; 5:151667549-151667549 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - Missense |
c.279C>T; p.C93C; 5:151671624-151671624 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.821A>C; p.D274A; 5:151664149-151664149 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.375C>G; p.F125L; 5:151669740-151669740 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.186C>T; p.T62T; 5:151673151-151673151 |
pituitary; craniopharyngeal_duct | craniopharyngioma; adamantinomatous | Substitution - coding silent |
c.652C>T; p.R218W; 5:151666443-151666443 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.661G>A; p.E221K; 5:151666434-151666434 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.844G>A; p.A282T; 5:151664126-151664126 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.844G>A; p.A282T; 5:151664126-151664126 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.844G>A; p.A282T; 5:151664126-151664126 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.844G>A; p.A282T; 5:151664126-151664126 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.679T>C; p.Y227H; 5:151666416-151666416 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.117T>A; p.T39T; 5:151674615-151674615 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.157G>T; p.G53*; 5:151673180-151673180 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.586-3C>T; p.?; 5:151666512-151666512 |
breast | carcinoma | Unknown |
c.705C>T; p.F235F; 5:151666390-151666390 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.595A>G; p.I199V; 5:151666500-151666500 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.663G>C; p.E221D; 5:151666432-151666432 |
skin | malignant_melanoma | Substitution - Missense |
c.150G>A; p.V50V; 5:151673187-151673187 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.310C>A; p.P104T; 5:151671593-151671593 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.187G>T; p.E63*; 5:151673150-151673150 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.280G>A; p.V94M; 5:151671623-151671623 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.23T>A; p.L8H; 5:151676166-151676166 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.23T>A; p.L8H; 5:151676166-151676166 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.393C>T; p.T131T; 5:151669722-151669722 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.380C>T; p.A127V; 5:151669735-151669735 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.491C>T; p.P164L; 5:151667561-151667561 |
skin | malignant_melanoma | Substitution - Missense |
c.407A>C; p.K136T; 5:151669708-151669708 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.122T>C; p.V41A; 5:151673215-151673215 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.250G>A; p.E84K; 5:151671653-151671653 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.250G>A; p.E84K; 5:151671653-151671653 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.250G>A; p.E84K; 5:151671653-151671653 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.626G>T; p.G209V; 5:151666469-151666469 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - Missense |
c.529A>T; p.T177S; 5:151667523-151667523 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.497G>A; p.R166H; 5:151667555-151667555 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.449A>G; p.K150R; 5:151669666-151669666 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.484G>C; p.E162Q; 5:151667568-151667568 |
skin | malignant_melanoma | Substitution - Missense |
c.840C>T; p.Y280Y; 5:151664130-151664130 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.454A>G; p.I152V; 5:151667598-151667598 |
bone; pelvis | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.636C>T; p.P212P; 5:151666459-151666459 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.538G>A; p.E180K; 5:151667514-151667514 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.730G>A; p.D244N; 5:151666365-151666365 |
breast | carcinoma | Substitution - Missense |
c.18C>A; p.F6L; 5:151676171-151676171 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.513C>T; p.L171L; 5:151667539-151667539 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma | Substitution - coding silent |
c.357C>T; p.F119F; 5:151669758-151669758 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.761C>A; p.P254Q; 5:151664209-151664209 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.732C>T; p.D244D; 5:151666363-151666363 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.550G>A; p.D184N; 5:151667502-151667502 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.694C>T; p.H232Y; 5:151666401-151666401 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.603G>T; p.E201D; 5:151666492-151666492 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.826G>T; p.D276Y; 5:151664144-151664144 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.860C>T; p.A287V; 5:151664110-151664110 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.860C>T; p.A287V; 5:151664110-151664110 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.513C>G; p.L171L; 5:151667539-151667539 |
breast | carcinoma | Substitution - coding silent |
c.352A>G; p.T118A; 5:151669763-151669763 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.576G>A; p.Q192Q; 5:151667476-151667476 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.261G>T; p.E87D; 5:151671642-151671642 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.160G>T; p.E54*; 5:151673177-151673177 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.358G>A; p.D120N; 5:151669757-151669757 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; mantle_cell_lymphoma | Substitution - Missense |
c.584G>A; p.R195Q; 5:151667468-151667468 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.335G>T; p.C112F; 5:151669780-151669780 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.749C>T; p.T250I; 5:151664221-151664221 |
skin | malignant_melanoma | Substitution - Missense |
c.469G>A; p.D157N; 5:151667583-151667583 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |