| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7128 |
Name | TNFAIP3 |
Synonymous | A20|OTUD7C|TNFA1P2;tumor necrosis factor, alpha-induced protein 3;TNFAIP3;tumor necrosis factor, alpha-induced protein 3 |
Definition | OTU domain-containing protein 7C|TNF alpha-induced protein 3|putative DNA-binding protein A20|tumor necrosis factor alpha-induced protein 3|tumor necrosis factor inducible protein A20|zinc finger protein A20 |
Position | 6q23 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
A20(h) + IKK-gamma(h) <==> A20(h):IKK-gamma(h) (binding) | A20(h) + TRAF1(m) + TRAF2(m) <==> A20(h):TRAF1(m):TRAF2(m) (binding) | TNFR1(h) + A20(h) <==> TNFR1(h):A20(h) (binding) | TNFR1(h) + RIP(h) + A20(h) + IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 <==> TNFR1(h):RIP(h):IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2:A20(h) (binding) | A20(h) + 14-3-3beta(h) <==> A20(h):14-3-3beta(h) (binding) | A20(h) + 14-3-3zeta(h) <==> A20(h):14-3-3zeta(h) (binding) | A20(h) + 14-3-3eta(h) <==> A20(h):14-3-3eta(h) (binding) | A20(h) + 14-3-3gamma(h) <==> A20(h):14-3-3gamma(h) (binding) | A20(h) + 14-3-3epsilon(h) <==> A20(h):14-3-3epsilon(h) (binding) | A20(h) + 14-3-3(h) + Raf-1(h) <==> A20(h):14-3-3(h):Raf-1(h) (binding) | A20(h) + ATP --IKK-beta(h)--> A20(h){pS381} + ADP (phosphorylation) | A20(h) --> A20-p37(h) + protein remnants (cleavage) | A20(h) + MALT1(h):bcl10(h) <==> A20(h):MALT1(h):bcl10(h) (binding) | A20(h) --> IL-2(h) (decrease of secretion) | A20(h) --> A20-p50(h) + A20-p37(h) (cleavage) | A20(h) --> JNK(h){pT}{pY} (decrease of phosphorylation) | A20(h) --> IkappaB-alpha(h){pS32} (decrease of phosphorylation) | RIP(h) + A20(h) <==> RIP(h):A20(h) (binding) | TNFAIP3(h) --> A20(h) (expression). | TICAM(m.s.) + A20(h) <==> TICAM(m.s.):A20(h) (binding) | A20(h) + n ubiquitin(h) --> A20(h){ub}n (ubiquitination) | A20(h) + n ubiquitin(h) --> A20(h){ub{K48}(n)} (ubiquitination; automodification) | A20(h) + RIP(h) <==> A20(h):RIP(h) (binding) | A20(h) --> RIP(h){ub{K63}(n)} (decrease of ubiquitination) | A20(h) --> RIP(m.s.){ub{K63}(n)} (decrease of ubiquitination) | A20(h) --> RIP(m.s.){ub{K48}(n)} (increase of ubiquitination) | A20(h) + TRAF6(m) <==> A20(h):TRAF6(m) (binding) | A20(h) --/ TNFAIP3(h) (transrepression) | A20(h) --> A20-p37(h) + A20-p50(h) (cleavage) | A20(h) --> A20-p50(h) + protein remnants (cleavage) | A20(h) --/ TRAF2-isoform1(m) (decrease of abundance) | RIP(m.s.) + A20(h) <==> RIP(m.s.):A20(h) (binding) | A20(h) + TRAF6(m.s.) <==> A20(h):TRAF6(m.s.) (binding) | TNFAIP3(h) --> A20(h) (expression). | RIP(m.s.){ub}n --A20(h)--> RIP(m.s.) + n ubiquitin(m.s.) (deubiquitination) | TRAF6(m.s.){ub{K63}(n)} --A20(h)--> TRAF6(m.s.) + ubiquitin(m.s.) (deubiquitination) | TRAF6(m){ub}n --A20(h)--> TRAF6(m) + n ubiquitin(m) (deubiquitination) | ubiquitin(h){ub{K48}(6)} --A20(h)--> ubiquitin(h){ub{K48}(5)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K48}(5)} --A20(h)--> ubiquitin(h){ub{K48}(4)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K48}(4)} --A20(h)--> ubiquitin(h){ub{K48}(3)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K48}(3)} --A20(h)--> ubiquitin(h){ub{K48}(2)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K48}(2)} --A20(h)--> ubiquitin(h){ub{K48}(1)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K63}(4)} --A20(h)--> ubiquitin(h){ub{K63}(3)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K63}(3)} --A20(h)--> ubiquitin(h){ub{K63}(2)} + ubiquitin(h) (deubiquitination) | ubiquitin(h){ub{K63}(2)} --A20(h)--> ubiquitin(h){ub{K63}(1)} + ubiquitin(h) (deubiquitination) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
575 | Phosphoserine. | Swiss-Prot 53.0 | 568 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 575 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 645 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr6 |
Promoter: 138228774 - 138230774 | Agilent_014791 |
chr6 |
Promoter: 138228774 - 138230774 | GSE27584 |
chr6 |
Promoter: 138228774 - 138230774 | Agilent_014791_44K |
chr6 |
Promoter: 138228774 - 138230774 | Agilent_014791 |