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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10181 |
Name | RBM5 |
Synonym | G15|LUCA15|RMB5;RNA binding motif protein 5;RBM5;RNA binding motif protein 5 |
Definition | RNA-binding protein 5|putative tumor suppressor LUCA15|renal carcinoma antigen NY-REN-9 |
Position | 3p21.3 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 7 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "RBM5/H37 tumor suppressor, located at the lung cancer hot spot 3p21.3, alters expression of genes involved in metastasis." |
potential | p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. |
reviewed | Death by splicing: tumor suppressor RBM5 freezes splice-site pairing. |
potential | "Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5." |
reviewed | Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus. |
reviewed | 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. |
potential | Results suggest that LUCA-15 plays a central role in regulating cell fate consistent with its tumor suppressor activity. |
| More detail of all 7 literatures about RBM5 | |
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Pathways and Diseases |
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Pathway | mRNA Splicing - Major Pathway;PID Reactome;500866 |
Pathway | Gene Expression;Reactome;REACT:71 |
Pathway | mRNA Processing;Reactome;REACT:1675 |
Disease | Cancer;FunDO |
Disease | Lung cancer;FunDO |
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External Links |
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Links to Entrez Gene | 10181 |
Links to all GeneRIF Items | 10181 |
Links to iHOP | 10181 |
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Sequence Information |
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Nucleotide Sequence |
>10181 : length: 2448 atgggttcagacaaaagagtgagtagaacagagcgtagtggaagatacggttccatcata gacagggatgaccgtgatgagcgtgaatcccgaagcaggcggagggactcagattacaaa agatctagtgatgatcggaggggtgatagatatgatgactaccgagactatgacagtcca gagagagagcgtgaaagaaggaacagtgaccgatccgaagatggctaccattcagatggt gactatggtgagcacgactataggcatgacatcagtgacgagagggagagcaagaccatc atgctgcgcggccttcccatcaccatcacagagagcgatattcgagaaatgatggagtcc ttcgaaggccctcagcctgcggatgtgaggctgatgaagaggaaaacaggtgtaagccgt ggtttcgccttcgtggagttttatcacttgcaagatgctaccagctggatggaagccaat cagaaaaagttggtgattcaaggaaagcacattgcaatgcattatagcaatcccagacct aagtttgaagattggctttgtaacaagtgctgccttaacaatttcaggaaaagactaaaa tgcttccgatgtggagcagacaagtttgactctgaacaggaagtgcctcctggaaccaca gagtcggttcagtctgtggattactactgtgatacgatcattcttcggaacatagctccg cacactgtggtggattccatcatgacagcactgtctccttacgcgtctttagctgtcaat aacatccgcctcataaaagacaaacagacccagcagaacagaggcttcgcatttgtgcag ctgtcctctgcaatggatgcttctcagctgcttcagatattacagagtctccatcctcct ttgaaaattgatggcaaaactattggggttgattttgcaaaaagtgccagaaaagacttg gtcctctcagatggtaaccgcgtcagcgctttctctgtagctagtacggctattgctgct gctcagtggtcatccacccagtctcaaagtggtgaaggaggcagtgttgactacagttat ctgcaaccaggtcaagatggctatgcccaatatgctcagtattcacaggattatcagcag ttttatcaacaacaagctggaggattggaatctgatgcatcatctgcatcaggcacagca gtgaccaccacctcagcggctgtagtgtcccagagtcctcagctgtataatcaaacctcc aatccacctggctctccgactgaggaagcacagcctagcactagcacaagtacacaggcc ccagccgcttcccctactggtgtagttcctggtaccaaatatgcagtacctgacacgtcc acttaccagtatgatgaatcttcaggatattactatgatccgacaacagggctctattat gaccccaactcgcaatactactataattccttgacccagcagtacctttactgggatggg gaaaaagagacctacgtgccagctgcagagtctagctcccaccagcagtcgggcctgcct cctgcaaaagaggggaaagagaagaaggagaaacccaagagcaaaacagcccagcagatt gccaaagacatggaacgctgggctaagagtttgaataagcagaaagaaaactttaaaaat agctttcagcctgtcaattccttgagggaagaagaaaggagagaatctgctgcagcagac gctggctttgctctctttgagaagaagggagccttagctgaaaggcagcagctcatccca gaattggtgcgaaatggagatgaggagaatcccctcaaaaggggtctggttgctgcttac agtggtgacagtgacaatgaggaggagctggtggagagacttgagagtgaggaagagaag ctagctgactggaagaagatggcctgtctgctctgccggcgccagttcccgaacaaagat gccctagtcaggcaccagcaactctcagaccttcacaagcaaaacatggacatctatcga cgatccaggctgagcgagcaggagctggaagccttggagctaagggagagagagatgaaa taccgagaccgagctgcagaaagacgggagaagtacggcattccagaacctccagagccc aagcgcaagaagcagtttgatgccggcactgtgaattacgagcaacccaccaaagatggc attgaccacagtaacattggcaacaagatgctgcaggccatgggctggcgggaaggctct ggcttgggacgaaagtgtcaaggcattacggctcccattgaggctcaagttcggctaaag ggagctggcctaggagccaaaggcagcgcatatggtttgtcgggcgccgattcctacaaa gatgctgtccggaaagccatgtttgcccggttcactgagatggagtga |
Protein Sequence |
>10181 : length: 815 MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSP ERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMES FEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRP KFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAP HTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPP LKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSY LQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSPQLYNQTS NPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYY DPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQI AKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLIP ELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNKD ALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEP KRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLK GAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME |