| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 23586 |
Name | DDX58 |
Synonymous | RIG-I|RIGI|RLR-1|SGMRT2;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58;DDX58;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
Definition | DEAD box protein 58|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RNA helicase RIG-I|probable ATP-dependent RNA helicase DDX58|retinoic acid-inducible gene 1 protein|retinoic acid-inducible gene I protein |
Position | 9p12 |
Gene type | protein-coding |
|
Title |
Abstract |
| Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. | In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-alpha (IFN-alpha) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-alpha therapy, suggesting that RIG-I is a useful prognosis and IFN-alpha response predictor for HCC patients. Mechanistically, RIG-I enhances IFN-alpha response by amplifying IFN-alpha effector signaling via strengthening STAT1 activation. Furthermore, we found that RIG-I deficiency promotes HCC carcinogenesis and that hepatic RIG-I expression is lower in men than in women. RIG-I may therefore be a tumor suppressor in HCC and contribute to HCC gender disparity. |