|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 10210 |
Name | TOPORS |
Synonym | LUN|P53BP3|RP31|TP53BPL;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase;TOPORS;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase Topors|SUMO1-protein E3 ligase Topors|topoisomerase I-binding RING finger protein|tumor suppressor p53-binding protein 3 |
Position | 9p21 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 3 PubMed records as below. |
|
Evidence Status |
Description |
potential | The findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification. |
potential | "topors mediates p53-dependent cellular responses induced by DNA damage, suggesting its physiological role as a tumor suppressor". |
potential | "topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor". |
| More detail of all 3 literatures about TOPORS | |
|
External Links |
|
Links to Entrez Gene | 10210 |
Links to all GeneRIF Items | 10210 |
Links to iHOP | 10210 |
|
Sequence Information |
|
Nucleotide Sequence |
>10210 : length: 2943 atgataatggcatcagctgctaaggaatttaaaatggacaacttttcacctaaagctggc actagcaaattgcaacagacagtaccagctgatgcatctcctgattctaagtgtcctata tgcttggatagatttgataatgtgtcttacttagatcgctgcttacataagttctgtttt cgctgtgtacaggagtggtcaaaaaacaaagctgaatgcccactatgtaaacagcccttt gattctattttccattctgtgagggcagaagatgacttcaaggagtatgtcctaaggcct tcgtataatggttcttttgtcacccctgatcgacgatttcgctaccgtacaactctgaca agggaacgaaatgcttctgtgtattcacctagtggtcctgtgaacagaagaacaacaact ccaccggatagtggagtactgtttgaagggttaggcatttcaacaagacctagagatgtt gaaattcctcagtttatgagacagattgcagtaaggaggccaactacggcagatgaaaga tctttgcggaaaattcaagaacaagatattattaattttagacgaactctttatcgtgct ggtgctcgagttagaaatattgaagatggtggccgctacagggatatttcagctgaattt ttccgtagaaatccagcttgccttcacagattagtcccctggttaaaacgtgaacttaca gttctttttggagctcatggatctttagtgaatattgtccagcatattatcatgagtaat gttactcgctatgacttggagagtcaggcatttgtgtctgatttaagaccatttttactt aatcgaactgagcattttatacatgaatttatcagttttgcccgatctccttttaacatg gcagcctttgaccagcatgccaattatgattgccctgctccttcatacgaagaaggcagc cattctgattcttcagtcataacaatatctccagatgaggctgagacccaagagctggat attaatgtagccactgttagtcaggcaccatgggatgatgaaactccaggaccatcttac tcaagctcagagcaggtacacgttactatgtcttctcttttaaatacttctgacagttca gatgaagaacttgtcacaggaggagccacgtctcagatacaaggagtacaaaccaatgac gacctaaataatgacagtgatgattcttcagataattgtgtcattgttgggtttgttaaa ccactagctgagaggaccccagaacttgttgaactgtcctctgattctgaggacttaggt tcttatgagaaaatggagacagtgaagacacaagaacaggagcaatcttacagttctggt gatagcgatgttagtagatgctcatctccacactctgtccttggaaaggatgaacaaata aataaaggtcattgtgattctagtacaagaatcaaatcaaagaaggaagagaaacgatct acatcattgtcatctcccagaaacctgaactcatctgtaagaggagacagagtatattct ccatataaccatagacacagaaagaggggaagatcaagaagttcagattcacgttctcag agtagaagtgggcatgatcagaagaatcatagaaagcatcatgggaagaaaagaatgaaa agtaaacgatccagaagcagggaaagtagcagacctagagggagaagagacaaaaagaga tcaagaactagagatagcagttggtccagaagaagccaaactctgtctctaagtagtgaa agcacaagcagatcaaggtctcgtagcagtgatcatggtaaaagaagatcacggagcaga aatagagatcgttattatttaagaaataattatggaagcagatacaaatgggagtatact tattacagtagaaacaaggacagggatgggtacgaatcatcttacaggaggaggactctg tccagagctcattattctagacagtcttcaagtccagaatttagagttcagtccttttct gaaagaacaaatgctaggaaaaaaaataatcacagtgagaggaagtattactactatgaa aggcacagatcaaggagcctgtctagtaacagatcaaggactgcatctaccgggactgac cgggtgagaaatgaaaagcctggagggaaacgaaaatacaaaacacggcatttggagggt actaacgaagtggctcagccatctcgtgaatttgcttctaaagcaaaggacagtcattac caaaaatcttcatcaaaattggatggaaactacaaaaatgagagtgataccttttcagac agccgatcatcagacagagagacaaaacacaaaaggagaaaaaggaagacccggagccta agtgtagagatagtttatgaaggaaaagctactgatacaactaaacaccataaaaagaaa aagaagaaacataagaagaagcataagaaacaccatggagataatgcttcacgttcccca gttgtaattaccattgacagtgacagtgataaggattctgaagtaaaggaggatacagaa tgtgacaatagtggtcctcaagaccctctacaaaatgagtttttggctccttccttggaa ccatttgaaactaaagatgtagttacaatagaagctgaatttggtgtgctggacaaggaa tgtgatattgccacacttagtaacaacttgaataatgccaacaaaactgtagataatatt ccacctctggcagcttcagttgaacaaactctcgatgtaagagaagagagcacctttgtt tctgatttggagaaccagcccagtaacattgtgtctcttcaaactgagccatcaaggcaa ttgccatcgccacggacatcattaatgtcagtatgtcttggtagagactgtgatatgtct taa |
Protein Sequence |
>10210 : length: 980 MIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCF RCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLT RERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADER SLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELT VLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNM AAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSY SSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVK PLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQI NKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQ SRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSE STSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTL SRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTD RVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSD SRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSP VVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKE CDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQ LPSPRTSLMSVCLGRDCDMS |