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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1490 |
Name | CTGF |
Synonym | CCN2|HCS24|IGFBP8|NOV2;connective tissue growth factor;CTGF;connective tissue growth factor |
Definition | CCN family member 2|IBP-8|IGF-binding protein 8|IGFBP-8|hypertrophic chondrocyte-specific protein 24|insulin-like growth factor-binding protein 8 |
Position | 6q23.1 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. |
potential | "CTGF may behave as a secreted tumor suppressor protein in the normal lung, and its expression is suppressed in many NSCLCs." |
| More detail of all 2 literatures about CTGF | |
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Pathways and Diseases |
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Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Scleroderma;FunDO |
Disease | Muscular dystrophies;FunDO |
Disease | Lung cancer;FunDO |
Disease | Biliary Atresia;FunDO |
Disease | Osteosarcoma;FunDO |
Disease | Liver cancer;FunDO |
Disease | Stomach cancer;FunDO |
Disease | Breast cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Embryoma;FunDO |
Disease | Gallbaldder cancer;FunDO |
Disease | Chronic rejection of renal transplant;FunDO |
Disease | Systemic scleroderma;FunDO |
Disease | Liver disease;FunDO |
Disease | Pancreas cancer;FunDO |
Disease | Kidney disease;FunDO |
Disease | Drug abuse;FunDO |
Disease | Fibroid tumor;FunDO |
Disease | Proteinuria;FunDO |
Disease | Malaria;FunDO |
Disease | Brain tumor;FunDO |
Disease | Hypertension;FunDO |
Disease | Squamous cell cancer;FunDO |
Disease | Gouts;FunDO |
Disease | IGA glomerulonephritis;FunDO |
Disease | Metastasis to lymph nodes;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Congenital abnormality;FunDO |
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External Links |
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Links to Entrez Gene | 1490 |
Links to all GeneRIF Items | 1490 |
Links to iHOP | 1490 |
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Sequence Information |
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Nucleotide Sequence |
>1490 : length: 1050 atgaccgccgccagtatgggccccgtccgcgtcgccttcgtggtcctcctcgccctctgc agccggccggccgtcggccagaactgcagcgggccgtgccggtgcccggacgagccggcg ccgcgctgcccggcgggcgtgagcctcgtgctggacggctgcggctgctgccgcgtctgc gccaagcagctgggcgagctgtgcaccgagcgcgacccctgcgacccgcacaagggcctc ttctgtgacttcggctccccggccaaccgcaagatcggcgtgtgcaccgccaaagatggt gctccctgcatcttcggtggtacggtgtaccgcagcggagagtccttccagagcagctgc aagtaccagtgcacgtgcctggacggggcggtgggctgcatgcccctgtgcagcatggac gttcgtctgcccagccctgactgccccttcccgaggagggtcaagctgcccgggaaatgc tgcgaggagtgggtgtgtgacgagcccaaggaccaaaccgtggttgggcctgccctcgcg gcttaccgactggaagacacgtttggcccagacccaactatgattagagccaactgcctg gtccagaccacagagtggagcgcctgttccaagacctgtgggatgggcatctccacccgg gttaccaatgacaacgcctcctgcaggctagagaagcagagccgcctgtgcatggtcagg ccttgcgaagctgacctggaagagaacattaagaagggcaaaaagtgcatccgtactccc aaaatctccaagcctatcaagtttgagctttctggctgcaccagcatgaagacataccga gctaaattctgtggagtatgtaccgacggccgatgctgcaccccccacagaaccaccacc ctgccggtggagttcaagtgccctgacggcgaggtcatgaagaagaacatgatgttcatc aagacctgtgcctgccattacaactgtcccggagacaatgacatctttgaatcgctgtac tacaggaagatgtacggagacatggcatga |
Protein Sequence |
>1490 : length: 349 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC AKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA |