Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2100

Name

ESR2

Synonymous

ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2;estrogen receptor 2 (ER beta);ESR2;estrogen receptor 2 (ER beta)

Definition

estrogen nuclear receptor beta variant a|estrogen nuclear receptor beta variant b|estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2

Position

14q23.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

ER-beta-isoform1(h) --> Vegfa(r) (DNA binding; transregulation).
ER-beta-isoform1(h) + ER-alpha(h) <==> ER-beta-isoform1(h):ER-alpha(h) (binding).
ER-beta-isoform1(h) + ER-beta-isoform1(h) <==> ER-beta-isoform1(h):ER-beta-isoform1(h) (binding).
ER-beta-isoform1(h) --> C3(h) (DNA binding).
ER-beta-isoform1(h) --> TFF1(h) (DNA binding).
ER-beta-isoform1(h) --> VIT-II(c) (DNA binding).
ER-beta-isoform1(h) --> CTSD(h) (DNA binding).
ER-beta-isoform1(h) --> NQO1(h) (DNA binding; transactivation).
ER-beta-isoform1(h) --> Jun(r) (DNA binding).
ER-beta-isoform1(h) --> Fos(m) (DNA binding).
ER-beta-isoform1(h) --> Chat(m) (DNA binding).
ER-beta-isoform1(h) + MSH-2(h) <==> ER-beta-isoform1(h):MSH-2(h) (binding)
ER-beta-isoform1(h) + SPF45(h) <==> ER-beta-isoform1(h):SPF45(h) (binding)
ESR2(h) --> ER-beta-isoform1(h) (expression).
ESR2(h) --> ER-beta-isoform2(h) (expression).
ESR2(h) --> ER-beta-isoform3(h) (expression).
ESR2(h) --> ER-beta-isoform4(h) (expression).
ESR2(h) --> ER-beta-isoform5(h) (expression).
ER-beta(h) + MRF1(h) <==> ER-beta(h):MRF1(h) (binding)
ER-beta(h) + RTA-isoform1(h) <==> ER-beta(h):RTA-isoform1(h) (binding)
BAF57(m) + ER-beta(h) <==> BAF57(m):ER-beta(h) (binding)
ER-beta(h) + estradiol <==> ER-beta(h):estradiol (binding)
ER-beta(h) + DP97-xbb2(h) <==> ER-beta(h):DP97-xbb2(h) (binding)
ER-beta(h) --> AR(h) (binding)
ER-beta(h) --> AR(h) (activation)
AKT-1(h) + ER-beta(h) <==> AKT-1(h):ER-beta(h) (binding)
AKT(h){pT308}{pS473} + ER-beta(h) <==> AKT(h){pT308}{pS473}:ER-beta(h) (binding)
GT198(r) + ER-beta(h) <==> GT198(r):ER-beta(h) (binding)
ER-beta(h) + COM1(h) <==> ER-beta(h):COM1(h) (binding)
ER-beta(h) + MNAR(h) <==> ER-beta(h):MNAR(h) (binding)
ER-beta(h) + MSH2(h) <==> ER-beta(h):MSH2(h) (binding)
14-3-3eta(h) + ER-beta(h) <==> 14-3-3eta(h):ER-beta(h) (binding)
ER-beta(h) + DAP3(h) <==> ER-beta(h):DAP3(h) (binding)
p300(m.s.) + ER-beta(h) <==> p300(m.s.):ER-beta(h) (binding)
ER-beta(h) + SRC-1(h) <==> ER-beta(h):SRC-1(h) (binding)
ER-beta(h) + TIF2(h) <==> ER-beta(h):TIF2(h) (binding)
ER-beta(h) + SRC3(h) <==> ER-beta(h):SRC3(h) (binding)
ER-beta(h) --> INSR(h) (DNA binding).
NCOR1-isoform1(m) + ER-beta(h) <==> NCOR1-isoform1(m):ER-beta(h) (binding)
ER-beta(h) --/ CRHBP(h) (DNA binding; transrepression).
ASC-2(m) + ER-beta(h) <==> ASC-2(m):ER-beta(h) (binding)
ER-beta(h) --> Avp(r) (DNA binding)
ER-beta(h) --> prl(h) (DNA binding).
Smad3(m.s.) + ER-beta(h) <==> Smad3(m.s.):ER-beta(h) (binding)
Smad2(m.s.) + ER-beta(h) <==> Smad2(m.s.):ER-beta(h) (binding)
Smad4(m.s.) + ER-beta(h) <==> Smad4(m.s.):ER-beta(h) (binding)
ER-beta(h) --> VEGFA(h) (transactivation)
ER-beta(h) + palmityl-CoA --> ER-beta(h){pal} + CoA (palmitoylation)
ER-beta(h) --> C3(h) (transactivation)
ER-beta(h) --> SSTR2(h) (DNA binding).
ER-beta(h) --> BMP2(m) (transactivation)
ER-beta(h) --/ TNF(h) (transrepression)
PNRC(h) + ER-beta(h) <==> PNRC(h):ER-beta(h) (binding)
ER-beta(h) + PNRC2(h) <==> ER-beta(h):PNRC2(h) (binding)
PGC-1(h) + ER-beta(h) <==> PGC-1(h):ER-beta(h) (binding)
ER-beta(h) + ASC-2(h) <==> ER-beta(h):ASC-2(h) (binding)
ER-beta(h) + RIP140(h) <==> ER-beta(h):RIP140(h) (binding)
ER-beta(h) --> OVGP1(h) (DNA binding).
ESR2(h) --> ER-beta(h) (expression).
Src(h) --> ER-beta(h) (binding)
AR(h) --> ER-beta(h) (activation)
ESR2(h) --> ER-beta-isoform6(h) (expression).
ESR2(h) --> ER-beta-isoform7(h) (expression).
ESR2(h) --> ER-beta-isoform8(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

87Phosphoserine (By similarity).Swiss-Prot 53.0
488Phosphotyrosine (By similarity).Swiss-Prot 53.0
165Phosphoserine (RSK-1)9528769Phospho.ELM 6.0
105Phosphoserine15862947Phospho.ELM 6.0
87Phosphoserine15862947Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr14

 Promoter: 63830381 - 63832381Agilent_014791

chr14

 Promoter: 63830381 - 63832381GoldenGate_Methylation_Cancer_Panel_I

chr14

 Promoter: 63830381 - 63832381GoldenGate_Methylation_Cancer_Panel_I

chr14

 Promoter: 63830381 - 63832381GSE27584

chr14

 Promoter: 63874521 - 63876521GSE27584

chr14

 Promoter: 63830381 - 63832381GSE27584

chr14

 Promoter: 63874521 - 63876521Agilent_014791_44K

chr14

 Promoter: 63830381 - 63832381PMID:15254780

chr14

 Promoter: 63874521 - 63876521PMID:15254780

chr14

 Promoter: 63830381 - 63832381PMID:15254780

chr14

 Promoter: 63830381 - 63832381PMID:16181550

chr14

 Promoter: 63874521 - 63876521PMID:16181550

chr14

 Promoter: 63830381 - 63832381PMID:16181550

chr14

 Promoter: 63830381 - 63832381PMID:15536519

chr14

 Promoter: 63874521 - 63876521PMID:15536519

chr14

 Promoter: 63830381 - 63832381PMID:15536519

chr14

 Promoter: 63830381 - 63832381PMID:15172987

chr14

 Promoter: 63874521 - 63876521PMID:15172987

chr14

 Promoter: 63830381 - 63832381PMID:15172987

chr14

 Promoter: 63830381 - 63832381PMID:16322330

chr14

 Promoter: 63874521 - 63876521PMID:16322330

chr14

 Promoter: 63830381 - 63832381PMID:16322330

chr14

 Promoter: 63830381 - 63832381PMID:16889486

chr14

 Promoter: 63874521 - 63876521PMID:16889486

chr14

 Promoter: 63830381 - 63832381PMID:16889486

chr14

 Promoter: 63830381 - 63832381PMID:11880477

chr14

 Promoter: 63874521 - 63876521PMID:11880477

chr14

 Promoter: 63830381 - 63832381PMID:11880477

chr14

 Promoter: 63830381 - 63832381PMID:15161636

chr14

 Promoter: 63874521 - 63876521PMID:15161636

chr14

 Promoter: 63830381 - 63832381PMID:15161636

chr14

 Promoter: 63830381 - 63832381PMID:11596023

chr14

 Promoter: 63874521 - 63876521PMID:11596023

chr14

 Promoter: 63830381 - 63832381PMID:11596023

chr14

 Promoter: 63830381 - 63832381PMID:11895880

chr14

 Promoter: 63874521 - 63876521PMID:11895880

chr14

 Promoter: 63830381 - 63832381PMID:11895880

chr14

 Promoter: 63830381 - 63832381PMID:15639718

chr14

 Promoter: 63874521 - 63876521PMID:15639718

chr14

 Promoter: 63830381 - 63832381PMID:15639718

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