|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1796 |
Name | DOK1 |
Synonymous | P62DOK;docking protein 1, 62kDa (downstream of tyrosine kinase 1);DOK1;docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Definition | Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62 |
Position | 2p13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
|
Regulation From TransFac database |
p62Dok-1(h) + ATP --Lyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation) | p62Dok-1(h) + ATP --tec(h)--> p62Dok-1(h){pY} + ADP (phosphorylation) | p62Dok-1(h) + ATP --Fyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation) | p62Dok-1(h) + ATP --> p62Dok-1(h){pY} + ADP (phosphorylation) | RasGAP(h) + p62Dok-1(h) <==> RasGAP(h):p62Dok-1(h) (binding) | NCK(h) + p62Dok-1(h) <==> NCK(h):p62Dok-1(h) (binding) | ErbB2(h){pY1221}{pY1222} + p62Dok-1(h) <==> ErbB2(h){pY1221}{pY1222}:p62Dok-1(h) (binding) | SHIP(h){pY} + p56Dok-2(h) + p62Dok-1(h) <==> SHIP(h){pY}:p56Dok-2(h):p62Dok-1(h) (binding) | DOK1(h) --> p62Dok-1(h) (expression). | DOK1(h) --> p62Dok1-isoform1(h) (expression). | DOK1(h) --> p62Dok1-isoform2(h) (expression). | DOK1(h) --> p62Dok-1-isoform3(h) (expression). |
|---|
Post Transcriptional Modification From dbPTM | | Top | |
|
Location (AA) |
PTM type |
Literature |
Database |
269 | Phosphoserine. | Swiss-Prot 53.0 | 296 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 315 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 337 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 341 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 362 | Phosphotyrosine (by INSR). | Swiss-Prot 53.0 | 377 | Phosphotyrosine. | Swiss-Prot 53.0 | 398 | Phosphotyrosine (by INSR). | Swiss-Prot 53.0 | 402 | Phosphotyrosine. | Swiss-Prot 53.0 | 409 | Phosphotyrosine. | Swiss-Prot 53.0 | 449 | Phosphotyrosine. | Swiss-Prot 53.0 | 146 | Phosphotyrosine | 11042170 | Phospho.ELM 6.0 | 362 | Phosphotyrosine (InsR) | 12087092;11551902;10688886;15592455;16094384 | Phospho.ELM 6.0 | 341 | Phosphotyrosine | 12087092 | Phospho.ELM 6.0 | 296 | Phosphotyrosine | 12087092;10688886 | Phospho.ELM 6.0 | 315 | Phosphotyrosine | 12087092;10688886 | Phospho.ELM 6.0 | 377 | Phosphotyrosine | 12087092;10688886;15592455;16094384 | Phospho.ELM 6.0 | 409 | Phosphotyrosine | 12087092;10688886;15592455;16094384 | Phospho.ELM 6.0 | 449 | Phosphotyrosine | 12087092;10852966;12522270;15592455;16094384;15659 | Phospho.ELM 6.0 | 398 | Phosphotyrosine (InsR) | 12087092;11551902;10688886;15592455;16094384 | Phospho.ELM 6.0 | 402 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 203 | Phosphotyrosine | 12087092 | Phospho.ELM 6.0 | 439 | Phosphoserine | 15574499 | Phospho.ELM 6.0 | 446 | Phosphoserine | 15574499 | Phospho.ELM 6.0 | 450 | Phosphoserine | 15574499 | Phospho.ELM 6.0 | 269 | Phosphoserine | 16094384 | Phospho.ELM 6.0 | 337 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|
Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 74633868 - 74635868 | GSE27584 |
chr2 |
Promoter: 74633868 - 74635868 | Agilent_014791_44K |