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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 219699 |
Name | UNC5B |
Synonym | UNC5H2|p53RDL1;unc-5 homolog B (C. elegans);UNC5B;unc-5 homolog B (C. elegans) |
Definition | netrin receptor UNC5B|p53-regulated receptor for death and life protein 1|protein unc-5 homolog 2|protein unc-5 homolog B|transmembrane receptor Unc5H2|unc-5 homolog 2 |
Position | 10q22.1 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "UNC5B acts as a tumor suppressor, and it induces apoptosis in the absence of its cognate ligand netrins. UNC5B is a direct transcriptional target of p53 upon UV stimulation." |
potential | UNC5H may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis. |
| More detail of all 2 literatures about UNC5B | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Netrin-1 signaling;PID Reactome;500088 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Role of DCC in regulating apoptosis;PID Reactome;500280 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | PSYCH;GAD |
Disease | attention-deficit hyperactivity disorder;GAD |
Disease | Cancer;FunDO |
Disease | ADHD;GAD |
Disease | Attention deficit hyperactivity disorder;NHGRI |
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External Links |
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Links to Entrez Gene | 219699 |
Links to all GeneRIF Items | 219699 |
Links to iHOP | 219699 |
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Sequence Information |
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Nucleotide Sequence |
>219699 : length: 2838 atgggggcccggagcggagctcggggcgcgctgctgctggcactgctgctctgctgggac ccgaggctgagccaagcaggcactgattctggcagcgaggtgctccctgactccttcccg tcagcgccagcagagccgctgccctacttcctgcaggagccacaggacgcctacattgtg aagaacaagcctgtggagctccgctgccgcgccttccccgccacacagatctacttcaag tgcaacggcgagtgggtcagccagaacgaccacgtcacacaggaaggcctggatgaggcc accggcctgcgggtgcgcgaggtgcagatcgaggtgtcgcggcagcaggtggaggagctc tttgggctggaggattactggtgccagtgcgtggcctggagctccgcgggcaccaccaag agtcgccgagcctacgtccgcatcgcctacctgcgcaagaacttcgatcaggagcctctg ggcaaggaggtgcccctggaccatgaggttctcctgcagtgccgcccgccggagggggtg cctgtggccgaggtggaatggctcaagaatgaggatgtcatcgaccccacccaggacacc aacttcctgctcaccatcgaccacaacctcatcatccgccaggcccgcctgtcggacact gccaactatacctgcgtggccaagaacatcgtggccaaacgccggagcaccactgccacc gtcatcgtctacgtgaatggcggctggtccagctgggcagagtggtcaccctgctccaac cgctgtggccgaggctggcagaagcgcacccggacctgcaccaaccccgctccactcaac ggaggggccttctgcgagggccaggcattccagaagaccgcctgcaccaccatctgccca gtcgatggggcgtggacggagtggagcaagtggtcagcctgcagcactgagtgtgcccac tggcgtagccgcgagtgcatggcgcccccaccccagaacggaggccgtgactgcagcggg acgctgctcgactctaagaactgcacagatgggctgtgcatgcaaaataagaaaactcta agcgaccccaacagccacctgctggaggcctcaggggatgcggcgctgtatgcggggctc gtggtggccatcttcgtggtcgtggcaatcctcatggcggtgggggtggtggtgtaccgc cgcaactgccgtgacttcgacacagacatcactgactcatctgctgccctgactggtggt ttccaccccgtcaactttaagacggcaaggcccagcaacccgcagctcctacacccctct gtgcctcctgacctgacagccagcgccggcatctaccgcggacccgtgtatgccctgcag gactccaccgacaaaatccccatgaccaactctcctctgctggaccccttacccagcctt aaggtcaaggtctacagctccagcaccacgggctctgggccaggcctggcagatggggct gacctgctgggggtcttgccgcctggcacataccctagcgatttcgcccgggacacccac ttcctgcacctgcgcagcgccagcctcggttcccagcagctcttgggcctgccccgagac ccagggagcagcgtcagcggcacctttggctgcctgggtgggaggctcagcatccccggc acaggggtcagcttgctggtgcccaatggagccattccccagggcaagttctacgagatg tatctactcatcaacaaggcagaaagtaccctcccgctttcagaagggacccagacagta ttgagcccctcggtgacctgtggacccacaggcctcctgctgtgccgccccgtcatcctc accatgccccactgtgccgaagtcagtgcccgtgactggatctttcagctcaagacccag gcccaccagggccactgggaggaggtggtgaccctggatgaggagaccctgaacacaccc tgctactgccagctggagcccagggcctgtcacatcctgctggaccagctgggcacctac gtgttcacgggcgagtcctattcccgctcagcagtcaagcggctccagctggccgtcttc gcccccgccctctgcacctccctggagtacagcctccgggtctactgcctggaggacacg cctgtagcactgaaggaggtgctggagctggagcggactctgggcggatacttggtggag gagccgaaaccgctaatgttcaaggacagttaccacaacctgcgcctctccctccatgac ctcccccatgcccattggaggagcaagctgctggccaaataccaggagatccccttctat cacatttggagtggcagccagaaggccctccactgcactttcaccctggagaggcacagc ttggcctccacagagctcacctgcaagatctgcgtgcggcaagtggaaggggagggccag atattccagctgcataccactctggcagagacacctgctggctccctggacactctctgc tctgcccctggcagcactgtcaccacccagctgggaccttatgccttcaagatcccactg tccatccgccagaagatatgcaacagcctagatgcccccaactcacggggcaatgactgg cggatgttagcacagaagctctctatggaccggtacctgaattactttgccaccaaagcg agccccacgggtgtgatcctggacctctgggaagctctgcagcaggacgatggggacctc aacagcctggcgagtgccttggaggagatgggcaagagtgagatgctggtggctgtggcc accgacggggactgctga |
Protein Sequence |
>219699 : length: 945 MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC |