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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1654 |
Name | DDX3X |
Synonym | DBX|DDX14|DDX3|HLP2;DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked;DDX3X;DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked |
Definition | ATP-dependent RNA helicase DDX3X|CAP-Rf|DEAD box protein 3, X-chromosomal|DEAD box, X isoform|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3|DEAD/H box-3|helicase like protein 2|helicase-like protein 2 |
Position | Xp11.3-p11.23 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein. |
potential | "DDX3 suppresses tumor growth and transcriptionally activates the p21 promoter, and is inactivated through down-regulation of gene expression or alteration of subcellular localization in tumor cells; DDX3 might be a candidate tumor suppressor." |
| More detail of all 2 literatures about DDX3X | |
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Pathways and Diseases |
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Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
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External Links |
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Links to Entrez Gene | 1654 |
Links to all GeneRIF Items | 1654 |
Links to iHOP | 1654 |
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Sequence Information |
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Nucleotide Sequence |
>1654 : length: 1986 atgagtcatgtggcagtggaaaatgcgctcgggctggaccagcagtttgctggcctagac ctgaactcttcagataatcagagtggaggaagtacagccagcaaagggcgctatattcct cctcatttaaggaaccgagaagctactaaaggtttctacgataaagacagttcagggtgg agttctagcaaagataaggatgcgtatagcagttttggatctcgtagtgattcaagaggg aagtctagcttcttcagtgatcgtggaagtggatcaaggggaaggtttgatgatcgtgga cggagtgattacgatggcattggcagccgtggtgacagaagtggctttggcaaatttgaa cgtggtggaaacagtcgctggtgtgacaaatcagatgaagatgattggtcaaaaccactc ccaccaagtgaacgcttggaacaggaactcttttctggaggcaacactgggattaatttt gagaaatacgatgacattccagttgaggcaacaggcaacaactgtcctccacatattgaa agtttcagtgatgttgagatgggagaaattatcatgggaaacattgagcttactcgttat actcgcccaactccagtgcaaaagcatgctattcctattatcaaagagaaaagagacttg atggcttgtgcccaaacagggtctggaaaaactgcagcatttctgttgcccatcttgagt cagatttattcagatggtccaggcgaggctttgagggccatgaaggaaaatggaaggtat gggcgccgcaaacaatacccaatctccttggtattagcaccaacgagagagttggcagta cagatctacgaggaagccagaaaattttcataccgatctagagttcgtccttgcgtggtt tatggtggtgccgatattggtcagcagattcgagacttggaacgtggatgccatttgtta gtagccactccaggacgtctagtggatatgatggaaagaggaaagattggattagacttt tgcaaatacttggtgttagatgaagctgatcggatgttggatatggggtttgagcctcag attcgtagaatagtcgaacaagatactatgcctccaaagggtgtccgccacactatgatg tttagtgctacttttcctaaggaaatacagatgctggctcgtgatttcttagatgaatat atcttcttggctgtaggaagagttggctctacctctgaaaacatcacacagaaagtagtt tgggtggaagaatcagacaaacggtcatttctgcttgacctcctaaatgcaacaggcaag gattcactgaccttagtgtttgtggagaccaaaaagggtgcagattctctggaggatttc ttataccatgaaggatacgcatgtaccagcatccatggagaccgttctcagagggataga gaagaggcccttcaccagttccgctcaggaaaaagcccaattttagtggctacagcagta gcagcaagaggactggacatttcaaatgtgaaacatgttatcaattttgacttgccaagt gatattgaagaatatgtacatcgtattggtcgtacgggacgtgtaggaaaccttggcctg gcaacctcattctttaacgagaggaacataaatattactaaggatttgttggatcttctt gttgaagctaaacaagaagtgccgtcttggttagaaaacatggcttatgaacaccactac aagggtagcagtcgtggacgttctaagagcagatttagtggagggtttggtgccagagac taccgacaaagtagcggtgccagcagttccagcttcagcagcagccgcgcaagcagcagc cgcagtggcggaggtggccacggtagcagcagaggatttggtggaggtggctatggaggc ttttacaacagtgatggatatggaggaaattataactcccagggggttgactggtggggt aactga |
Protein Sequence |
>1654 : length: 661 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARD YRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWG N |