Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7428

Name

VHL

Synonymous

HRCA1|RCA1|VHL1|pVHL;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase;VHL;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Definition

elongin binding protein|protein G7|von Hippel-Lindau disease tumor suppressor

Position

3p25.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

VHL(h) + TCP-1(h) <==> VHL(h):TCP-1(h) (binding)
VHL(h) + FIH-1(h) <==> VHL(h):FIH-1(h) (binding)
HIF-1alpha(h) + VHL(h) <==> HIF-1alpha(h):VHL(h) (binding)
VHL(h) + TCP-1(h) + Hsp70-1(h) <==> VHL(h):TCP-1(h):Hsp70-1(h) (binding)
VHL(h) + elongin B(r) + elongin C(r) <==> VHL(h):elongin B(r):elongin C(r) (binding)
HIF-1alpha(h){hydP567} + VHL(h) <==> HIF-1alpha(h){hydP567}:VHL(h) (binding)
HIF-1alpha(h){hydP564} + VHL(h) <==> HIF-1alpha(h){hydP564}:VHL(h) (binding)
HIF2A(h) + VHL(h) <==> HIF2A(h):VHL(h) (binding)
VHL(h) + Cul-2(h) <==> VHL(h):Cul-2(h) (binding)
VHL(h) + MO25(h) <==> VHL(h):MO25(h) (binding)
VHL(h) + Hic-5(h) <==> VHL(h):Hic-5(h) (binding)
VHL(h) + MPSK(h) <==> VHL(h):MPSK(h) (binding)
VHL(h) + phosphoribosylformylglycinamidine synthase(h) <==> VHL(h):phosphoribosylformylglycinamidine synthase(h) (binding)
VHL(h) + elongin C(h) <==> VHL(h):elongin C(h) (binding)
VHL(h) + PSMB1(h) <==> VHL(h):PSMB1(h) (binding)
VHL(h) + elongin B(h) <==> VHL(h):elongin B(h) (binding)
VHL(h) + RhoC(h) <==> VHL(h):RhoC(h) (binding)
VHL(h) + CNTF(h) <==> VHL(h):CNTF(h) (binding)
VHL(h) + Trx1(h) <==> VHL(h):Trx1(h) (binding)
VHL(h) + adenine phosphoribosyltransferase(h) <==> VHL(h):adenine phosphoribosyltransferase(h) (binding)
VHL(h) + Cdk2(h) <==> VHL(h):Cdk2(h) (binding)
VHL(h) + PKD1L3(h) <==> VHL(h):PKD1L3(h) (binding)
VHL(h) + Fascin(h) <==> VHL(h):Fascin(h) (binding)
VHL(h) + ILRS(h) <==> VHL(h):ILRS(h) (binding)
VHL(h) + PSMB3(h) <==> VHL(h):PSMB3(h) (binding)
VHL(h) + RasGRP(h) <==> VHL(h):RasGRP(h) (binding)
VHL(h) + Rab-1B(h) <==> VHL(h):Rab-1B(h) (binding)
VHL(h) + Roc1(h) <==> VHL(h):Roc1(h) (binding)
VHL(h) + Nedd8(h) <==> VHL(h):Nedd8(h) (binding)
VHL(h) + transgelin-2(h) <==> VHL(h):transgelin-2(h) (binding)
VHL(h) + PREI3(h) <==> VHL(h):PREI3(h) (binding)
VHL(h) + CCDC59(h) <==> VHL(h):CCDC59(h) (binding)
VHL(h) + TRIP-8(h) <==> VHL(h):TRIP-8(h) (binding)
VHL(h) + cysteine dioxygenase type 1(h) <==> VHL(h):cysteine dioxygenase type 1(h) (binding)
VHL(h) + TEBP(h) <==> VHL(h):TEBP(h) (binding)
VHL(h) + bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2(h) <==> VHL(h):bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2(h) (binding)
VHL(h) + hist1h2bc(h) <==> VHL(h):hist1h2bc(h) (binding)
VHL(h) + CCDC82(h) <==> VHL(h):CCDC82(h) (binding)
VHL(h) + psmd13(h) <==> VHL(h):psmd13(h) (binding)
VHL(h) + ThrRS(h) <==> VHL(h):ThrRS(h) (binding)
VHL(h) + TCTP(h) <==> VHL(h):TCTP(h) (binding)
VHL(h) + RPA3(h) <==> VHL(h):RPA3(h) (binding)
VHL(h) + Rod(h) <==> VHL(h):Rod(h) (binding)
VHL(h) + MCC1(h) <==> VHL(h):MCC1(h) (binding)
VHL(h) + PIMT(h) <==> VHL(h):PIMT(h) (binding)
VHL(h) + Rab7(h) <==> VHL(h):Rab7(h) (binding)
VHL(h) + STFB(h) <==> VHL(h):STFB(h) (binding)
VHL(h) + CstF-77(h) <==> VHL(h):CstF-77(h) (binding)
VHL(h) + HAS(h) <==> VHL(h):HAS(h) (binding)
VHL(h) + rps9(h) <==> VHL(h):rps9(h) (binding)
VHL(h) + IMPDH2(h) <==> VHL(h):IMPDH2(h) (binding)
VHL(h) + Ataxin2(h) <==> VHL(h):Ataxin2(h) (binding)
VHL(h) + CHMP2b(h) <==> VHL(h):CHMP2b(h) (binding)
VHL(h) + Pin1(h) <==> VHL(h):Pin1(h) (binding)
VHL(h) + MLC-2(h) <==> VHL(h):MLC-2(h) (binding)
VHL(h) + CypB(h) <==> VHL(h):CypB(h) (binding)
VHL(h) --> VHL(h) (expression).
HIF-1alpha(h) + n ubiquitin(h) --VHL(h)--> HIF-1alpha(h){ub(n)} (ubiquitination)
HIF2A(h) + n ubiquitin(h) --VHL(h)--> HIF2A(h){ub(n)} (ubiquitination)
VHL(h) --> VHL-isoform1(h) (expression).
VHL(h) --> VHL-isoform2(h) (expression).
VHL(h) --> VHL-isoform3(h) (expression).

Post Transcriptional Modification   [Top]

There is no record for VHL

Methylation Profile   [Top]

Chromosome

Location

Source

chr3

 Promoter: 10156819 - 10158819Agilent_014791

chr3

 Promoter: 10156819 - 10158819GSE27584

chr3

 Promoter: 10156819 - 10158819GSE27584

chr3

 Promoter: 10156819 - 10158819Agilent_014791_44K

chr3

 Promoter: 10156819 - 10158819PMID:9624531

chr3

 Promoter: 10156819 - 10158819PMID:9624531

chr3

 Promoter: 10156819 - 10158819PMID:15217927

chr3

 Promoter: 10156819 - 10158819PMID:15217927

chr3

 Promoter: 10156819 - 10158819PMID:7937876

chr3

 Promoter: 10156819 - 10158819PMID:7937876

chr3

 Promoter: 10156819 - 10158819PMID:16983315

chr3

 Promoter: 10156819 - 10158819PMID:16983315

chr3

 Promoter: 10156819 - 10158819PMID:15892004

chr3

 Promoter: 10156819 - 10158819PMID:15892004

chr3

 Promoter: 10156819 - 10158819PMID:12124340

chr3

 Promoter: 10156819 - 10158819PMID:12124340

chr3

 Promoter: 10156819 - 10158819PMID:12839965

chr3

 Promoter: 10156819 - 10158819PMID:12839965

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