Entrez Gene

Basic Information
Gene ID	5494
Name	PPM1A
Synonymous	PP2C-ALPHA\|PP2CA\|PP2Calpha;protein phosphatase, Mg2+/Mn2+ dependent, 1A;PPM1A;protein phosphatase, Mg2+/Mn2+ dependent, 1A
Definition	protein phosphatase 1A\|protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Position	14q23.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
PPM1A(h) --> PP2Calpha1(h) (expression).
Cdk2(h){pT160} --PP2Calpha1(h)--> Cdk2(h) + p (dephosphorylation)
Cdk6(h){pT177} --PP2Calpha1(h)--> Cdk6(h) + p (dephosphorylation)
PP2Calpha2(h) + p38(h){p} <==> PP2Calpha2(h):p38(h){p} (binding)
PPM1A(h) --> PP2Calpha2(h) (expression).
MKK6(h){p} --PP2Calpha2(h)--> MKK6(h) + p (dephosphorylation)
MKK4(h){p} --PP2Calpha2(h)--> MKK4(h) + p (dephosphorylation)
p38(h){p} --PP2Calpha2(h)--> p38(h) + p (dephosphorylation)
ECI(h) + PP2Calpha(h) <==> ECI(h):PP2Calpha(h) (binding)
PPM1A(h) --> PP2Calpha(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
377	Phosphoserine (By similarity).		Swiss-Prot 53.0