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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1387 |
Name | CREBBP |
Synonym | CBP|KAT3A|RSTS;CREB binding protein;CREBBP;CREB binding protein |
Definition | CREB-binding protein |
Position | 16p13.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The identification of CBP inactivating mutations in conjunction with disruption of the second CBP allele strongly suggests that CBP is a tumour suppressor gene that contributes to ovarian tumorigenesis in humans. |
reviewed | CBP is a multifunctional transcriptional cofactor with tumor suppressor activity. Its CH3 domain binds to Sam68 in part through a conserved amino acid motif. |
| More detail of all 2 literatures about CREBBP | |
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Pathways and Diseases |
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Pathway | transcription regulation by methyltransferase of carm1;PID BioCarta;100220 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088 |
Pathway | multi-step regulation of transcription by pitx2;PID BioCarta;100074 |
Pathway | mechanism of gene regulation by peroxisome proliferators via ppara;PID BioCarta;100066 |
Pathway | Notch-HLH transcription pathway;PID Reactome;500905 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | regulation of transcriptional activity by pml;PID BioCarta;100067 |
Pathway | FOXA1 transcription factor network;PID Curated;200194 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | IL12 signaling mediated by STAT4;PID Curated;200197 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | role of ppar-gamma coactivators in obesity and thermogenesis;PID BioCarta;100065 |
Pathway | Hedgehog signaling pathway;PANTHER;P00025 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk);PID BioCarta;100148 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | the information processing pathway at the ifn beta enhancer;PID BioCarta;100079 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | Gene Expression;Reactome;REACT:71 |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | carm1 and regulation of the estrogen receptor;PID BioCarta;100219 |
Pathway | pelp1 modulation of estrogen receptor activity;PID BioCarta;100076 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | wnt signaling pathway;PID BioCarta;100002 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | acetylation and deacetylation of rela in nucleus;PID BioCarta;100043 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | granzyme a mediated apoptosis pathway;PID BioCarta;100035 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | Transcription regulation by bZIP transcription factor;PANTHER;P00055 |
Pathway | Signaling events mediated by HDAC Class I;PID Curated;200070 |
Pathway | il-7 signal transduction;PID BioCarta;100125 |
Pathway | Notch signaling pathway;KEGG PATHWAY;hsa04330 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | control of gene expression by vitamin d receptor;PID BioCarta;100007 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors;PID BioCarta;100140 |
Disease | Neuroblastoma;FunDO |
Disease | Rubenstein-Taybi syndrome;OMIM |
Disease | Prostate cancer;FunDO |
Disease | Mucopolysaccharidosis;FunDO |
Disease | Aseptic necrosis of bone;FunDO |
Disease | Lung cancer;FunDO |
Disease | Leukemia;FunDO |
Disease | Rheumatism;FunDO |
Disease | Leukoencephalopathy;FunDO |
Disease | Esophagus cancer;FunDO |
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External Links |
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Links to Entrez Gene | 1387 |
Links to all GeneRIF Items | 1387 |
Links to iHOP | 1387 |
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Sequence Information |
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Nucleotide Sequence |
>1387 : length: 7215 atggctgagaacttgctggacggaccgcccaaccccaaaagagccaaactcagctcgccc ggtttctcggcgaatgacagcacagattttggatcattgtttgacttggaaaatgatctt cctgatgagctgatacccaatggaggagaattaggccttttaaacagtgggaaccttgtt ccagatgctgcttccaaacataaacaactgtcggagcttctacgaggaggcagcggctct agtatcaacccaggaataggaaatgtgagcgccagcagccccgtgcagcagggcctgggt ggccaggctcaagggcagccgaacagtgctaacatggccagcctcagtgccatgggcaag agccctctgagccagggagattcttcagcccccagcctgcctaaacaggcagccagcacc tctgggcccacccccgctgcctcccaagcactgaatccgcaagcacaaaagcaagtgggg ctggcgactagcagccctgccacgtcacagactggacctggtatctgcatgaatgctaac tttaaccagacccacccaggcctcctcaatagtaactctggccatagcttaattaatcag gcttcacaagggcaggcgcaagtcatgaatggatctcttggggctgctggcagaggaagg ggagctggaatgccgtaccctactccagccatgcagggcgcctcgagcagcgtgctggct gagaccctaacgcaggtttccccgcaaatgactggtcacgcgggactgaacaccgcacag gcaggaggcatggccaagatgggaataactgggaacacaagtccatttggacagcccttt agtcaagctggagggcagccaatgggagccactggagtgaacccccagttagccagcaaa cagagcatggtcaacagtttgcccaccttccctacagatatcaagaatacttcagtcacc aacgtgccaaatatgtctcagatgcaaacatcagtgggaattgtacccacacaagcaatt gcaacaggccccactgcagatcctgaaaaacgcaaactgatacagcagcagctggttcta ctgcttcatgctcataagtgtcagagacgagagcaagcaaacggagaggttcgggcctgc tcgctcccgcattgtcgaaccatgaaaaacgttttgaatcacatgacgcattgtcaggct gggaaagcctgccaagccatcctggggtctccagctagtggaattcaaaacacaattggt tctgttggcacagggcaacagaatgccacttctttaagtaacccaaatcccatagacccc agctccatgcagcgagcctatgctgctctcggactcccctacatgaaccagccccagacg cagctgcagcctcaggttcctggccagcaaccagcacagcctcaaacccaccagcagatg aggactctcaaccccctgggaaataatccaatgaacattccagcaggaggaataacaaca gatcagcagcccccaaacttgatttcagaatcagctcttccgacttccctgggggccaca aacccactgatgaacgatggctccaactctggtaacattggaaccctcagcactatacca acagcagctcctccttctagcaccggtgtaaggaaaggctggcacgaacatgtcactcag gacctgcggagccatctagtgcataaactcgtccaagccatcttcccaacacctgatccc gcagctctaaaggatcgccgcatggaaaacctggtagcctatgctaagaaagtggaaggg gacatgtacgagtctgccaacagcagggatgaatattatcacttattagcagagaaaatc tacaagatacaaaaagaactagaagaaaaacggaggtcgcgtttacataaacaaggcatc ttggggaaccagccagccttaccagccccgggggctcagccccctgtgattccacaggca caacctgtgagacctccaaatggacccctgtccctgccagtgaatcgcatgcaagtttct caagggatgaattcatttaaccccatgtccttggggaacgtccagttgccacaagcaccc atgggacctcgtgcagcctccccaatgaaccactctgtccagatgaacagcatgggctca gtgccagggatggccatttctccttcccgaatgcctcagcctccgaacatgatgggtgca cacaccaacaacatgatggcccaggcgcccgctcagagccagtttctgccacagaaccag ttcccgtcatccagcggggcgatgagtgtgggcatggggcagccgccagcccaaacaggc gtgtcacagggacaggtgcctggtgctgctcttcctaaccctctcaacatgctggggcct caggccagccagctaccttgccctccagtgacacagtcaccactgcacccaacaccgcct cctgcttccacggctgctggcatgccatctctccagcacacgacaccacctgggatgact cctccccagccagcagctcccactcagccatcaactcctgtgtcgtcttccgggcagact cccaccccgactcctggctcagtgcccagtgctacccaaacccagagcacccctacagtc caggcagcagcccaggcccaggtgaccccgcagcctcaaaccccagttcagcccccgtct gtggctacccctcagtcatcgcagcaacagccgacgcctgtgcacgcccagcctcctggc acaccgctttcccaggcagcagccagcattgataacagagtccctaccccctcctcggtg gccagcgcagaaaccaattcccagcagccaggacctgacgtacctgtgctggaaatgaag acggagacccaagcagaggacactgagcccgatcctggtgaatccaaaggggagcccagg tctgagatgatggaggaggatttgcaaggagcttcccaagttaaagaagaaacagacata gcagagcagaaatcagaaccaatggaagtggatgaaaagaaacctgaagtgaaagtagaa gttaaagaggaagaagagagtagcagtaacggcacagcctctcagtcaacatctccttcg cagccgcgcaaaaaaatctttaaaccagaggagttacgccaggccctcatgccaacccta gaagcactgtatcgacaggacccagagtcattacctttccggcagcctgtagatccccag ctcctcggaattccagactattttgacatcgtaaagaatcccatggacctctccaccatc aagcggaagctggacacagggcaataccaagagccctggcagtacgtggacgacgtctgg ctcatgttcaacaatgcctggctctataatcgcaagacatcccgagtctataagttttgc agtaagcttgcagaggtctttgagcaggaaattgaccctgtcatgcagtcccttggatat tgctgtggacgcaagtatgagttttccccacagactttgtgctgctatgggaagcagctg tgtaccattcctcgcgatgctgcctactacagctatcagaataggtatcatttctgtgag aagtgtttcacagagatccagggcgagaatgtgaccctgggtgacgacccttcacagccc cagacgacaatttcaaaggatcagtttgaaaagaagaaaaatgataccttagaccccgaa cctttcgttgattgcaaggagtgtggccggaagatgcatcagatttgcgttctgcactat gacatcatttggccttcaggttttgtgtgcgacaactgcttgaagaaaactggcagacct cgaaaagaaaacaaattcagtgctaagaggctgcagaccacaagactgggaaaccacttg gaagaccgagtgaacaaatttttgcggcgccagaatcaccctgaagccggggaggttttt gtccgagtggtggccagctcagacaagacggtggaggtcaagcccgggatgaagtcacgg tttgtggattctggggaaatgtctgaatctttcccatatcgaaccaaagctctgtttgct tttgaggaaattgacggcgtggatgtctgcttttttggaatgcacgtccaagaatacggc tctgattgcccccctccaaacacgaggcgtgtgtacatttcttatctggatagtattcat ttcttccggccacgttgcctccgcacagccgtttaccatgagatccttattggatattta gagtatgtgaagaaattagggtatgtgacagggcacatctgggcctgtcctccaagtgaa ggagatgattacatcttccattgccacccacctgatcaaaaaatacccaagccaaaacga ctgcaggagtggtacaaaaagatgctggacaaggcgtttgcagagcggatcatccatgac tacaaggatattttcaaacaagcaactgaagacaggctcaccagtgccaaggaactgccc tattttgaaggtgatttctggcccaatgtgttagaagagagcattaaggaactagaacaa gaagaagaggagaggaaaaaggaagagagcactgcagccagtgaaaccactgagggcagt cagggcgacagcaagaatgccaagaagaagaacaacaagaaaaccaacaagaacaaaagc agcatcagccgcgccaacaagaagaagcccagcatgcccaacgtgtccaatgacctgtcc cagaagctgtatgccaccatggagaagcacaaggaggtcttcttcgtgatccacctgcac gctgggcctgtcatcaacaccctgccccccatcgtcgaccccgaccccctgctcagctgt gacctcatggatgggcgcgacgccttcctcaccctcgccagagacaagcactgggagttc tcctccttgcgccgctccaagtggtccacgctctgcatgctggtggagctgcacacccag ggccaggaccgctttgtctacacctgcaacgagtgcaagcaccacgtggagacgcgctgg cactgcactgtgtgcgaggactacgacctctgcatcaactgctataacacgaagagccat gcccataagatggtgaagtgggggctgggcctggatgacgagggcagcagccagggcgag ccacagtcaaagagcccccaggagtcacgccggctgagcatccagcgctgcatccagtcg ctggtgcacgcgtgccagtgccgcaacgccaactgctcgctgccatcctgccagaagatg aagcgggtggtgcagcacaccaagggctgcaaacgcaagaccaacgggggctgcccggtg tgcaagcagctcatcgccctctgctgctaccacgccaagcactgccaagaaaacaaatgc cccgtgcccttctgcctcaacatcaaacacaagctccgccagcagcagatccagcaccgc ctgcagcaggcccagctcatgcgccggcggatggccaccatgaacacccgcaacgtgcct cagcagagtctgccttctcctacctcagcaccgcccgggacccccacacagcagcccagc acaccccagacgccgcagccccctgcccagccccaaccctcacccgtgagcatgtcacca gctggcttccccagcgtggcccggactcagccccccaccacggtgtccacagggaagcct accagccaggtgccggcccccccacccccggcccagccccctcctgcagcggtggaagcg gctcggcagatcgagcgtgaggcccagcagcagcagcacctgtaccgggtgaacatcaac aacagcatgcccccaggacgcacgggcatggggaccccggggagccagatggcccccgtg agcctgaatgtgccccgacccaaccaggtgagcgggcccgtcatgcccagcatgcctccc gggcagtggcagcaggcgccccttccccagcagcagcccatgccaggcttgcccaggcct gtgatatccatgcaggcccaggcggccgtggctgggccccggatgcccagcgtgcagcca cccaggagcatctcacccagcgctctgcaagacctgctgcggaccctgaagtcgcccagc tcccctcagcagcaacagcaggtgctgaacattctcaaatcaaacccgcagctaatggca gctttcatcaaacagcgcacagccaagtacgtggccaatcagcccggcatgcagccccag cctggcctccagtcccagcccggcatgcaaccccagcctggcatgcaccagcagcccagc ctgcagaacctgaatgccatgcaggctggcgtgccgcggcccggtgtgcctccacagcag caggcgatgggaggcctgaacccccagggccaggccttgaacatcatgaacccaggacac aaccccaacatggcgagtatgaatccacagtaccgagaaatgttacggaggcagctgctg cagcagcagcagcaacagcagcagcaacaacagcagcaacagcagcagcagcaagggagt gccggcatggctgggggcatggcggggcacggccagttccagcagcctcaaggacccgga ggctacccaccggccatgcagcagcagcagcgcatgcagcagcatctccccctccagggc agctccatgggccagatggcggctcagatgggacagcttggccagatggggcagccgggg ctgggggcagacagcacccccaacatccagcaagccctgcagcagcggattctgcagcaa cagcagatgaagcagcagattgggtccccaggccagccgaaccccatgagcccccagcaa cacatgctctcaggacagccacaggcctcgcatctccctggccagcagatcgccacgtcc cttagtaaccaggtgcggtctccagcccctgtccagtctccacggccccagtcccagcct ccacattccagcccgtcaccacggatacagccccagccttcgccacaccacgtctcaccc cagactggttccccccaccccggactcgcagtcaccatggccagctccatagatcaggga cacttggggaaccccgaacagagtgcaatgctcccccagctgaacacccccagcaggagt gcgctgtccagcgaactgtccctggtcggggacaccacgggggacacgctagagaagttt gtggagggcttgtag |
Protein Sequence |
>1387 : length: 2404 MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLV PDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGK SPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNAN FNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLA ETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASK QSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVL LLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIG SVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQM RTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIP TAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEG DMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQA QPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGS VPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTG VSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMT PPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPS VATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMK TETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVE VKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQ LLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC SKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCE KCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHY DIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYG SDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSE GDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELP YFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKS SISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSC DLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRW HCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQS LVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKC PVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPS TPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEA ARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPP GQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPS SPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPS LQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLL QQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQG SSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQ HMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSP QTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKF VEGL |