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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1796 |
Name | DOK1 |
Synonym | P62DOK;docking protein 1, 62kDa (downstream of tyrosine kinase 1);DOK1;docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Definition | Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62 |
Position | 2p13 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Identification of DOK genes as lung tumor suppressors. |
reviewed | These data suggest a mechanistic basis for the inhibitory effect of Dok-1 on growth factor-induced mitogenesis and its role as a tumor suppressor. |
| More detail of all 2 literatures about DOK1 | |
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Pathways and Diseases |
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Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
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External Links |
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Links to Entrez Gene | 1796 |
Links to all GeneRIF Items | 1796 |
Links to iHOP | 1796 |
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Sequence Information |
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Nucleotide Sequence |
>1796 : length: 1029 atgctggagaactccttgtacagccctacctgggaaggatcccaattctgggtaacggtg cagaggactgaggccgccgagcgctgtggcctgcatggctcctacgtgctgagggtggag gctgaaaggctgactctcctgaccgtgggggcccagagtcagatactggagccactcctg tcctggccctacactctgttgcgtcgctatggccgggacaaggtcatgttctctttcgag gccggccgccgctgcccctcaggccctggaaccttcaccttccagacggcacagggaaat gacatcttccaggcagttgagactgccatccaccggcagaaggcccagggaaaggccgga caggggcacgatgttctcagagctgactcccatgaaggggaggtggcagaggggaagttg ccttccccacctggcccccaagagctcctcgacagtcccccagccctgtatgctgagccc ttagactccctgcgcattgctccatgcccttcccaggactccctatactcagaccccttg gacagcacgtctgctcaggcaggagagggagtacaacggaagaaacctctctattgggac ttgtatgagcatgcgcagcagcagttgctgaaggccaagctgacagaccccaaagaggat cccatctatgatgaacctgagggcctggccccagtccctccccagggcctttatgatctg cctcgggagcccaaggatgcatggtggtgccaagctcgggtgaaggaggagggctatgag ctcccctacaaccctgccactgatgactacgctgtgccaccccctcggagcacaaagccc ctccttgctcccaagccccagggcccagccttccctgaacctggtactgcaactggcagt ggcatcaaaagccacaactcagccctgtacagccaggtccagaagagcggggcctcaggg agctgggactgtgggctctctagagtagggactgacaagactggggtcaagtcagagggc tctacctga |
Protein Sequence |
>1796 : length: 342 MLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLL SWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAG QGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPL DSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDL PREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGS GIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST |