| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7704 |
Name | ZBTB16 |
Synonymous | zinc finger and BTB domain containing 16;ZBTB16;zinc finger and BTB domain containing 16 |
Definition | promyelocytic leukaemia zinc finger|zinc finger and BTB domain-containing protein 16|zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)|zinc finger protein PLZF |
Position | 11q23.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.00. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
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Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1412C>T; p.S471L; 11:114186997-114186997 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1274T>A; p.L425Q; 11:114156342-114156342 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1492C>T; p.R498C; 11:114242205-114242205 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1947G>A; p.M649I; 11:114250480-114250480 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.413C>T; p.A138V; 11:114063713-114063713 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.1528G>A; p.E510K; 11:114242241-114242241 |
skin; shoulder | malignant_melanoma | Substitution - Missense |