Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2100

Name

ESR2

Synonym

ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2;estrogen receptor 2 (ER beta);ESR2;estrogen receptor 2 (ER beta)

Definition

estrogen nuclear receptor beta variant a|estrogen nuclear receptor beta variant b|estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2

Position

14q23.2

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

reviewed

"Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary gland".

potential

ERbeta acting as a tumor suppressor is of high potential relevance to prediction of disease progression.

reviewed

ERbeta exerts antiproliferative effects both on MCF-10A and MCF-7 cells in a ligand- and ERalpha-independent manner by regulation of p21/WAF or cyclin A2 gene expression. ERbeta acts as a tumor suppressor in mammary epithelium.
More detail of all 3 literatures about ESR2

Pathways and Diseases

Pathway

Gene Expression;Reactome;REACT:71

Pathway

Plasma membrane estrogen receptor signaling;PID Curated;200029

Disease

bulimia;GAD

Disease

endometriosis;GAD

Disease

Myasthenia Gravis;FunDO

Disease

homocysteine nitric oxide;GAD

Disease

Cancer;FunDO

Disease

Cholelithiasis;FunDO

Disease

Parkinson disease;FunDO

Disease

Glaucoma;FunDO

Disease

Infertility, Male;GAD

Disease

bone density fracture risk osteoporosis, postmenopausal;GAD

Disease

Parkinson's disease;GAD

Disease

prostate cancer;GAD

Disease

Dental plaque;FunDO

Disease

Ptosis;FunDO

Disease

Schizophrenia;FunDO

Disease

Alzheimer's disease;FunDO

Disease

bone density fractures, vertebral;GAD

Disease

Bone Mineral Density;GAD

Disease

METABOLIC;GAD

Disease

bone density;GAD

Disease

PSYCH;GAD

Disease

Ovarian disease;FunDO

Disease

REPRODUCTION;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Late pregnancy;FunDO

Disease

Testicular dysfunction;FunDO

Disease

blood pressure;GAD

Disease

hypospadias;GAD

Disease

Endometriosis;FunDO

Disease

NEUROLOGICAL;GAD

Disease

Hypertension;FunDO

Disease

blood pressure, arterial;GAD

Disease

bone mass;GAD

Disease

hormone disturbance;GAD

Disease

Osteoporosis;FunDO

Disease

breast cancer;GAD

Disease

CANCER;GAD

Disease

menstrual disorders;GAD

Disease

cholesterol cholesterol, HDL cholesterol, LDL fatty acid glucose insulin lipoprotein triacylglycerols;GAD

Disease

Temporal arteritis;FunDO

Disease

dementia, vascular;GAD

Disease

Atherosclerosis;FunDO

External Links

Links to Entrez Gene

2100

Links to all GeneRIF Items

2100

Links to iHOP

2100

Sequence Information

Nucleotide Sequence

>2100 : length: 1488
atggatataaaaaactcaccatctagccttaattctccttcctcctacaactgcagtcaa
tccatcttacccctggagcacggctccatatacataccttcctcctatgtagacagccac
catgaatatccagccatgacattctatagccctgctgtgatgaattacagcattcccagc
aatgtcactaacttggaaggtgggcctggtcggcagaccacaagcccaaatgtgttgtgg
ccaacacctgggcacctttctcctttagtggtccatcgccagttatcacatctgtatgcg
gaacctcaaaagagtccctggtgtgaagcaagatcgctagaacacaccttacctgtaaac
agagagacactgaaaaggaaggttagtgggaaccgttgcgccagccctgttactggtcca
ggttcaaagagggatgctcacttctgcgctgtctgcagcgattacgcatcgggatatcac
tatggagtctggtcgtgtgaaggatgtaaggccttttttaaaagaagcattcaaggacat
aatgattatatttgtccagctacaaatcagtgtacaatcgataaaaaccggcgcaagagc
tgccaggcctgccgacttcggaagtgttacgaagtgggaatggtgaagtgtggctcccgg
agagagagatgtgggtaccgccttgtgcggagacagagaagtgccgacgagcagctgcac
tgtgccggcaaggccaagagaagtggcggccacgcgccccgagtgcgggagctgctgctg
gacgccctgagccccgagcagctagtgctcaccctcctggaggctgagccgccccatgtg
ctgatcagccgccccagtgcgcccttcaccgaggcctccatgatgatgtccctgaccaag
ttggccgacaaggagttggtacacatgatcagctgggccaagaagattcccggctttgtg
gagctcagcctgttcgaccaagtgcggctcttggagagctgttggatggaggtgttaatg
atggggctgatgtggcgctcaattgaccaccccggcaagctcatctttgctccagatctt
gttctggacagggatgaggggaaatgcgtagaaggaattctggaaatctttgacatgctc
ctggcaactacttcaaggtttcgagagttaaaactccaacacaaagaatatctctgtgtc
aaggccatgatcctgctcaattccagtatgtaccctctggtcacagcgacccaggatgct
gacagcagccggaagctggctcacttgctgaacgccgtgaccgatgctttggtttgggtg
attgccaagagcggcatctcctcccagcagcaatccatgcgcctggctaacctcctgatg
ctcctgtcccacgtcaggcatgcgagggcagaaaaggcctctcaaacactcacctcattt
ggaatgaagatggagactcttttgcctgaagcaacgatggagcagtga

Protein Sequence

>2100 : length: 495
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARAEKASQTLTSF
GMKMETLLPEATMEQ



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