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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2100 |
Name | ESR2 |
Synonym | ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2;estrogen receptor 2 (ER beta);ESR2;estrogen receptor 2 (ER beta) |
Definition | estrogen nuclear receptor beta variant a|estrogen nuclear receptor beta variant b|estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2 |
Position | 14q23.2 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary gland". |
potential | ERbeta acting as a tumor suppressor is of high potential relevance to prediction of disease progression. |
reviewed | ERbeta exerts antiproliferative effects both on MCF-10A and MCF-7 cells in a ligand- and ERalpha-independent manner by regulation of p21/WAF or cyclin A2 gene expression. ERbeta acts as a tumor suppressor in mammary epithelium. |
| More detail of all 3 literatures about ESR2 | |
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Pathways and Diseases |
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Pathway | Gene Expression;Reactome;REACT:71 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Disease | bulimia;GAD |
Disease | endometriosis;GAD |
Disease | Myasthenia Gravis;FunDO |
Disease | homocysteine nitric oxide;GAD |
Disease | Cancer;FunDO |
Disease | Cholelithiasis;FunDO |
Disease | Parkinson disease;FunDO |
Disease | Glaucoma;FunDO |
Disease | Infertility, Male;GAD |
Disease | bone density fracture risk osteoporosis, postmenopausal;GAD |
Disease | Parkinson's disease;GAD |
Disease | prostate cancer;GAD |
Disease | Dental plaque;FunDO |
Disease | Ptosis;FunDO |
Disease | Schizophrenia;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | bone density fractures, vertebral;GAD |
Disease | Bone Mineral Density;GAD |
Disease | METABOLIC;GAD |
Disease | bone density;GAD |
Disease | PSYCH;GAD |
Disease | Ovarian disease;FunDO |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Late pregnancy;FunDO |
Disease | Testicular dysfunction;FunDO |
Disease | blood pressure;GAD |
Disease | hypospadias;GAD |
Disease | Endometriosis;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | Hypertension;FunDO |
Disease | blood pressure, arterial;GAD |
Disease | bone mass;GAD |
Disease | hormone disturbance;GAD |
Disease | Osteoporosis;FunDO |
Disease | breast cancer;GAD |
Disease | CANCER;GAD |
Disease | menstrual disorders;GAD |
Disease | cholesterol cholesterol, HDL cholesterol, LDL fatty acid glucose insulin lipoprotein triacylglycerols;GAD |
Disease | Temporal arteritis;FunDO |
Disease | dementia, vascular;GAD |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 2100 |
Links to all GeneRIF Items | 2100 |
Links to iHOP | 2100 |
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Sequence Information |
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Nucleotide Sequence |
>2100 : length: 1488 atggatataaaaaactcaccatctagccttaattctccttcctcctacaactgcagtcaa tccatcttacccctggagcacggctccatatacataccttcctcctatgtagacagccac catgaatatccagccatgacattctatagccctgctgtgatgaattacagcattcccagc aatgtcactaacttggaaggtgggcctggtcggcagaccacaagcccaaatgtgttgtgg ccaacacctgggcacctttctcctttagtggtccatcgccagttatcacatctgtatgcg gaacctcaaaagagtccctggtgtgaagcaagatcgctagaacacaccttacctgtaaac agagagacactgaaaaggaaggttagtgggaaccgttgcgccagccctgttactggtcca ggttcaaagagggatgctcacttctgcgctgtctgcagcgattacgcatcgggatatcac tatggagtctggtcgtgtgaaggatgtaaggccttttttaaaagaagcattcaaggacat aatgattatatttgtccagctacaaatcagtgtacaatcgataaaaaccggcgcaagagc tgccaggcctgccgacttcggaagtgttacgaagtgggaatggtgaagtgtggctcccgg agagagagatgtgggtaccgccttgtgcggagacagagaagtgccgacgagcagctgcac tgtgccggcaaggccaagagaagtggcggccacgcgccccgagtgcgggagctgctgctg gacgccctgagccccgagcagctagtgctcaccctcctggaggctgagccgccccatgtg ctgatcagccgccccagtgcgcccttcaccgaggcctccatgatgatgtccctgaccaag ttggccgacaaggagttggtacacatgatcagctgggccaagaagattcccggctttgtg gagctcagcctgttcgaccaagtgcggctcttggagagctgttggatggaggtgttaatg atggggctgatgtggcgctcaattgaccaccccggcaagctcatctttgctccagatctt gttctggacagggatgaggggaaatgcgtagaaggaattctggaaatctttgacatgctc ctggcaactacttcaaggtttcgagagttaaaactccaacacaaagaatatctctgtgtc aaggccatgatcctgctcaattccagtatgtaccctctggtcacagcgacccaggatgct gacagcagccggaagctggctcacttgctgaacgccgtgaccgatgctttggtttgggtg attgccaagagcggcatctcctcccagcagcaatccatgcgcctggctaacctcctgatg ctcctgtcccacgtcaggcatgcgagggcagaaaaggcctctcaaacactcacctcattt ggaatgaagatggagactcttttgcctgaagcaacgatggagcagtga |
Protein Sequence |
>2100 : length: 495 MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARAEKASQTLTSF GMKMETLLPEATMEQ |