Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

84525

Name

HOPX

Synonymous

HOP homeobox;HOPX;HOP homeobox

Definition

homeodomain-only protein|lung cancer-associated Y protein|not expressed in choriocarcinoma clone 1|not expressed in choriocarcinoma protein 1|odd homeobox 1 protein|odd homeobox protein 1

Position

4q12

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.161G>A; p.R54H; 4:56648781-56648781

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.7G>A; p.A3T; 4:56655994-56655994

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.7G>A; p.A3T; 4:56655994-56655994

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.133G>A; p.E45K; 4:56655868-56655868

 skin; extremitymalignant_melanomaSubstitution - Missense

c.145-1G>T; p.?; 4:56648798-56648798

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.33G>A; p.E11E; 4:56655968-56655968

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.192G>T; p.L64L; 4:56648750-56648750

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.54G>C; p.E18D; 4:56655947-56655947

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.54G>C; p.E18D; 4:56655947-56655947

 livercarcinomaSubstitution - Missense

c.52G>A; p.E18K; 4:56655949-56655949

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.179G>A; p.R60H; 4:56648763-56648763

 livercarcinomaSubstitution - Missense

c.179G>A; p.R60H; 4:56648763-56648763

 livercarcinomaSubstitution - Missense

c.116A>T; p.E39V; 4:56655885-56655885

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.30A>C; p.T10T; 4:56655971-56655971

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.197C>T; p.S66L; 4:56648745-56648745

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.158A>T; p.Q53L; 4:56648784-56648784

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.93C>T; p.T31T; 4:56655908-56655908

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.115G>C; p.E39Q; 4:56655886-56655886

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.210C>T; p.S70S; 4:56648732-56648732

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.210C>T; p.S70S; 4:56648732-56648732

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.175C>T; p.R59W; 4:56648767-56648767

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.32A>T; p.E11V; 4:56655969-56655969

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.115G>A; p.E39K; 4:56655886-56655886

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.71T>C; p.V24A; 4:56655930-56655930

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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