Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

219699

Name

UNC5B

Synonym

UNC5H2|p53RDL1;unc-5 homolog B (C. elegans);UNC5B;unc-5 homolog B (C. elegans)

Definition

netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2

Position

10q22.1

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 2 PubMed records as below.

Evidence Status

Description

reviewed

"UNC5B acts as a tumor suppressor, and it induces apoptosis in the absence of its cognate ligand netrins. UNC5B is a direct transcriptional target of p53 upon UV stimulation."

potential

UNC5H may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis.
More detail of all 2 literatures about UNC5B

Pathways and Diseases

Pathway

Apoptosis;Reactome;REACT:578

Pathway

Axon guidance mediated by netrin;PANTHER;P00009

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

Netrin-1 signaling;PID Reactome;500088

Pathway

Axon guidance;KEGG PATHWAY;hsa04360

Pathway

Role of DCC in regulating apoptosis;PID Reactome;500280

Pathway

Netrin-mediated signaling;PID Curated;200074

Disease

PSYCH;GAD

Disease

attention-deficit hyperactivity disorder;GAD

Disease

Cancer;FunDO

Disease

ADHD;GAD

Disease

Attention deficit hyperactivity disorder;NHGRI

External Links

Links to Entrez Gene

219699

Links to all GeneRIF Items

219699

Links to iHOP

219699

Sequence Information

Nucleotide Sequence

>219699 : length: 2838
atgggggcccggagcggagctcggggcgcgctgctgctggcactgctgctctgctgggac
ccgaggctgagccaagcaggcactgattctggcagcgaggtgctccctgactccttcccg
tcagcgccagcagagccgctgccctacttcctgcaggagccacaggacgcctacattgtg
aagaacaagcctgtggagctccgctgccgcgccttccccgccacacagatctacttcaag
tgcaacggcgagtgggtcagccagaacgaccacgtcacacaggaaggcctggatgaggcc
accggcctgcgggtgcgcgaggtgcagatcgaggtgtcgcggcagcaggtggaggagctc
tttgggctggaggattactggtgccagtgcgtggcctggagctccgcgggcaccaccaag
agtcgccgagcctacgtccgcatcgcctacctgcgcaagaacttcgatcaggagcctctg
ggcaaggaggtgcccctggaccatgaggttctcctgcagtgccgcccgccggagggggtg
cctgtggccgaggtggaatggctcaagaatgaggatgtcatcgaccccacccaggacacc
aacttcctgctcaccatcgaccacaacctcatcatccgccaggcccgcctgtcggacact
gccaactatacctgcgtggccaagaacatcgtggccaaacgccggagcaccactgccacc
gtcatcgtctacgtgaatggcggctggtccagctgggcagagtggtcaccctgctccaac
cgctgtggccgaggctggcagaagcgcacccggacctgcaccaaccccgctccactcaac
ggaggggccttctgcgagggccaggcattccagaagaccgcctgcaccaccatctgccca
gtcgatggggcgtggacggagtggagcaagtggtcagcctgcagcactgagtgtgcccac
tggcgtagccgcgagtgcatggcgcccccaccccagaacggaggccgtgactgcagcggg
acgctgctcgactctaagaactgcacagatgggctgtgcatgcaaaataagaaaactcta
agcgaccccaacagccacctgctggaggcctcaggggatgcggcgctgtatgcggggctc
gtggtggccatcttcgtggtcgtggcaatcctcatggcggtgggggtggtggtgtaccgc
cgcaactgccgtgacttcgacacagacatcactgactcatctgctgccctgactggtggt
ttccaccccgtcaactttaagacggcaaggcccagcaacccgcagctcctacacccctct
gtgcctcctgacctgacagccagcgccggcatctaccgcggacccgtgtatgccctgcag
gactccaccgacaaaatccccatgaccaactctcctctgctggaccccttacccagcctt
aaggtcaaggtctacagctccagcaccacgggctctgggccaggcctggcagatggggct
gacctgctgggggtcttgccgcctggcacataccctagcgatttcgcccgggacacccac
ttcctgcacctgcgcagcgccagcctcggttcccagcagctcttgggcctgccccgagac
ccagggagcagcgtcagcggcacctttggctgcctgggtgggaggctcagcatccccggc
acaggggtcagcttgctggtgcccaatggagccattccccagggcaagttctacgagatg
tatctactcatcaacaaggcagaaagtaccctcccgctttcagaagggacccagacagta
ttgagcccctcggtgacctgtggacccacaggcctcctgctgtgccgccccgtcatcctc
accatgccccactgtgccgaagtcagtgcccgtgactggatctttcagctcaagacccag
gcccaccagggccactgggaggaggtggtgaccctggatgaggagaccctgaacacaccc
tgctactgccagctggagcccagggcctgtcacatcctgctggaccagctgggcacctac
gtgttcacgggcgagtcctattcccgctcagcagtcaagcggctccagctggccgtcttc
gcccccgccctctgcacctccctggagtacagcctccgggtctactgcctggaggacacg
cctgtagcactgaaggaggtgctggagctggagcggactctgggcggatacttggtggag
gagccgaaaccgctaatgttcaaggacagttaccacaacctgcgcctctccctccatgac
ctcccccatgcccattggaggagcaagctgctggccaaataccaggagatccccttctat
cacatttggagtggcagccagaaggccctccactgcactttcaccctggagaggcacagc
ttggcctccacagagctcacctgcaagatctgcgtgcggcaagtggaaggggagggccag
atattccagctgcataccactctggcagagacacctgctggctccctggacactctctgc
tctgcccctggcagcactgtcaccacccagctgggaccttatgccttcaagatcccactg
tccatccgccagaagatatgcaacagcctagatgcccccaactcacggggcaatgactgg
cggatgttagcacagaagctctctatggaccggtacctgaattactttgccaccaaagcg
agccccacgggtgtgatcctggacctctgggaagctctgcagcaggacgatggggacctc
aacagcctggcgagtgccttggaggagatgggcaagagtgagatgctggtggctgtggcc
accgacggggactgctga

Protein Sequence

>219699 : length: 945
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV
KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL
FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV
PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT
VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP
VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL
SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG
FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL
KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD
PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV
LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP
CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT
PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY
HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC
SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA
SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC



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