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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 11184 |
Name | MAP4K1 |
Synonym | HPK1;mitogen-activated protein kinase kinase kinase kinase 1;MAP4K1;mitogen-activated protein kinase kinase kinase kinase 1 |
Definition | MAPK/ERK kinase kinase kinase 1|MEK kinase kinase 1|MEKKK 1|hematopoietic progenitor kinase 1 |
Position | 19q13.1-q13.4 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. |
| More detail of all 1 literatures about MAP4K1 | |
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Pathways and Diseases |
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Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 11184 |
Links to all GeneRIF Items | 11184 |
Links to iHOP | 11184 |
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Sequence Information |
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Nucleotide Sequence |
>11184 : length: 2466 atggacgtcgtggaccctgacattttcaatagagacccccgggaccactatgacctgcta cagcggctgggtggcggcacgtatggggaagtctttaaggctcgagacaaggtgtcaggg gacctggtggcactgaagatggtgaagatggagcctgatgatgatgtctccacccttcag aaggaaatcctcatattgaaaacttgccggcacgccaacatcgtggcctaccatgggagt tatctctggttgcagaaactctggatctgcatggaattctgtggggctggttctctccag gacatctaccaagtgacaggctccctgtcagagctccagattagctatgtctgccgggaa gtgctccagggactggcctatttgcactcacagaagaagatacacagggacatcaaggga gctaacatcctcatcaatgatgctggggaggtcagattggctgactttggcatctcggcc cagattggggctacactggccagacgcctctctttcattgggacaccctactggatggct ccggaagtggcagctgtggccctgaagggaggatacaatgagctgtgtgacatctggtcc ctgggcatcacggccatcgaactggccgagctacagccaccgctctttgatgtgcaccct ctcagagttctcttcctcatgaccaagagtggctaccagcctccccgactgaaggaaaaa ggcaaatggtcggctgccttccacaacttcatcaaagtcactctgactaagagtcccaag aaacgacccagcgccaccaagatgctcagtcatcaactggtatcccagcctgggctgaat cgaggcctgatcctggatcttcttgacaaactgaagaatcccgggaaaggaccctccatt ggggacattgaggatgaggagcccgagctaccccctgctatccctcggcggatcagatcc acccaccgctccagctctctggggatcccagatgcagactgctgtcggcggcacatggag ttcaggaagctccgaggaatggagaccagacccccagccaacaccgctcgcctacagcct cctcgagacctcaggagcagcagccccaggaagcaactgtcagagtcgtctgacgatgac tatgacgacgtggacatccccacccctgcagaggacacacctcctccacttccccccaag cccaagttccgttctccatcagacgagggtcctgggagcatgggggatgatgggcagctg agcccgggggtgctggtccggtgtgccagtgggcccccaccaaacagcccccgtcctggg cctcccccatccaccagcagcccccacctcaccgcccattcagaaccctcactctggaac ccaccctcccgggagcttgacaagcccccacttctgccccccaagaaggaaaagatgaag agaaagggatgtgcccttctcgtaaagttgttcaatggctgccccctccggatccacagc acggccgcctggacacatccctccaccaaggaccagcacctgctcctgggggcagaggaa ggcatcttcatcctgaaccggaatgaccaggaggccacgctggaaatgctctttcctagc cggactacgtgggtgtactccatcaacaacgttctcatgtctctctcaggaaagaccccc cacctgtattctcatagcatccttggcctgctggaacggaaagagaccagagcaggaaac cccatcgctcacattagcccccaccgcctactggcaaggaagaacatggtttccaccaag atccaggacaccaaaggctgccgggcgtgctgtgtggcggagggtgcgagctctgggggc ccgttcctgtgcggtgcattggagacgtccgttgtcctgcttcagtggtaccagcccatg aacaaattcctgcttgtccggcaggtgctgttcccactgccgacgcctctgtccgtgttc gcgctgctgaccgggccaggctctgagctgcccgctgtgtgcatcggcgtgagccccggg cggccggggaagtcggtgctcttccacacggtgcgctttggcgcgctctcttgctggctg ggcgagatgagcaccgagcacaggggacccgtgcaggtgacccaggtagaggaagatatg gtgatggtgttgatggatggctctgtgaagctggtgaccccggaggggtccccagtccgg ggacttcgcacacctgagatccccatgaccgaagcggtggaggccgtggctatggttgga ggtcagcttcaggccttctggaagcatggagtgcaggtgtgggctctaggctcggatcag ctgctacaggagctgagagaccctaccctcactttccgtctgcttggctcccccaggcct gtagtggtggagacacgcccagtggatgatcctactgctcccagcaacctctacatccag gaatga |
Protein Sequence |
>11184 : length: 821 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ LLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYIQE |