Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

1796

Name

DOK1

Synonymous

P62DOK;docking protein 1, 62kDa (downstream of tyrosine kinase 1);DOK1;docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Definition

Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62

Position

2p13

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

p62Dok-1(h) + ATP --Lyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation)
p62Dok-1(h) + ATP --tec(h)--> p62Dok-1(h){pY} + ADP (phosphorylation)
p62Dok-1(h) + ATP --Fyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation)
p62Dok-1(h) + ATP --> p62Dok-1(h){pY} + ADP (phosphorylation)
RasGAP(h) + p62Dok-1(h) <==> RasGAP(h):p62Dok-1(h) (binding)
NCK(h) + p62Dok-1(h) <==> NCK(h):p62Dok-1(h) (binding)
ErbB2(h){pY1221}{pY1222} + p62Dok-1(h) <==> ErbB2(h){pY1221}{pY1222}:p62Dok-1(h) (binding)
SHIP(h){pY} + p56Dok-2(h) + p62Dok-1(h) <==> SHIP(h){pY}:p56Dok-2(h):p62Dok-1(h) (binding)
DOK1(h) --> p62Dok-1(h) (expression).
DOK1(h) --> p62Dok1-isoform1(h) (expression).
DOK1(h) --> p62Dok1-isoform2(h) (expression).
DOK1(h) --> p62Dok-1-isoform3(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

269Phosphoserine.Swiss-Prot 53.0
296Phosphotyrosine (By similarity).Swiss-Prot 53.0
315Phosphotyrosine (By similarity).Swiss-Prot 53.0
337Phosphotyrosine (By similarity).Swiss-Prot 53.0
341Phosphotyrosine (By similarity).Swiss-Prot 53.0
362Phosphotyrosine (by INSR).Swiss-Prot 53.0
377Phosphotyrosine.Swiss-Prot 53.0
398Phosphotyrosine (by INSR).Swiss-Prot 53.0
402Phosphotyrosine.Swiss-Prot 53.0
409Phosphotyrosine.Swiss-Prot 53.0
449Phosphotyrosine.Swiss-Prot 53.0
146Phosphotyrosine11042170Phospho.ELM 6.0
362Phosphotyrosine (InsR)12087092;11551902;10688886;15592455;16094384Phospho.ELM 6.0
341Phosphotyrosine12087092Phospho.ELM 6.0
296Phosphotyrosine12087092;10688886Phospho.ELM 6.0
315Phosphotyrosine12087092;10688886Phospho.ELM 6.0
377Phosphotyrosine12087092;10688886;15592455;16094384Phospho.ELM 6.0
409Phosphotyrosine12087092;10688886;15592455;16094384Phospho.ELM 6.0
449Phosphotyrosine12087092;10852966;12522270;15592455;16094384;15659Phospho.ELM 6.0
398Phosphotyrosine (InsR)12087092;11551902;10688886;15592455;16094384Phospho.ELM 6.0
402Phosphotyrosine15592455Phospho.ELM 6.0
203Phosphotyrosine12087092Phospho.ELM 6.0
439Phosphoserine15574499Phospho.ELM 6.0
446Phosphoserine15574499Phospho.ELM 6.0
450Phosphoserine15574499Phospho.ELM 6.0
269Phosphoserine16094384Phospho.ELM 6.0
337Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr2

Promoter: 74633868 - 74635868GSE27584

chr2

Promoter: 74633868 - 74635868Agilent_014791_44K


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