| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8797 |
Name | TNFRSF10A |
Synonymous | APO2|CD261|DR4|TRAILR-1|TRAILR1;tumor necrosis factor receptor superfamily, member 10a;TNFRSF10A;tumor necrosis factor receptor superfamily, member 10a |
Definition | TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor superfamily member 10a variant 2 |
Position | 8p21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Apo2L(h) + DR4(h) <==> Apo2L(h):DR4(h) (binding) | Apo2L(m) + DR4(h) <==> Apo2L(m):DR4(h) (binding) | DR4(h) + DR5(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> DR4(h):DR5(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | TNFRSF10A(h) --> DR4(h) (expression). | slc5a3(h) --> DR4(h) (increase of abundance) | DR4(h) + Apo2L(h) <==> DR4(h):Apo2L(h) (binding) | TNFRSF10A(h) --> DR4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
83 | Phosphoserine. | Swiss-Prot 53.0 | 156 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 463 | Phosphoserine. | Swiss-Prot 53.0 | 466 | Phosphoserine. | Swiss-Prot 53.0 | 83 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 461 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 463 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 466 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr8 |
Promoter: 23138084 - 23140084 | Agilent_014791 |
chr8 |
Promoter: 23138084 - 23140084 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 23138084 - 23140084 | GSE27584 |
chr8 |
Promoter: 23138084 - 23140084 | Agilent_014791_44K |
chr8 |
Promoter: 23138084 - 23140084 | PMID:15788647 |
chr8 |
Promoter: 23138084 - 23140084 | PMID:15316056 |