Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2308

Name

FOXO1

Synonym

FKH1|FKHR|FOXO1A;forkhead box O1;FOXO1;forkhead box O1

Definition

forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma

Position

13q14.1

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,TAG,Generif

Literature support

Count: 2 PubMed records as below.

Evidence Status

Description

reviewed

FOXO1 serves as a tumor suppressor in endometrial cancer cells and is involved in normal growth control and maintenance of genomic stability.

potential

FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer.
More detail of all 2 literatures about FOXO1

Pathways and Diseases

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

Class I PI3K signaling events mediated by Akt;PID Curated;200169

Pathway

Signaling events mediated by HDAC Class III;PID Curated;200020

Pathway

AKT-mediated inactivation of FOXO1A;PID Reactome;500523

Pathway

Regulation of Androgen receptor activity;PID Curated;200102

Pathway

Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066

Pathway

Regulation of nuclear SMAD2/3 signaling;PID Curated;200002

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

CXCR4-mediated signaling events;PID Curated;200083

Pathway

IL6-mediated signaling events;PID Curated;200124

Pathway

FoxO family signaling;PID Curated;200091

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Regulation of beta-cell development;Reactome;REACT:13698

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Regulation of gene expression in beta cells;PID Reactome;500522

Disease

Cancers;KEGG DISEASE

Disease

Rhabdomyosarcoma, alveolar;OMIM

Disease

Prostate cancer;FunDO

Disease

Muscular atrophy;FunDO

Disease

Cancers of soft tissues and bone;KEGG DISEASE

Disease

Leukemia;FunDO

Disease

Congenital abnormality;FunDO

Disease

Alveolar rhabdomyosarcoma;KEGG DISEASE;H00037

Disease

Central corneal thickness;NHGRI

External Links

Links to Entrez Gene

2308

Links to all GeneRIF Items

2308

Links to iHOP

2308

Sequence Information

Nucleotide Sequence

>2308 : length: 1968
atggccgaggcgcctcaggtggtggagatcgacccggacttcgagccgctgccccggccg
cgctcgtgcacctggccgctgcccaggccggagtttagccagtccaactcggccacctcc
agcccggcgccgtcgggcagcgcggctgccaaccccgacgccgcggcgggcctgccctcg
gcctcggctgccgctgtcagcgccgacttcatgagcaacctgagcttgctggaggagagc
gaggacttcccgcaggcgcccggctccgtggcggcggcggtggcggcggcggccgccgcg
gccgccaccggggggctgtgcggggacttccagggcccggaggcgggctgcctgcaccca
gcgccaccgcagcccccgccgcccgggccgctgtcgcagcacccgccggtgccccccgcc
gccgctgggccgctcgcggggcagccgcgcaagagcagctcgtcccgccgcaacgcgtgg
ggcaacctgtcctacgccgacctcatcaccaaggccatcgagagctcggcggagaagcgg
ctcacgctgtcgcagatctacgagtggatggtcaagagcgtgccctacttcaaggataag
ggtgacagcaacagctcggcgggctggaagaattcaattcgtcataatctgtccctacac
agcaagttcattcgtgtgcagaatgaaggaactggaaaaagttcttggtggatgctcaat
ccagagggtggcaagagcgggaaatctcctaggagaagagctgcatccatggacaacaac
agtaaatttgctaagagccgaagccgagctgccaagaagaaagcatctctccagtctggc
caggagggtgctggggacagccctggatcacagttttccaaatggcctgcaagccctggc
tctcacagcaatgatgactttgataactggagtacatttcgccctcgaactagctcaaat
gctagtactattagtgggagactctcacccattatgaccgaacaggatgatcttggagaa
ggggatgtgcattctatggtgtacccgccatctgccgcaaagatggcctctactttaccc
agtctgtctgagataagcaatcccgaaaacatggaaaatcttttggataatctcaacctt
ctctcatcaccaacatcattaactgtttcgacccagtcctcacctggcaccatgatgcag
cagacgccgtgctactcgtttgcgccaccaaacaccagtttgaattcacccagcccaaac
taccaaaaatatacatatggccaatccagcatgagccctttgccccagatgcctatacaa
acacttcaggacaataagtcgagttatggaggtatgagtcagtataactgtgcgcctgga
ctcttgaaggagttgctgacttctgactctcctccccataatgacattatgacaccagtt
gatcctggggtagcccagcccaacagccgggttctgggccagaacgtcatgatgggccct
aattcggtcatgtcaacctatggcagccaggcatctcataacaaaatgatgaatcccagc
tcccatacccaccctggacatgctcagcagacatctgcagttaacgggcgtcccctgccc
cacacggtaagcaccatgccccacacctcgggtatgaaccgcctgacccaagtgaagaca
cctgtacaagtgcctctgccccaccccatgcagatgagtgccctggggggctactcctcc
gtgagcagctgcaatggctatggcagaatgggccttctccaccaggagaagctcccaagt
gacttggatggcatgttcattgagcgcttagactgtgacatggaatccatcattcggaat
gacctcatggatggagatacattggattttaactttgacaatgtgttgcccaaccaaagc
ttcccacacagtgtcaagacaacgacacatagctgggtgtcaggctga

Protein Sequence

>2308 : length: 655
MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPS
ASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHP
APPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKR
LTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN
PEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPG
SHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLP
SLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPN
YQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPV
DPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLP
HTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPS
DLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved
Site Policies | State of Texas