| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7158 |
Name | TP53BP1 |
Synonymous | 53BP1|p202|p53BP1;tumor protein p53 binding protein 1;TP53BP1;tumor protein p53 binding protein 1 |
Definition | p53-binding protein 1|tumor protein 53-binding protein, 1|tumor protein p53-binding protein, 1|tumor suppressor p53-binding protein 1 |
Position | 15q15-q21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
p53(h) + 53BP1(h) <==> p53(h):53BP1(h) (binding) | 53BP1(h) + ATP --ATM(h)--> 53BP1(h){p} + ADP (phosphorylation) | h2ax(h){p} + 53BP1(h) <==> h2ax(h){p}:53BP1(h) (binding) | 53BP1(h) + STAT1(h) <==> 53BP1(h):STAT1(h) (binding) | BLM(h) + 53BP1(h) <==> BLM(h):53BP1(h) (binding) | 53BP1(h) + PTIP(h) <==> 53BP1(h):PTIP(h) (binding) | 53BP1(h) + BLM(h) + p53(h) <==> 53BP1(h):BLM(h):p53(h) (binding) | Nek1(h) + 53BP1(h) <==> Nek1(h):53BP1(h) (binding) | 53BP1(h) --> BRCA1(h) (DNA binding). | 53BP1(h) --> BRCA1(m) (DNA binding). | 53BP1(h) --> BRCA1(r) (DNA binding). | 53BP1(h) + p300(h) <==> 53BP1(h):p300(h) (binding) | 53BP1(h) + p53(m) <==> 53BP1(h):p53(m) (binding) | 53BP1(h) + sumo1(h) --> 53BP1(h){sumo} (sumoylation) | 53BP1(h) + ATP --> 53BP1(h){pS25} + ADP (phosphorylation) | TP53BP1(h) --> 53BP1(h) (expression). | 53BP1-isoform1(h) + PTIP-xbb2(h) <==> 53BP1-isoform1(h):PTIP-xbb2(h) (binding) | 53BP1-isoform1(h) + sumo1(h) --> 53BP1-isoform1(h){sumo} (sumoylation) | TP53BP1(h) --> 53BP1-isoform1(h) (expression). | TP53BP1(h) --> 53BP1-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
294 | Phosphoserine. | Swiss-Prot 53.0 | 316 | Phosphoserine. | Swiss-Prot 53.0 | 380 | Phosphoserine. | Swiss-Prot 53.0 | 500 | Phosphoserine. | Swiss-Prot 53.0 | 525 | Phosphoserine. | Swiss-Prot 53.0 | 552 | Phosphoserine. | Swiss-Prot 53.0 | 580 | Phosphoserine. | Swiss-Prot 53.0 | 635 | Phosphoserine. | Swiss-Prot 53.0 | 639 | Phosphoserine. | Swiss-Prot 53.0 | 640 | Phosphoserine. | Swiss-Prot 53.0 | 659 | Phosphoserine. | Swiss-Prot 53.0 | 660 | Phosphoserine. | Swiss-Prot 53.0 | 662 | Phosphoserine. | Swiss-Prot 53.0 | 750 | Phosphothreonine. | Swiss-Prot 53.0 | 751 | Phosphoserine. | Swiss-Prot 53.0 | 754 | Phosphoserine. | Swiss-Prot 53.0 | 755 | Phosphoserine. | Swiss-Prot 53.0 | 771 | Phosphoserine. | Swiss-Prot 53.0 | 782 | Phosphoserine. | Swiss-Prot 53.0 | 831 | Phosphoserine. | Swiss-Prot 53.0 | 993 | Phosphoserine. | Swiss-Prot 53.0 | 996 | Phosphothreonine. | Swiss-Prot 53.0 | 999 | Phosphoserine. | Swiss-Prot 53.0 | 1002 | Phosphoserine. | Swiss-Prot 53.0 | 1028 | Phosphoserine. | Swiss-Prot 53.0 | 1056 | Phosphothreonine. | Swiss-Prot 53.0 | 1094 | Phosphoserine. | Swiss-Prot 53.0 | 1114 | Phosphoserine. | Swiss-Prot 53.0 | 1362 | Phosphoserine. | Swiss-Prot 53.0 | 1426 | Phosphoserine. | Swiss-Prot 53.0 | 1430 | Phosphoserine. | Swiss-Prot 53.0 | 1634 | Phosphoserine. | Swiss-Prot 53.0 | 1635 | Phosphoserine. | Swiss-Prot 53.0 | 1638 | Phosphothreonine. | Swiss-Prot 53.0 | 1673 | Phosphoserine. | Swiss-Prot 53.0 | 1678 | Phosphoserine. | Swiss-Prot 53.0 | 1701 | Phosphoserine. | Swiss-Prot 53.0 | 1705 | Phosphoserine. | Swiss-Prot 53.0 | 1114 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1028 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 294 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 552 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 525 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 6 | Phosphoserine (ATM) | 12697768 | Phospho.ELM 6.0 | 25 | Phosphoserine (ATM) | 12697768 | Phospho.ELM 6.0 | 29 | Phosphoserine (ATM) | 12697768 | Phospho.ELM 6.0 | 784 | Phosphoserine (ATM) | 12697768 | Phospho.ELM 6.0 | 500 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 1056 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 831 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 380 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 316 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 782 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1634 | Phosphoserine | 16094384 | Phospho.ELM 6.0 | 1635 | Phosphoserine | 16094384 | Phospho.ELM 6.0 | 1638 | Phosphothreonine | 16094384 | Phospho.ELM 6.0 | 222 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 265 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 379 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 523 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 548 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 580 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 635 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 639 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 640 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 659 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 660 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 662 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 750 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 751 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 754 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 755 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 899 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1068 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1094 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1101 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1214 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 1216 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1219 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1362 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1426 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1430 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1460 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1462 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1673 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1678 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1701 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1705 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1756 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 1758 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1759 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr15 |
Promoter: 41589528 - 41591528 | GSE27584 |
chr15 |
Promoter: 41589528 - 41591528 | Agilent_014791_44K |