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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1387 |
Name | CREBBP |
Synonymous | CBP|KAT3A|RSTS;CREB binding protein;CREBBP;CREB binding protein |
Definition | CREB-binding protein |
Position | 16p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
beta-catenin(x) + CBP(h) <==> beta-catenin(x):CBP(h) (binding) | hipk2(h) + CBP(h) <==> hipk2(h):CBP(h) (binding) | CREB(h) + CBP(h) <==> CREB(h):CBP(h) (binding). | CBP(h) + TIF2(h) <==> CBP(h):TIF2(h) (binding). | ZAC-1b(m) + CBP(h) <==> ZAC-1b(m):CBP(h) (binding). | CBP(h) + HNF-4(h) <==> CBP(h):HNF-4(h) (binding) | PPARgamma1(h) + CBP(h) <==> PPARgamma1(h):CBP(h) (binding) | PPARdelta(h) + CBP(h) <==> PPARdelta(h):CBP(h) (binding) | CBP(h) + c-Jun(h) <==> CBP(h):c-Jun(h) (binding). | CBP(h) + RelA-p65(h) <==> CBP(h):RelA-p65(h) (binding). | CBP(h) + STAT2(h) <==> CBP(h):STAT2(h) (binding). | CBP(h) + JunB(h) <==> CBP(h):JunB(h) (binding). | PPARgamma(h) + CBP(h) <==> PPARgamma(h):CBP(h) (binding). | TRIF(h) + CBP(h) <==> TRIF(h):CBP(h) (binding) | TRAM(h) + CBP(h) <==> TRAM(h):CBP(h) (binding) | NF-AT1(h) + CBP(h) <==> NF-AT1(h):CBP(h) (assembly; binding; interaction) | IRF-3(h) + CBP(h) <==> IRF-3(h):CBP(h) (binding) | huntingtin(h) + CBP(h) <==> huntingtin(h):CBP(h) (binding) | p73alpha(mo) + CBP(h) <==> p73alpha(mo):CBP(h) (binding) | p73beta(mo) + CBP(h) <==> p73beta(mo):CBP(h) (binding) | CBP(h) + STAT5A(m){glyT92} <==> CBP(h):STAT5A(m){glyT92} (binding) | c-Ets-2(h) + CBP(h) <==> c-Ets-2(h):CBP(h) (binding) | CBP(h) --> TERT(h) (transactivation) | CBP(h) + HNF-1alpha(h) <==> CBP(h):HNF-1alpha(h) (binding) | CREBBP(h) --> CBP(h) (expression). | HNF-4(h) + acetyl-CoA --CBP(h)--> HNF-4(h){ace} + CoA (acetylation) | Sp3(h) + acetyl-CoA --CBP(h)--> Sp3(h){ace} + CoA (acetylation) | foxo4(h) + acetyl-CoA --CBP(h)--> foxo4(h){ace} + CoA (acetylation) | PARP(h) + 5 acetyl-CoA --CBP(h)--> PARP(h){aceK498}{aceK505}{aceK508}{aceK521}{aceK524} + 5 CoA (acetylation) | RSK1(h) + CBP(h) <==> RSK1(h):CBP(h) (binding) | CBP(h) + fgfr1(v.s.) <==> CBP(h):fgfr1(v.s.) (binding) | ASC-2(h) + CBP(h) <==> ASC-2(h):CBP(h) (binding) | Daxx(h) + CBP(h) + Pax-5(h) <==> Daxx(h):CBP(h):Pax-5(h) (binding) | CBP(h) + Daxx(h) <==> CBP(h):Daxx(h) (binding) | CBP(h) + c-Myc(h) <==> CBP(h):c-Myc(h) (binding) | Max(h) + CBP(h) <==> Max(h):CBP(h) (binding) | Ro52(h) + IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CBP(h) + TIF2(h) + SRC3(h) <==> Ro52(h):IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CBP(h):TIF2(h):SRC3(h) (binding) | Ro52(h) + CBP(h) + TIF2(h) + SRC-1(h) <==> Ro52(h):CBP(h):TIF2(h):SRC-1(h) (binding) | IKK-gamma(h) + IKK-beta(h) + CBP(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):CBP(h):SRC3(h) (binding) | Ku70(h) + CBP(h) <==> Ku70(h):CBP(h) (binding) | CBP(h) --> CBP(h) (translocation) | CBP(h) + FOXO1A(h) <==> CBP(h):FOXO1A(h) (binding) | c-Ets-1(m){pT38} + CBP(h) <==> c-Ets-1(m){pT38}:CBP(h) (binding) | CBP(h) + c-Ets-2(m){pT72} <==> CBP(h):c-Ets-2(m){pT72} (binding) | CBP(h) + sumo1(h) --> CBP(h){sumo} (sumoylation) | CBP(h) + COE1-long(m) <==> CBP(h):COE1-long(m) (binding) | CBP(h) + HOXB6(h) <==> CBP(h):HOXB6(h) (binding) | ASC-2(h) + DRIP205(h) + p300(h) + CBP(h) + NCOA6IP(m.s.) <==> ASC-2(h):DRIP205(h):p300(h):CBP(h):NCOA6IP(m.s.) (binding) | p/CAF(h) + CBP(h) + p300(h) + E2A(h) <==> p/CAF(h):CBP(h):p300(h):E2A(h) (binding) | E2A(h) + CBP(h) <==> E2A(h):CBP(h) (binding) | CBP(h) + GCMa(h) <==> CBP(h):GCMa(h) (binding) | APC5(h) + CBP(h) <==> APC5(h):CBP(h) (binding) | CBP(h) + APC7(h) <==> CBP(h):APC7(h) (binding) | Cdc20(h) + CBP(h) <==> Cdc20(h):CBP(h) (binding) | Fzr1(h) + CBP(h) <==> Fzr1(h):CBP(h) (binding) | CBP(h) --/ cyclinB1(h) (decrease of abundance) | CBP(h) --/ plk1(h) (decrease of abundance) | Smad1(m.s.) + CBP(h) <==> Smad1(m.s.):CBP(h) (binding) | Smad2(m.s.) + CBP(h) <==> Smad2(m.s.):CBP(h) (binding) | CBP(h) + ATP --> CBP(h){p} + ADP (phosphorylation) | CBP(h) + TDG(h) <==> CBP(h):TDG(h) (binding) | CBP(h) + SET-isoform2(m.s.) <==> CBP(h):SET-isoform2(m.s.) (binding) | CBP(h) + CREB1(h) <==> CBP(h):CREB1(h) (binding) | CBP(h) + CREM(h) <==> CBP(h):CREM(h) (binding) | CBP(h) + ATF-2(h) <==> CBP(h):ATF-2(h) (binding) | CBP(h) + p300(h) <==> CBP(h):p300(h) (binding) | CBP(h) + AML1(h) <==> CBP(h):AML1(h) (binding) | RelA-p65(h) + CBP(h) <==> RelA-p65(h):CBP(h) (binding) | p53(h) + CBP(h) <==> p53(h):CBP(h) (binding) | CBP(h) + IKK-alpha(h) <==> CBP(h):IKK-alpha(h) (binding) | CBP(h) + 2 ATP --IKK-alpha(h)--> CBP(h){pS1382}{pS1386} + 2 ADP (phosphorylation) | CBP(h) --> protein remnants (degradation) | brca1(h) + CBP(h) <==> brca1(h):CBP(h) (binding) | ER-alpha(h) + CBP(h) <==> ER-alpha(h):CBP(h) (binding) | NR1B1(h) + CBP(h) <==> NR1B1(h):CBP(h) (binding) | brca1(m.s.) + CBP(h) <==> brca1(m.s.):CBP(h) (binding) | CBP(h) + ER-alpha(m.s.) <==> CBP(h):ER-alpha(m.s.) (binding) | CBP(h) + Nrf2(m) <==> CBP(h):Nrf2(m) (binding) | CBP(h) + MNAR-isoform1(h) <==> CBP(h):MNAR-isoform1(h) (binding) | CBP(h) + IRF-3(h) <==> CBP(h):IRF-3(h) (binding) | c-Jun(h) + CBP(h) <==> CBP(h):c-Jun(h) (binding) | CBP(h) + ING1(h) <==> CBP(h):ING1(h) (binding) | CBP(h) + ING1a(h) <==> CBP(h):ING1a(h) (binding) | CBP(h) + ING1b(h) <==> CBP(h):ING1b(h) (binding) | CBP(h) + IFNAR2(h) <==> CBP(h):IFNAR2(h) (binding) | AKT(h) + CBP(h) <==> AKT(h):CBP(h) (binding) | CBP(h) + RelA-p65(h) <==> CBP(h):RelA-p65(h) (binding) | MSH2(h) + CBP(h) <==> MSH2(h):CBP(h) (binding) | GTBP(h) + CBP(h) <==> GTBP(h):CBP(h) (binding) | zbtb2(h) + CBP(h) <==> zbtb2(h):CBP(h) (binding) | ZASC1(h) + CBP(h) <==> ZASC1(h):CBP(h) (binding) | CREBBP(h) --> CBP(h) (expression). | CBP(h) --> CBP(h) (translocation) | PARP(h) + acetyl-CoA --CBP(h)--> PARP(h){aceK} + CoA (acetylation) | IFNAR2-isoform1(h) + acetyl-CoA --CBP(h)--> IFNAR2-isoform1(h){aceK399} + CoA (acetylation) | IRF-9(h) + acetyl-CoA --CBP(h)--> IRF-9(h){aceK} + CoA (acetylation) | STAT2(h) + acetyl-CoA --CBP(h)--> STAT2(h){aceK} + CoA (acetylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
601 | Omega-N-methylated arginine (Bysimilarity). | Swiss-Prot 53.0 | 625 | Omega-N-methylated arginine (Bysimilarity). | Swiss-Prot 53.0 | 1588 | N6-acetyllysine. | Swiss-Prot 53.0 | 1591 | N6-acetyllysine. | Swiss-Prot 53.0 | 1592 | N6-acetyllysine. | Swiss-Prot 53.0 | 1595 | N6-acetyllysine. | Swiss-Prot 53.0 | 1597 | N6-acetyllysine. | Swiss-Prot 53.0 | 2063 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 302 | Phosphoserine (CaM-KIV) | 11970865 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr16 |
Promoter: 3869622 - 3871622 | Agilent_014791 |
chr16 |
Promoter: 3869622 - 3871622 | GoldenGate_Methylation_Cancer_Panel_I |
chr16 |
Promoter: 3869622 - 3871622 | GoldenGate_Methylation_Cancer_Panel_I |
chr16 |
Promoter: 3869622 - 3871622 | GSE27584 |
chr16 |
Promoter: 3869622 - 3871622 | GSE27584 |
chr16 |
Promoter: 3869622 - 3871622 | Agilent_014791_44K |
chr16 |
Promoter: 3869622 - 3871622 | Agilent_014791 |