Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	8870
Name	IER3
Synonymous	immediate early response 3;IER3;immediate early response 3
Definition	PACAP-responsive gene 1 protein\|anti-death protein\|differentiation-dependent gene 2 protein\|expressed in pancreatic carcinoma\|gly96, mouse, homolog of\|immediate early protein GLY96\|immediate early response 3 protein\|immediately early gene X-1\|protein DIF-
Position	6p21.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.

The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.

The ratio of the loss-of-function mutations over missense mutations is 0.50.

The copy number variations for various cancers

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There is no record for IER3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.68C>T; p.T23I; 6:30744451-30744451	pancreas	carcinoma	Substitution - Missense
c.320C>G; p.A107G; 6:30744087-30744087	NS	NS	Substitution - Missense
c.259C>T; p.L87F; 6:30744148-30744148	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.194T>C; p.V65A; 6:30744325-30744325	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.168C>T; p.R56R; 6:30744351-30744351	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.275C>T; p.T92I; 6:30744132-30744132	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.9C>T; p.H3H; 6:30744510-30744510	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.127G>T; p.E43*; 6:30744392-30744392	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.156C>T; p.P52P; 6:30744363-30744363	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.240G>A; p.P80P; 6:30744167-30744167	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.240G>A; p.P80P; 6:30744167-30744167	central_nervous_system; brain	glioma	Substitution - coding silent

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