| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 8453 |
Name | CUL2 |
Synonymous | cullin 2;CUL2;cullin 2 |
Definition | CUL-2|cullin-2 |
Position | 10p11.21 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.24. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.161G>C; p.G54A; 10:35063021-35063021 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.574G>C; p.E192Q; 10:35044801-35044801 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1348T>C; p.S450P; 10:35031338-35031338 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.891G>A; p.M297I; 10:35035283-35035283 |
skin; trunk | malignant_melanoma | Substitution - Missense |
c.1756_1758delCTT; p.L586delL; 10:35016321-35016323 |
endometrium | carcinoma; endometrioid_carcinoma | Deletion - In frame |
c.715-1G>A; p.?; 10:35039083-35039083 |
ovary | carcinoma; serous_carcinoma | Unknown |
c.128A>G; p.Y43C; 10:35063054-35063054 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1887G>T; p.K629N; 10:35016192-35016192 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1330A>T; p.I444F; 10:35031356-35031356 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.512G>T; p.R171L; 10:35044863-35044863 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.974G>A; p.R325Q; 10:35035200-35035200 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; mantle_cell_lymphoma | Substitution - Missense |
c.507-1G>T; p.?; 10:35044869-35044869 |
lung | carcinoma; adenocarcinoma | Unknown |
c.746G>A; p.R249Q; 10:35039051-35039051 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1101G>A; p.A367A; 10:35033175-35033175 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.805C>T; p.R269*; 10:35038992-35038992 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.1547C>T; p.A516V; 10:35028880-35028880 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1547C>T; p.A516V; 10:35028880-35028880 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.676T>G; p.L226V; 10:35044604-35044604 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1547C>T; p.A516V; 10:35028880-35028880 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.676T>G; p.L226V; 10:35044604-35044604 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1603A>T; p.K535*; 10:35028824-35028824 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.1732A>G; p.T578A; 10:35016347-35016347 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.218A>G; p.H73R; 10:35062964-35062964 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.2083C>T; p.R695W; 10:35011871-35011871 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.2083C>T; p.R695W; 10:35011871-35011871 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.904C>T; p.R302C; 10:35035270-35035270 |
skin | malignant_melanoma | Substitution - Missense |
c.1502T>C; p.I501T; 10:35029525-35029525 |
liver | carcinoma | Substitution - Missense |
c.1470C>G; p.F490L; 10:35029557-35029557 |
breast | carcinoma; lobular_carcinoma | Substitution - Missense |
c.317G>A; p.R106K; 10:35060874-35060874 |
skin | malignant_melanoma | Substitution - Missense |
c.551T>C; p.V184A; 10:35044824-35044824 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.300T>A; p.Y100*; 10:35060891-35060891 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.745C>T; p.R249*; 10:35039052-35039052 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.745C>T; p.R249*; 10:35039052-35039052 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.299A>G; p.Y100C; 10:35060892-35060892 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.49C>G; p.L17V; 10:35071269-35071269 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.745C>T; p.R249*; 10:35039052-35039052 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.745C>T; p.R249*; 10:35039052-35039052 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.513T>G; p.R171R; 10:35044862-35044862 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.2028G>A; p.R676R; 10:35011926-35011926 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1572A>T; p.S524S; 10:35028855-35028855 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2026C>T; p.R676W; 10:35011928-35011928 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.208C>T; p.R70W; 10:35062974-35062974 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1323delA; p.K441fs*3; 10:35031363-35031363 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.194_195insT; p.L65fs*10; 10:35062987-35062988 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.283A>T; p.S95C; 10:35060908-35060908 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1323delA; p.K441fs*3; 10:35031363-35031363 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1171C>T; p.L391F; 10:35031619-35031619 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.88G>A; p.V30I; 10:35071230-35071230 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.715-1G>T; p.?; 10:35039083-35039083 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |
c.1572A>G; p.S524S; 10:35028855-35028855 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.260A>G; p.Y87C; 10:35060931-35060931 |
ovary | other; neoplasm | Substitution - Missense |
c.260A>G; p.Y87C; 10:35060931-35060931 |
ovary | other; neoplasm | Substitution - Missense |
c.875delA; p.N292fs*20; 10:35038922-35038922 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.875delA; p.N292fs*20; 10:35038922-35038922 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1400A>T; p.Y467F; 10:35029627-35029627 |
breast | carcinoma | Substitution - Missense |
c.786G>A; p.V262V; 10:35039011-35039011 |
oesophagus | carcinoma | Substitution - coding silent |
c.1373T>G; p.I458S; 10:35031313-35031313 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.2232C>T; p.V744V; 10:35010317-35010317 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1850T>C; p.L617S; 10:35016229-35016229 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.2174T>A; p.L725Q; 10:35010375-35010375 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.2089A>T; p.N697Y; 10:35011865-35011865 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.945G>A; p.L315L; 10:35035229-35035229 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.523G>C; p.D175H; 10:35044852-35044852 |
ovary | other; neoplasm | Substitution - Missense |
c.739G>T; p.E247*; 10:35039058-35039058 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1774G>A; p.E592K; 10:35016305-35016305 |
liver | carcinoma | Substitution - Missense |
c.1774G>A; p.E592K; 10:35016305-35016305 |
liver | carcinoma | Substitution - Missense |
c.113G>A; p.R38H; 10:35071205-35071205 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.709G>T; p.E237*; 10:35044571-35044571 |
lung | carcinoma | Substitution - Nonsense |
c.1570T>C; p.S524P; 10:35028857-35028857 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1698G>T; p.M566I; 10:35016381-35016381 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1911G>A; p.S637S; 10:35013777-35013777 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1664G>T; p.W555L; 10:35025152-35025152 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1911G>A; p.S637S; 10:35013777-35013777 |
thyroid | other; neoplasm | Substitution - coding silent |
c.143C>T; p.A48V; 10:35063039-35063039 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.1547C>A; p.A516E; 10:35028880-35028880 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1348T>G; p.S450A; 10:35031338-35031338 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.363G>A; p.A121A; 10:35054494-35054494 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1325G>A; p.R442H; 10:35031361-35031361 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.957C>A; p.I319I; 10:35035217-35035217 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - coding silent |
c.1657C>A; p.L553I; 10:35025159-35025159 |
breast | carcinoma | Substitution - Missense |
c.905G>A; p.R302H; 10:35035269-35035269 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2056C>T; p.R686C; 10:35011898-35011898 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.2056C>T; p.R686C; 10:35011898-35011898 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.2056C>T; p.R686C; 10:35011898-35011898 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1910C>T; p.S637L; 10:35013778-35013778 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2194G>A; p.E732K; 10:35010355-35010355 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1305C>T; p.Y435Y; 10:35031381-35031381 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.99A>G; p.A33A; 10:35071219-35071219 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.1665G>A; p.W555*; 10:35025151-35025151 |
pancreas | carcinoma; ductal_carcinoma | Substitution - Nonsense |
c.1665G>A; p.W555*; 10:35025151-35025151 |
pancreas | carcinoma | Substitution - Nonsense |
c.1665G>A; p.W555*; 10:35025151-35025151 |
pancreas | pancreatic_intraepithelial_neoplasia_(PanIN) | Substitution - Nonsense |
c.2189A>G; p.Y730C; 10:35010360-35010360 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1387-2A>C; p.?; 10:35029642-35029642 |
ovary | other; neoplasm | Unknown |
c.2210C>T; p.S737L; 10:35010339-35010339 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.859C>T; p.R287*; 10:35038938-35038938 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.301A>G; p.M101V; 10:35060890-35060890 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.933G>A; p.M311I; 10:35035241-35035241 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1138G>C; p.E380Q; 10:35032467-35032467 |
prostate | carcinoma | Substitution - Missense |
c.266G>T; p.R89M; 10:35060925-35060925 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.604-10A>G; p.?; 10:35044686-35044686 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Unknown |
c.604-1G>A; p.?; 10:35044677-35044677 |
breast | carcinoma | Unknown |
c.2137C>T; p.P713S; 10:35010412-35010412 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.752G>A; p.R251Q; 10:35039045-35039045 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1371G>C; p.M457I; 10:35031315-35031315 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1206A>G; p.S402S; 10:35031584-35031584 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1561C>T; p.Q521*; 10:35028866-35028866 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.427G>A; p.A143T; 10:35049762-35049762 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.602A>C; p.K201T; 10:35044773-35044773 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.17G>A; p.R6K; 10:35071301-35071301 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.194delT; p.L65fs*54; 10:35062988-35062988 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.90C>T; p.V30V; 10:35071228-35071228 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.90C>T; p.V30V; 10:35071228-35071228 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.718C>T; p.L240L; 10:35039079-35039079 |
skin | malignant_melanoma | Substitution - coding silent |