| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8554 |
Name | PIAS1 |
Synonymous | DDXBP1|GBP|GU/RH-II|ZMIZ3;protein inhibitor of activated STAT, 1;PIAS1;protein inhibitor of activated STAT, 1 |
Definition | AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activ |
Position | 15q |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
p53(h) + PIAS1(h) <==> p53(h):PIAS1(h) (binding) | PIAS1(h) + sumo1(v.s.) <==> PIAS1(h):sumo1(v.s.) (binding) | PIAS1(h) + Ubc9(v.s.) <==> PIAS1(h):Ubc9(v.s.) (binding) | PIAS1(h) + p53(v.s.) <==> PIAS1(h):p53(v.s.) (binding) | PIAS1(h) + c-Jun(m) <==> PIAS1(h):c-Jun(m) (binding) | ER-alpha-L(h) + PIAS1(h) <==> ER-alpha-L(h):PIAS1(h) (binding) | PIAS1(h) + NF2d9-CP2b(m) <==> PIAS1(h):NF2d9-CP2b(m) (binding) | PIAS1(h) + ITF-2(h) <==> PIAS1(h):ITF-2(h) (binding) | cystathionine beta-synthase isoform-1(h) + PIAS1(h) <==> cystathionine beta-synthase isoform-1(h):PIAS1(h) (binding) | NIN-isoform1(h) + PIAS1(h) <==> NIN-isoform1(h):PIAS1(h) (binding) | MR-isoform1(h) + PIAS1(h) <==> MR-isoform1(h):PIAS1(h) (binding) | PIAS1(h) + p73alpha(h) <==> PIAS1(h):p73alpha(h) (binding) | AIRE(m.s.) + PIAS1(h) <==> AIRE(m.s.):PIAS1(h) (binding) | PIAS1(h) --> brca1(h){sumo} (increase of sumoylation) | PIAS1(h) --> brca1(h){sumo2} (increase of sumoylation) | PIAS1(h) --> brca1(m.s.){sumo2} (increase of sumoylation) | PIAS1(h) --> RPA2(h){pS4}{pS8} (increase of phosphorylation) | PIAS1(h) --> PIAS1(h) (expression). | p53(v.s.) + sumo1(v.s.) --PIAS1(h)--> p53(v.s.){sumo} (sumoylation) | p53(v.s.) + sumo1(v.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS1(h)--> p53(v.s.){sumo} (sumoylation) | p53(v.s.) + sumo1(v.s.) --Aos1(d):SAE2(d),Ubc9(v.s.),PIAS1(h)--> p53(v.s.){sumo} (sumoylation) | c-Jun(m) + sumo1(v.s.) --Aos1(d):SAE2(d),Ubc9(v.s.),PIAS1(h)--> c-Jun(m){sumo} (sumoylation) | Sox9(m.s.) + PIAS1(h) <==> Sox9(m.s.):PIAS1(h) (binding) | MR-isoform1(h) + PIAS1(h) <==> MR-isoform1(h):PIAS1(h) (binding) | PIAS1(h) --> PIAS1(h) (expression). | MR-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),PIAS1(h),Ubc9(m.s.)--> MR-isoform1(h){sumo} (sumoylation) | MR-isoform1(h) + sumo1(h) --PIAS1(h)--> MR-isoform1(h){sumo} (sumoylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
466 | Phosphoserine. | Swiss-Prot 53.0 | 467 | Phosphoserine. | Swiss-Prot 53.0 | 468 | Phosphoserine. | Swiss-Prot 53.0 | 483 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 485 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 487 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 466 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 467 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 468 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 483 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr15 |
Promoter: 66132126 - 66134126 | Agilent_014791 |
chr15 |
Promoter: 66132126 - 66134126 | GSE27584 |
chr15 |
Promoter: 66132126 - 66134126 | Agilent_014791_44K |