| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 23586 |
Name | DDX58 |
Synonymous | RIG-I|RIGI|RLR-1|SGMRT2;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58;DDX58;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
Definition | DEAD box protein 58|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RNA helicase RIG-I|probable ATP-dependent RNA helicase DDX58|retinoic acid-inducible gene 1 protein|retinoic acid-inducible gene I protein |
Position | 9p12 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
There is no record for DDX58 | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
MAVS(h) + ddx58(h) <==> MAVS(h):ddx58(h) (binding) | IRF-3(m.s.) + ddx58(h) + MAVS(h) <==> IRF-3(m.s.):ddx58(h):MAVS(h) (binding) | ddx58(h) --> IFNB1(h) (transactivation) | ddx58(h) --> IFNbeta(h) (increase of abundance) | ddx58(h) --> IRF-3(m.s.){pS396} (increase of phosphorylation) | ddx58(h) --> (IRF-3(h))2 (increase of oligomerization) | DDX58(h) --> ddx58(h) (expression). | RNF125(h) + ddx58(h) <==> RNF125(h):ddx58(h) (binding) | MAVS(h) + ddx58(h) <==> MAVS(h):ddx58(h) (binding) | n ddx58(h) <==> (ddx58(h))n (binding; oligomerization) | ddx58(h) --> ddx58(h) (expression). | IFNalpha2(m.s.) --> ddx58(h) (increase of abundance) | HCV-NS3-1A(HCV1A):HCV-NS4A-1A(HCV1A) --/ ddx58(h) (decrease of abundance) | IFNalpha(m.s.) --> ddx58(h) (increase of abundance) |
|---|
Post Transcriptional Modification [Top] | |||
There is no record for DDX58 | |||
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 32515822 - 32517822 | Agilent_014791 |
chr9 |
Promoter: 32515822 - 32517822 | GSE27584 |
chr9 |
Promoter: 32515822 - 32517822 | Agilent_014791_44K |