Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8797

Name

TNFRSF10A

Synonymous

tumor necrosis factor receptor superfamily, member 10a;TNFRSF10A;tumor necrosis factor receptor superfamily, member 10a

Definition

TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor superfamily member 10a variant 2

Position

8p21

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.23T>C; p.V8A; 8:23225039-23225039

 oesophaguscarcinomaSubstitution - Missense

c.54G>C; p.P18P; 8:23225008-23225008

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1195G>A; p.A399T; 8:23191906-23191906

 skinmalignant_melanomaSubstitution - Missense

c.945G>A; p.M315I; 8:23199335-23199335

 skinmalignant_melanomaSubstitution - Missense

c.1263G>A; p.R421R; 8:23191838-23191838

 skinmalignant_melanomaSubstitution - coding silent

c.1122C>T; p.I374I; 8:23191979-23191979

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1122C>T; p.I374I; 8:23191979-23191979

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1262G>A; p.R421Q; 8:23191839-23191839

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1326_1327delGA; p.K443fs*>26; 8:23191774-23191775

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1170G>A; p.T390T; 8:23191931-23191931

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1170G>A; p.T390T; 8:23191931-23191931

 skinmalignant_melanomaSubstitution - coding silent

c.1170G>A; p.T390T; 8:23191931-23191931

 skinmalignant_melanomaSubstitution - coding silent

c.1170G>A; p.T390T; 8:23191931-23191931

 skinmalignant_melanomaSubstitution - coding silent

c.570C>G; p.C190W; 8:23201867-23201867

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.422A>G; p.H141R; 8:23202743-23202743

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.860G>A; p.R287Q; 8:23199420-23199420

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.860G>A; p.R287Q; 8:23199420-23199420

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.578G>A; p.G193E; 8:23201859-23201859

 skinmalignant_melanomaSubstitution - Missense

c.340C>T; p.H114Y; 8:23212179-23212179

 skinmalignant_melanomaSubstitution - Missense

c.594C>T; p.D198D; 8:23201843-23201843

 skinmalignant_melanomaSubstitution - coding silent

c.1122C>A; p.I374I; 8:23191979-23191979

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1122C>A; p.I374I; 8:23191979-23191979

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.309C>T; p.V103V; 8:23212210-23212210

 breastcarcinomaSubstitution - coding silent

c.1384G>A; p.G462S; 8:23191717-23191717

 skinmalignant_melanomaSubstitution - Missense

c.969G>T; p.L323F; 8:23199311-23199311

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.378C>T; p.S126S; 8:23212141-23212141

 skin; abdomenmalignant_melanomaSubstitution - coding silent

c.1327A>G; p.K443E; 8:23191774-23191774

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.681C>T; p.I227I; 8:23200709-23200709

 skinmalignant_melanomaSubstitution - coding silent

c.681C>T; p.I227I; 8:23200709-23200709

 skinmalignant_melanomaSubstitution - coding silent

c.682G>T; p.E228*; 8:23200708-23200708

 skinmalignant_melanomaSubstitution - Nonsense

c.464C>T; p.T155I; 8:23202701-23202701

 NSmalignant_melanomaSubstitution - Missense

c.440G>T; p.R147L; 8:23202725-23202725

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1218T>G; p.D406E; 8:23191883-23191883

 skinmalignant_melanomaSubstitution - Missense

c.1218T>G; p.D406E; 8:23191883-23191883

 skinmalignant_melanomaSubstitution - Missense

c.1035G>A; p.G345G; 8:23197184-23197184

 skinmalignant_melanomaSubstitution - coding silent

c.337C>T; p.L113F; 8:23212182-23212182

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.683A>C; p.E228A; 8:23200707-23200707

 skinmalignant_melanomaSubstitution - Missense

c.683A>C; p.E228A; 8:23200707-23200707

 skinmalignant_melanomaSubstitution - Missense

c.683A>C; p.E228A; 8:23200707-23200707

 thyroidother; neoplasmSubstitution - Missense

c.645G>T; p.M215I; 8:23200745-23200745

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.352A>G; p.I118V; 8:23212167-23212167

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1132G>A; p.D378N; 8:23191969-23191969

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.96C>T; p.A32A; 8:23224966-23224966

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.990C>T; p.S330S; 8:23199290-23199290

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1019C>T; p.P340L; 8:23197200-23197200

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.894G>C; p.E298D; 8:23199386-23199386

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.439C>A; p.R147R; 8:23202726-23202726

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1328A>G; p.K443R; 8:23191773-23191773

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1328A>G; p.K443R; 8:23191773-23191773

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.757C>T; p.L253L; 8:23200547-23200547

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.546G>A; p.T182T; 8:23201891-23201891

 skinmalignant_melanomaSubstitution - coding silent

c.1043G>A; p.R348K; 8:23197176-23197176

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.1185T>C; p.D395D; 8:23191916-23191916

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.751C>T; p.P251S; 8:23200553-23200553

 NSmalignant_melanomaSubstitution - Missense

c.845G>T; p.R282L; 8:23199435-23199435

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.874G>A; p.E292K; 8:23199406-23199406

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1369T>G; p.L457V; 8:23191732-23191732

 skinmalignant_melanomaSubstitution - Missense

c.947A>G; p.E316G; 8:23199333-23199333

 pancreascarcinomaSubstitution - Missense

c.799G>T; p.G267C; 8:23200505-23200505

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.440G>A; p.R147Q; 8:23202725-23202725

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.914C>T; p.S305L; 8:23199366-23199366

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.395G>T; p.C132F; 8:23212124-23212124

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.14C>T; p.P5L; 8:23225048-23225048

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.665C>T; p.T222M; 8:23200725-23200725

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.840C>G; p.F280L; 8:23199440-23199440

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.840C>G; p.F280L; 8:23199440-23199440

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.989C>T; p.S330F; 8:23199291-23199291

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1236G>A; p.L412L; 8:23191865-23191865

 skinmalignant_melanomaSubstitution - coding silent

c.95C>A; p.A32D; 8:23224967-23224967

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.844C>T; p.R282C; 8:23199436-23199436

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.425C>A; p.P142H; 8:23202740-23202740

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1215G>A; p.G405G; 8:23191886-23191886

 skinmalignant_melanomaSubstitution - coding silent

c.498A>G; p.P166P; 8:23202667-23202667

 stomachadenocarcinomaSubstitution - coding silent

c.1037C>G; p.S346C; 8:23197182-23197182

 oesophaguscarcinomaSubstitution - Missense

c.1177G>A; p.E393K; 8:23191924-23191924

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1177G>A; p.E393K; 8:23191924-23191924

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1083T>C; p.T361T; 8:23197136-23197136

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.626G>C; p.R209T; 8:23201811-23201811

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.626G>C; p.R209T; 8:23201811-23201811

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.626G>C; p.R209T; 8:23201811-23201811

 thyroidother; neoplasmSubstitution - Missense

c.1004A>G; p.Q335R; 8:23199276-23199276

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.580A>G; p.T194A; 8:23201857-23201857

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.862G>T; p.G288W; 8:23199418-23199418

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.753G>A; p.P251P; 8:23200551-23200551

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.709G>T; p.G237*; 8:23200595-23200595

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.801T>C; p.G267G; 8:23199916-23199916

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.385G>A; p.G129R; 8:23212134-23212134

 skinmalignant_melanomaSubstitution - Missense

c.295G>T; p.V99F; 8:23224767-23224767

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.187G>A; p.G63R; 8:23224875-23224875

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.933_934delTG; p.E312fs*32; 8:23199346-23199347

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.702A>G; p.S234S; 8:23200688-23200688

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

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