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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 10210 |
Name | TOPORS |
Synonymous | LUN|P53BP3|RP31|TP53BPL;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase;TOPORS;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase |
Definition | E3 ubiquitin-protein ligase Topors|SUMO1-protein E3 ligase Topors|topoisomerase I-binding RING finger protein|tumor suppressor p53-binding protein 3 |
Position | 9p21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
LUN-isoform1(h) --> CDH1(h) (DNA binding). | LUN-isoform1(h) --> TLN(h) (DNA binding). | TOPORS(h) --> LUN-isoform1(h) (expression). | p53(m.s.) + sumo1(m.s.) --LUN-isoform1(h)--> p53(m.s.){sumo} (sumoylation) | p53(m.s.) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h),LUN-isoform1(h)--> p53(m.s.){sumo} (sumoylation) | p53(m.s.) + ubiquitin(m.s.) --Ubc5A(m.s.),LUN-isoform1(h)--> p53(m.s.){ub} (ubiquitination) | p53(h) + n ubiquitin(h) --LUN-isoform1(h)--> p53(h){ub}n (ubiquitination) | TOPORS(h) --> LUN-isoform2(h) (expression). | TOPORS(h) --> LUN(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
98 | Phosphoserine. | Swiss-Prot 53.0 | 902 | Phosphoserine. | Swiss-Prot 53.0 | 912 | Phosphoserine. | Swiss-Prot 53.0 | 914 | Phosphoserine. | Swiss-Prot 53.0 | 560 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO). | Swiss-Prot 53.0 | 98 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 902 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 912 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 914 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 918 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
There is no record for TOPORS |