| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3479 |
Name | IGF1 |
Synonymous | IGF-I|IGF1A|IGFI;insulin-like growth factor 1 (somatomedin C);IGF1;insulin-like growth factor 1 (somatomedin C) |
Definition | IGF-IA|IGF-IB|MGF|insulin-like growth factor I|insulin-like growth factor IA|insulin-like growth factor IB|mechano growth factor|somatomedin-C |
Position | 12q23.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
IGF-1A(h) --> PDK1(h){pS241}{pY373}{pY376} (increase of phosphorylation) | IGF-1A(h) --> AKT-1(h){pT308} (increase of phosphorylation) | IGF-1A(h) --> PKCzeta(h){pT410} (increase of phosphorylation) | IGF1(h) --> IGF-1A(h) (expression). | IGF1(h) --> IGF-1B(h) (expression). | IGF-1(h) --> IRS-1(ha){pY} (increase of phosphorylation) | IGF-1(h) --> ERK(r){p} (increase of phosphorylation) | IGF-1(h) --> AKT-1(r){pS473} (increase of phosphorylation) | IGF-1(h) --> p70S6K(r){pT389} (increase of phosphorylation) | IGF-1(h) --> bad(r){pS112}{pS136} (increase of phosphorylation) | IGF-1(h) --> FKHR(r){pS256} (increase of phosphorylation) | IGF-1(h) --> GSK3beta(r){pS9} (increase of phosphorylation) | IGF-1(h) --> CREB1(r){p} (increase of phosphorylation) | IGF-1(h) --> IRS-1(ha){pY608}{pY895}{pY1172} (increase of phosphorylation) | IGF-1(h) --> ERK2(m){p} (increase of phosphorylation) | IGF-1(h) --> IRS-1(m){pY} (increase of phosphorylation) | IGF-1(h) --> p85(m):IRS-1(m){pY} (increase of binding) | IGF-1(h) --> IRS-1(h){pY} (increase of phosphorylation) | IGF-1(h) --> IRS-1(h){pY}:p85(h) (increase of binding) | IGF-1(h) --> AKT(h){p} (increase of phosphorylation) | IGF-1(h) --> ERK1(h){p} (increase of phosphorylation) | IGF-1(h) --> ERK2(h){p} (increase of phosphorylation) | IGF-1(h) --> paxillin(h){pY} (increase of phosphorylation) | IGF-1(h) --> FAK1(h){pY} (increase of phosphorylation) | IGF-1(h) --> beta1-integrin(h):FAK1(h){pY} (increase of binding) | IGF-1(h) --> beta1-integrin(h):paxillin(h){pY} (increase of binding) | IGF-1(h) --> beta1-integrin(h):alpha-actinin(h) (increase of binding) | IGF-1R(h) + IGF-1(h) <==> IGF-1R(h):IGF-1(h) (binding) | IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding) | IGF-1(h) --> AKT(r){pT308}{pS473} (increase of phosphorylation) | IGF-1(h) --> RSK(r){p} (increase of phosphorylation) | IGF-1(h) --> GSK3beta(r){p} (increase of phosphorylation) | IGF-1(h) --> FOXG1(r){pS} (increase of phosphorylation) | IGF-1(h) --> FOXO3a(r){pT32} (increase of phosphorylation) | IGF-1(h) --> AKT(m){p} (increase of phosphorylation) | IGF-1(h) --> FOXO3a(m){pT32} (increase of phosphorylation) | IGF-1(h) + IBP-1(h) <==> IGF-1(h):IBP-1(h) (binding) | IGF-1(h) + IGFBP-2(h) <==> IGF-1(h):IGFBP-2(h) (binding) | IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding) | IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding) | IGF-1(h) + IGFBP-5(h) <==> IGF-1(h):IGFBP-5(h) (binding) | IGF-1(h) + IGFBP-6(h) <==> IGF-1(h):IGFBP-6(h) (binding) | IGF-1(h) + IGFBP-2(h) <==> IGF-1(h):IGFBP-2(h) (binding) | IGF-1(h) + IGFBP-2(b) <==> IGF-1(h):IGFBP-2(b) (binding) | IGF-1(h) + IGFBP-2(b) <==> IGF-1(h):IGFBP-2(b) (binding) | IGF-1(h) + IGFBP-3(b) <==> IGF-1(h):IGFBP-3(b) (binding) | IGF-1(h) + IGFBP-4(h) <==> IGF-1(h):IGFBP-4(h) (binding) | IGF-1(h) + IGFBP-5(h) <==> IGF-1(h):IGFBP-5(h) (binding) | IGF-1(h) + IGFBP-4(r) <==> IGF-1(h):IGFBP-4(r) (binding) | IGF-1(h) --> p70S6K1-alpha2(h){pT389} (increase of phosphorylation) | IGF-1(h) --> FOXO3a(r){pT32}{pS253} (increase of phosphorylation) | IGF-1(h) --> MEK(r){p} (increase of phosphorylation) | IGF-1(h) --> ERK1(r){p} (increase of phosphorylation) | IGF-1(h) --> ERK2(r){p} (increase of phosphorylation) | IGF-1(h) --> IRS-1(r){pY} (increase of phosphorylation) | IGF-1(h) --> IRS-1(r){pY}:p85(r) (increase of binding) | IGF-1(h) --> p85(pg):Grb-2(pg) (increase of binding) | IGF-1(h) --> p85(pg):SHPS1(pg) (increase of binding) | IGF-1(h) --> AKT-1(pg){pS473}{pT308} (increase of phosphorylation) | IGF-1(h) --> p85alpha(h):Grb-2(pg) (increase of binding) | IGF-1(h) --> p85alpha(h):SHPS1(pg) (increase of binding) | IGF-1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | IGF-1(h) --> Mcl-1(r) (increase of abundance) | IGF-1(h) --> AKT-1(m){pS473} (increase of phosphorylation) | IGF-1(h) --> ERK1(m){pT203}{pY205} (increase of phosphorylation) | IGF-1(h) --> ERK2(m){pT183}{pY185} (increase of phosphorylation) | IGF-1(h) --> AKT-1(h){pT308}{pS473} (increase of phosphorylation) | IGF-1(h) --> p70S6K1(h){pT389} (increase of phosphorylation) | IGF-1(h) --> Skp2(h) (increase of abundance) | IGF-1(h) --> CYP19A1(b) (transactivation) | IGF-1(h) --> FSHR(b) (transactivation) | IGF-1(h) --> Grb-2(pg):Shc-1(pg) (increase of binding) | IGF-1(h) --> Grb-2(pg):Shc-1-p66(h) (increase of binding) | IGF-1(h) --> SHPS1(pg):Shc-1(pg) (increase of binding) | IGF-1(h) --> Shc-1-p66(h):SHPS1(pg) (increase of binding) | IGF-1(h) --> SHPS1(pg){pY99} (increase of phosphorylation) | IGF-1(h) --> Src(pg):Shc-1-p66(h) (increase of binding) | IGF-1(h) --> Src(pg):Shc-1(pg) (increase of binding) | IGF-1(h) --> Shc-1(pg){pY} (increase of phosphorylation) | IGF-1(h) --> ERK1(pg){pT}{pY} (increase of phosphorylation) | IGF-1(h) --> ERK2(pg){pT}{pY} (increase of phosphorylation) | IGF1(h) --> IGF-1(h) (expression). | catalase(m.s.) --> IGF-1(h) (activation) | 5alphaDHT --> IGF-1(h) (increase of abundance) | testosterone --> IGF-1(h) (increase of abundance) | GH(m.s.) --> IGF-1(h) (increase of abundance) | SHP-2(h) --/ IGF-1(h) (decrease of abundance) | PTP1B(h) --/ IGF-1(h) (decrease of abundance) | CHIP(h) --/ IGF-1(h) (decrease of abundance) | SRC3(h) --> IGF-1(h) (increase of abundance) |
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Post Transcriptional Modification [Top] | |||
There is no record for IGF1 | |||
Methylation Profile [Top] | ||
There is no record for IGF1 | ||