Entrez Gene

Basic Information
Gene ID	1027
Name	CDKN1B
Synonymous	CDKN4\|KIP1\|MEN1B\|MEN4\|P27KIP1;cyclin-dependent kinase inhibitor 1B (p27, Kip1);CDKN1B;cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Definition	cyclin-dependent kinase inhibitor 1B
Position	12p13.1-p12
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
cyclinE(h):Cdk2(h) + p27Kip1(h) <==> cyclinE(h):Cdk2(h):p27Kip1(h) (binding)
cyclinA(h):Cdk2(h) + p27Kip1(h) <==> cyclinA(h):Cdk2(h):p27Kip1(h) (binding)
Cdk4(h) + p27Kip1(h) <==> Cdk4(h):p27Kip1(h) (binding)
Cdk6(h) + p27Kip1(h) <==> Cdk6(h):p27Kip1(h) (binding)
cyclinE(h) + p27Kip1(h) <==> cyclinE(h):p27Kip1(h) (binding)
E2F-4(h):DP-1(h):p107(h):cyclinA(h):Cdk2(h) + p27Kip1(h) <==> E2F-4(h):DP-1(h):p107(h) + cyclinA(h):Cdk2(h):p27Kip1(h) (binding; dissociation)
AKT-1(h){pT308} + p27Kip1(h) <==> AKT-1(h){pT308}:p27Kip1(h) (binding)
AKT(h){pS473} + p27Kip1(h) <==> AKT(h){pS473}:p27Kip1(h) (binding)
p27Kip1(h) + 2 ATP --AKT-1(h){pT308}{pS473}--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation)
JAB1(h) + p27Kip1(h) <==> JAB1(h):p27Kip1(h) (binding)
p27Kip1(h) + Skp2(h) <==> p27Kip1(h):Skp2(h) (binding)
cyclinE1(h) + p27Kip1(h) <==> cyclinE1(h):p27Kip1(h) (binding)
Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding)
p27Kip1(h) + cyclinD1(h) + Cdk4(h) <==> p27Kip1(h):cyclinD1(h):Cdk4(h) (binding)
cyclinD1(h) + p27Kip1(h) <==> cyclinD1(h):p27Kip1(h) (binding)
Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding)
p27Kip1(h) --> protein remnants (degradation)
p27Kip1(h) + CUL4A(m.s.) <==> p27Kip1(h):CUL4A(m.s.) (binding)
p27Kip1(h) --> p27Kip1(h) (translocation)
p27Kip1(h) + cyclinD2(h) <==> p27Kip1(h):cyclinD2(h) (binding)
cyclinD3(h) + p27Kip1(h) <==> cyclinD3(h):p27Kip1(h) (binding)
p27Kip1(h) + TRAF2(h) <==> p27Kip1(h):TRAF2(h) (binding)
p27Kip1(h) + Pim(h) <==> p27Kip1(h):Pim(h) (binding)
p27Kip1(h) + pim1(h) <==> p27Kip1(h):pim1(h) (binding)
p27Kip1(h) + ATP --pim1(h)--> p27Kip1(h){p} + ADP (phosphorylation)
p27Kip1(h) + cyclinA(h) <==> p27Kip1(h):cyclinA(h) (binding)
p27Kip1(h) + ubiquitin(h) --> p27Kip1(h){ub} (ubiquitination)
Hsc70(h) + p27Kip1(h) <==> Hsc70(h):p27Kip1(h) (binding)
Histatin-3(h) + Hsc70-isoform1(h) + p27Kip1(h) <==> Histatin-3(h):Hsc70-isoform1(h):p27Kip1(h) (binding)
CDKN1B(h) --> p27Kip1(h) (expression).
E47(h) --> p27Kip1(h) (increase of abundance)
SIRT1(m) --> p27Kip1(h) (increase of abundance)
15d-PGJ2 --/ p27Kip1(h) (decrease of abundance)
DDB1(h) --/ p27Kip1(h) (decrease of abundance)
COPS1(h) --/ p27Kip1(h) (decrease of abundance)
DDB1(h) --> p27Kip1(h) (decrease of transport)
DDB1(m.s.) --/ p27Kip1(h) (decrease of abundance)
Skp2(h) --/ p27Kip1(h) (decrease of abundance)
ERK(h) --/ p27Kip1(h) (decrease of abundance)
FOXO3a(m.s.) --> p27Kip1(h) (increase of abundance)
p27Kip1(h) --> p27Kip1(h) (translocation)
TGFbeta1(h) --> p27Kip1(h) (increase of abundance)
Cdx-2(h) --/ p27Kip1(h) (decrease of abundance)
s100a11(h) --/ p27Kip1(h) (decrease of abundance)
Skp2(m.s.) --/ p27Kip1(h) (decrease of abundance)
EGF(m.s.) --/ p27Kip1(h) (decrease of abundance)
AKT-1(h) --/ p27Kip1(h) (decrease of abundance)
Fzr(h) --> p27Kip1(h) (increase of abundance)
p27Kip1(h) + Cdk4(h) <==> p27Kip1(h):Cdk4(h) (binding)
p27Kip1(h) + cyclinE(h) + Cdk2(h) <==> p27Kip1(h):cyclinE(h):Cdk2(h) (binding)
p27Kip1(h) + cyclinD1(h) <==> p27Kip1(h):cyclinD1(h) (binding)
p27Kip1(h) + 2 ATP --pim1(h)--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation)
p27Kip1(h) + 14-3-3(h) <==> p27Kip1(h):14-3-3(h) (binding)
p27Kip1(h) + 14-3-3beta(h) <==> p27Kip1(h):14-3-3beta(h) (binding)
p27Kip1(h) + 14-3-3eta(h) <==> p27Kip1(h):14-3-3eta(h) (binding)
p27Kip1(h) + 14-3-3sigma(h) <==> p27Kip1(h):14-3-3sigma(h) (binding)
p27Kip1(h) + 14-3-3zeta(h) <==> p27Kip1(h):14-3-3zeta(h) (binding)
p27Kip1(h) + 14-3-3gamma(h) <==> p27Kip1(h):14-3-3gamma(h) (binding)
p27Kip1(h) + 14-3-3tau(h) <==> p27Kip1(h):14-3-3tau(h) (binding)
p27Kip1(h) + n ubiquitin(h) --ATP,KPC1-isoform1(h),Ubc5A(h),E1(h)--> p27Kip1(h){ub(n)} (ubiquitination)
CDKN1B(h) --> p27Kip1(h) (expression).
p27Kip1(h){p} --Cdc14A(h)--> p27Kip1(h) + p (dephosphorylation)
pim1(h) --/ p27Kip1(h) (decrease of abundance)
CDKN1B(h) --> CDKN1B(h) (expression).
hsa-miR-221 --/ CDKN1B(h) (increase of mRNA decay).
hsa-miR-222 --/ CDKN1B(h) (increase of mRNA decay).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
10	Phosphoserine (by UHMK1).		Swiss-Prot 53.0
10	Phosphoserine (KIS;CDK2)	15302935;12093740;12042314;15735731;14504289;12482	Phospho.ELM 6.0
187	Phosphothreonine (MAPK1;CDK2)	10831586;12700233;12042314;15735731	Phospho.ELM 6.0
178	Phosphoserine (MAPK1)	10831586	Phospho.ELM 6.0
83	Phosphoserine (CK2 alpha)	15034923	Phospho.ELM 6.0
89	Phosphotyrosine	16195327	Phospho.ELM 6.0
88	Phosphotyrosine	16195327	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr12	Promoter: 12760076 - 12762076	Agilent_014791
chr12	Promoter: 12760076 - 12762076	GoldenGate_Methylation_Cancer_Panel_I
chr12	Promoter: 12760076 - 12762076	GSE27584
chr12	Promoter: 12760076 - 12762076	PMID:12149142
chr12	Promoter: 12760076 - 12762076	PMID:11943705
chr12	Promoter: 12760076 - 12762076	PMID:11042700
chr12	Promoter: 12760076 - 12762076	PMID:11522621
chr12	Promoter: 12760076 - 12762076	PMID:15975525
chr12	Promoter: 12760076 - 12762076	PMID:15695118

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]