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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2308 |
Name | FOXO1 |
Synonym | FKH1|FKHR|FOXO1A;forkhead box O1;FOXO1;forkhead box O1 |
Definition | forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma |
Position | 13q14.1 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | FOXO1 serves as a tumor suppressor in endometrial cancer cells and is involved in normal growth control and maintenance of genomic stability. |
potential | FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. |
| More detail of all 2 literatures about FOXO1 | |
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Pathways and Diseases |
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Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | AKT-mediated inactivation of FOXO1A;PID Reactome;500523 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Regulation of beta-cell development;Reactome;REACT:13698 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Regulation of gene expression in beta cells;PID Reactome;500522 |
Disease | Cancers;KEGG DISEASE |
Disease | Rhabdomyosarcoma, alveolar;OMIM |
Disease | Prostate cancer;FunDO |
Disease | Muscular atrophy;FunDO |
Disease | Cancers of soft tissues and bone;KEGG DISEASE |
Disease | Leukemia;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Alveolar rhabdomyosarcoma;KEGG DISEASE;H00037 |
Disease | Central corneal thickness;NHGRI |
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External Links |
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Links to Entrez Gene | 2308 |
Links to all GeneRIF Items | 2308 |
Links to iHOP | 2308 |
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Sequence Information |
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Nucleotide Sequence |
>2308 : length: 1968 atggccgaggcgcctcaggtggtggagatcgacccggacttcgagccgctgccccggccg cgctcgtgcacctggccgctgcccaggccggagtttagccagtccaactcggccacctcc agcccggcgccgtcgggcagcgcggctgccaaccccgacgccgcggcgggcctgccctcg gcctcggctgccgctgtcagcgccgacttcatgagcaacctgagcttgctggaggagagc gaggacttcccgcaggcgcccggctccgtggcggcggcggtggcggcggcggccgccgcg gccgccaccggggggctgtgcggggacttccagggcccggaggcgggctgcctgcaccca gcgccaccgcagcccccgccgcccgggccgctgtcgcagcacccgccggtgccccccgcc gccgctgggccgctcgcggggcagccgcgcaagagcagctcgtcccgccgcaacgcgtgg ggcaacctgtcctacgccgacctcatcaccaaggccatcgagagctcggcggagaagcgg ctcacgctgtcgcagatctacgagtggatggtcaagagcgtgccctacttcaaggataag ggtgacagcaacagctcggcgggctggaagaattcaattcgtcataatctgtccctacac agcaagttcattcgtgtgcagaatgaaggaactggaaaaagttcttggtggatgctcaat ccagagggtggcaagagcgggaaatctcctaggagaagagctgcatccatggacaacaac agtaaatttgctaagagccgaagccgagctgccaagaagaaagcatctctccagtctggc caggagggtgctggggacagccctggatcacagttttccaaatggcctgcaagccctggc tctcacagcaatgatgactttgataactggagtacatttcgccctcgaactagctcaaat gctagtactattagtgggagactctcacccattatgaccgaacaggatgatcttggagaa ggggatgtgcattctatggtgtacccgccatctgccgcaaagatggcctctactttaccc agtctgtctgagataagcaatcccgaaaacatggaaaatcttttggataatctcaacctt ctctcatcaccaacatcattaactgtttcgacccagtcctcacctggcaccatgatgcag cagacgccgtgctactcgtttgcgccaccaaacaccagtttgaattcacccagcccaaac taccaaaaatatacatatggccaatccagcatgagccctttgccccagatgcctatacaa acacttcaggacaataagtcgagttatggaggtatgagtcagtataactgtgcgcctgga ctcttgaaggagttgctgacttctgactctcctccccataatgacattatgacaccagtt gatcctggggtagcccagcccaacagccgggttctgggccagaacgtcatgatgggccct aattcggtcatgtcaacctatggcagccaggcatctcataacaaaatgatgaatcccagc tcccatacccaccctggacatgctcagcagacatctgcagttaacgggcgtcccctgccc cacacggtaagcaccatgccccacacctcgggtatgaaccgcctgacccaagtgaagaca cctgtacaagtgcctctgccccaccccatgcagatgagtgccctggggggctactcctcc gtgagcagctgcaatggctatggcagaatgggccttctccaccaggagaagctcccaagt gacttggatggcatgttcattgagcgcttagactgtgacatggaatccatcattcggaat gacctcatggatggagatacattggattttaactttgacaatgtgttgcccaaccaaagc ttcccacacagtgtcaagacaacgacacatagctgggtgtcaggctga |
Protein Sequence |
>2308 : length: 655 MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPS ASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHP APPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKR LTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN PEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPG SHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLP SLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPN YQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPV DPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLP HTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPS DLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG |