Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8841

Name

HDAC3

Synonymous

histone deacetylase 3;HDAC3;histone deacetylase 3

Definition

SMAP45

Position

5q31

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1168A>G; p.T390A; 5:141625257-141625257

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.314C>T; p.S105L; 5:141630093-141630093

 skinmalignant_melanomaSubstitution - Missense

c.292C>T; p.P98S; 5:141630115-141630115

 skinmalignant_melanomaSubstitution - Missense

c.109C>A; p.L37M; 5:141636577-141636577

 skinmalignant_melanomaSubstitution - Missense

c.820C>T; p.R274*; 5:141627903-141627903

 livercarcinoma; hepatocellular_carcinomaSubstitution - Nonsense

c.820C>T; p.R274*; 5:141627903-141627903

 skin; trunkmalignant_melanoma; nodularSubstitution - Nonsense

c.532C>T; p.Q178*; 5:141629251-141629251

 skinmalignant_melanomaSubstitution - Nonsense

c.926A>G; p.Y309C; 5:141626066-141626066

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.268G>A; p.V90I; 5:141634824-141634824

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.915C>G; p.R305R; 5:141626199-141626199

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.980-3A>T; p.?; 5:141625767-141625767

 livercarcinomaUnknown

c.980-3A>T; p.?; 5:141625767-141625767

 livercarcinoma; hepatocellular_carcinomaUnknown

c.980-3A>T; p.?; 5:141625767-141625767

 livercarcinomaUnknown

c.302T>C; p.F101S; 5:141630105-141630105

 skinmalignant_melanomaSubstitution - Missense

c.665C>T; p.P222L; 5:141628585-141628585

 skinmalignant_melanomaSubstitution - Missense

c.221G>A; p.S74N; 5:141634871-141634871

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.317G>A; p.R106H; 5:141630090-141630090

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.980-1G>T; p.?; 5:141625765-141625765

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.489G>A; p.R163R; 5:141629294-141629294

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.460A>G; p.I154V; 5:141629700-141629700

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1198_1199CC>TT; p.P400F; 5:141625226-141625227

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1041G>T; p.E347D; 5:141625703-141625703

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.884G>A; p.G295D; 5:141626230-141626230

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.178C>T; p.R60C; 5:141634914-141634914

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1012C>T; p.L338F; 5:141625732-141625732

 breastcarcinomaSubstitution - Missense

c.316C>T; p.R106C; 5:141630091-141630091

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.936G>A; p.S312S; 5:141626056-141626056

 livercarcinomaSubstitution - coding silent

c.155A>G; p.Q52R; 5:141634937-141634937

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.750G>A; p.T250T; 5:141628129-141628129

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.179G>A; p.R60H; 5:141634913-141634913

 pancreascarcinomaSubstitution - Missense

c.477-1G>T; p.?; 5:141629307-141629307

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.71T>C; p.M24T; 5:141636615-141636615

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.660C>T; p.N220N; 5:141628590-141628590

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.165A>G; p.Q55Q; 5:141634927-141634927

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.165A>G; p.Q55Q; 5:141634927-141634927

 thyroidother; neoplasmSubstitution - coding silent

c.132G>T; p.K44N; 5:141636554-141636554

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.902G>T; p.R301L; 5:141626212-141626212

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.315G>A; p.S105S; 5:141630092-141630092

 pancreascarcinomaSubstitution - coding silent

c.315G>A; p.S105S; 5:141630092-141630092

 pancreascarcinomaSubstitution - coding silent

c.315G>A; p.S105S; 5:141630092-141630092

 pancreascarcinomaSubstitution - coding silent

c.477-1G>A; p.?; 5:141629307-141629307

 skinmalignant_melanomaUnknown

c.277G>A; p.D93N; 5:141634815-141634815

 prostatecarcinomaSubstitution - Missense

c.139-10C>A; p.?; 5:141634963-141634963

 prostatecarcinoma; adenocarcinomaUnknown

c.420+1G>T; p.?; 5:141629859-141629859

 ovarycarcinoma; serous_carcinomaUnknown

c.189C>T; p.S63S; 5:141634903-141634903

 skinmalignant_melanomaSubstitution - coding silent

c.571T>C; p.S191P; 5:141629212-141629212

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.273C>T; p.G91G; 5:141634819-141634819

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.334C>T; p.L112L; 5:141630073-141630073

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.16G>A; p.A6T; 5:141636775-141636775

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.273C>T; p.G91G; 5:141634819-141634819

 stomachadenocarcinomaSubstitution - coding silent

c.328G>A; p.A110T; 5:141630079-141630079

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.328G>A; p.A110T; 5:141630079-141630079

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.313T>C; p.S105P; 5:141630094-141630094

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.949G>T; p.E317*; 5:141626043-141626043

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.793C>T; p.R265*; 5:141627930-141627930

 skinmalignant_melanomaSubstitution - Nonsense

c.793C>T; p.R265*; 5:141627930-141627930

 skin; trunkmalignant_melanoma; nodularSubstitution - Nonsense

c.202G>A; p.D68N; 5:141634890-141634890

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.998C>T; p.A333V; 5:141625746-141625746

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.476+10C>A; p.?; 5:141629674-141629674

 livercarcinomaUnknown

c.476+10C>A; p.?; 5:141629674-141629674

 livercarcinomaUnknown

c.1118C>T; p.P373L; 5:141625307-141625307

 skinmalignant_melanomaSubstitution - Missense

c.1261G>T; p.D421Y; 5:141621494-141621494

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.510C>T; p.D170D; 5:141629273-141629273

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.643C>T; p.R215C; 5:141628607-141628607

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.837C>T; p.C279C; 5:141626277-141626277

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.837C>T; p.C279C; 5:141626277-141626277

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.526G>C; p.G176R; 5:141629257-141629257

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.893A>T; p.Y298F; 5:141626221-141626221

 livercarcinomaSubstitution - Missense

c.295G>A; p.G99R; 5:141630112-141630112

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.295G>A; p.G99R; 5:141630112-141630112

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.988G>A; p.E330K; 5:141625756-141625756

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.567G>A; p.T189T; 5:141629216-141629216

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.685G>T; p.D229Y; 5:141628565-141628565

 thyroidother; neoplasmSubstitution - Missense

c.838G>A; p.V280I; 5:141626276-141626276

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.838G>A; p.V280I; 5:141626276-141626276

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1057C>T; p.Q353*; 5:141625687-141625687

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.188_189CC>AT; p.S63Y; 5:141634903-141634904

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1232A>G; p.N411S; 5:141621523-141621523

 breastcarcinomaSubstitution - Missense

c.332C>T; p.S111F; 5:141630075-141630075

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1098G>T; p.L366L; 5:141625327-141625327

 skinmalignant_melanomaSubstitution - coding silent

c.443A>G; p.N148S; 5:141629717-141629717

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1098G>T; p.L366L; 5:141625327-141625327

 skinmalignant_melanomaSubstitution - coding silent

c.1137C>T; p.D379D; 5:141625288-141625288

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.272G>A; p.G91D; 5:141634820-141634820

 skin; trunkmalignant_melanomaSubstitution - Missense

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