Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5933

Name

RBL1

Synonymous

CP107|PRB1|p107;retinoblastoma-like 1;RBL1;retinoblastoma-like 1

Definition

107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like 1 (p107)|retinoblastoma-like protein 1

Position

20q11.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

p107(h) + cyclinA(h):Cdk2(h) <==> p107(h):cyclinA(h):Cdk2(h) (binding)
p107(h) + cyclinE(h):Cdk2(h) <==> p107(h):cyclinE(h):Cdk2(h) (binding)
E1A(12S)(AD12) + p107(h) + p130(h) + pRb(h) + p300(h) <==> E1A(12S)(AD12):p300(h):pRb(h):p130(h):p107(h) (binding)
p107(h) --> DHFR(ha) (DNA binding).
DP-2(h) + p107(h) <==> DP-2(h):p107(h) (binding)
DP-1(h) + p107(h) <==> DP-1(h):p107(h) (binding)
E2F-5(h):DP-1(h) + p107(h) <==> E2F-5(h):DP-1(h):p107(h) (binding)
E2F-4(h) + p107(h) <==> E2F-4(h):p107(h) (binding)
E2F-4(h):DP-1(h) + p107(h) <==> E2F-4(h):DP-1(h):p107(h) (binding)
p107(h) + p202(m) <==> p107(h):p202(m) (binding)
c-Myc(h) + p107(h) <==> c-Myc(h):p107(h) (binding).
p107(h) + T-Ag(SV) <==> p107(h):T-Ag(SV) (binding).
E2F-5(h) + p107(h) <==> E2F-5(h):p107(h) (binding).
Sp1(h) + p107(h) <==> Sp1(h):p107(h) (binding).
E2F(h):DP(h) + p107(h) <==> E2F(h):DP(h):p107(h) (binding).
cyclinA(h) + p107(h) <==> cyclinA(h):p107(h) (binding).
E1A 13S protein(AD2) + p107(h) <==> E1A 13S protein(AD2):p107(h) (binding).
p107(h) + E1A(AD) <==> p107(h):E1A(AD) (binding)
p107(h) + RBBP1(h) <==> p107(h):RBBP1(h) (binding)
HDAC1(h) + p107(h) <==> HDAC1(h):p107(h) (binding)
p107(h) + hdac2(h) <==> p107(h):hdac2(h) (binding)
p107(h) + HDAC3(h) <==> p107(h):HDAC3(h) (binding)
CtIP(h) + p107(h) <==> CtIP(h):p107(h) (binding)
p107(h) + begain(h) <==> p107(h):begain(h) (binding)
p107(h) --> Abcc10(h) (DNA binding).
p107(h) + Cdk2(h) <==> p107(h):Cdk2(h) (binding)
RBL1(h) --> p107(h) (expression).
HCV-NS5B-1B-Japanese(HCV1BJapan) --> p107(h) (increase of abundance)
RBL1(h) --> p107-xbb1(h) (expression).
RBL1(h) --> p107-isoform1(h) (expression).
RBL1(h) --> p107-isoform2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

332Phosphothreonine (by CDK2).Swiss-Prot 53.0
369Phosphothreonine (by CDK4).Swiss-Prot 53.0
385Phosphothreonine (by CDK2).Swiss-Prot 53.0
640Phosphoserine (by CDK2 and CDK4).Swiss-Prot 53.0
650Phosphoserine.Swiss-Prot 53.0
762Phosphoserine (by CDK2).Swiss-Prot 53.0
964Phosphoserine (by CDK2 and CDK4).Swiss-Prot 53.0
975Phosphoserine (by CDK2 and CDK4).Swiss-Prot 53.0
988Phosphoserine (by CDK2).Swiss-Prot 53.0
997Phosphothreonine (by CDK2).Swiss-Prot 53.0
1009Phosphoserine (by CDK2).Swiss-Prot 53.0
369Phosphothreonine (CDK4)12006580Phospho.ELM 6.0
340Phosphothreonine12006580Phospho.ELM 6.0
332Phosphothreonine12006580Phospho.ELM 6.0
997Phosphothreonine12006580Phospho.ELM 6.0
762Phosphoserine12006580Phospho.ELM 6.0
749Phosphoserine12006580Phospho.ELM 6.0
650Phosphoserine (CDK4)12006580Phospho.ELM 6.0
640Phosphoserine (CDK4)12006580;11884610Phospho.ELM 6.0
615Phosphoserine12006580Phospho.ELM 6.0
1041Phosphoserine12006580Phospho.ELM 6.0
1009Phosphoserine12006580Phospho.ELM 6.0
988Phosphoserine12006580Phospho.ELM 6.0
975Phosphoserine (CDK4)12006580;11884610;10069453Phospho.ELM 6.0
964Phosphoserine (CDK4)12006580Phospho.ELM 6.0
385Phosphothreonine12006580Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr20

Promoter: 35157324 - 35159324Agilent_014791

chr20

Promoter: 35157324 - 35159324GSE27584

chr20

Promoter: 35157324 - 35159324GSE27584

chr20

Promoter: 35157324 - 35159324Agilent_014791_44K


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