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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 2308 |
Name | FOXO1 |
Synonymous | FKH1|FKHR|FOXO1A;forkhead box O1;FOXO1;forkhead box O1 |
Definition | forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma |
Position | 13q14.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
FOXO1A(h) + ATP --SGK-1(h)--> FOXO1A(h){p} + ADP (phosphorylation) | FOXO1A(h) + ATP --AKT-1(h)--> FOXO1A(h){p} + ADP (phosphorylation) | AKT-1(h) + FOXO1A(h) <==> FOXO1A(h):AKT-1(h) (binding) | FOXO1A(h) + ATP --AKT-1(m)--> FOXO1A(h){p} + ADP (phosphorylation) | FOXO1A(h) --> IGFBP1(h) (DNA binding; transactivation) | FOXO1A(h) --> G6PC(h) (DNA binding; transactivation). | AR(h) + FOXO1A(h) <==> AR(h):FOXO1A(h) (binding) | FOXO1A(h) --> PDK4(h) (DNA binding; transactivation). | FOXO1A(h) + acetyl-CoA --p300(h)--> FOXO1A(h){ace} + CoA (acetylation) | FOXO1A(h) + p300(h) <==> FOXO1A(h):p300(h) (binding) | ER-alpha(h) + FOXO1A(h) <==> ER-alpha(h):FOXO1A(h) (binding) | T3R-beta(h) + FOXO1A(h) <==> T3R-beta(h):FOXO1A(h) (binding) | FOXO1A(h) + NR1B1(h) <==> FOXO1A(h):NR1B1(h) (binding) | FOXO1A(h) + 4 UDP-GlcNAc --> FOXO1A(h){glyT317}{glyS550}{glyT648}{glyS656} + 4 UDP (O-glycosylation) | FOXO1A(h) --> G6pc(m) (transactivation) | RBPJK(m.s.) + FOXO1A(h) <==> RBPJK(m.s.):FOXO1A(h) (binding) | FOXO1A(h) + 3 ATP --AKT-1(h){pT308}{pS473}--> FOXO1A(h){pT24}{pS256}{pS319} + 3 ADP (phosphorylation) | FOXO1A(h) + 3 ATP --AKT-1(h)--> FOXO1A(h){pT24}{pS256}{pS319} + 3 ADP (phosphorylation) | FOXO1A(h) + ATP --> FOXO1A(h){pS329} + ADP (phosphorylation) | FOXO1A(h) + 2 ATP --> FOXO1A(h){pT24}{pS329} + 2 ADP (phosphorylation) | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1A(h) + ATP --dyrk1a(rb){p}--> FOXO1A(h){pS329} + ADP (phosphorylation) | FOXO1A(h) + ATP --Dyrk1A(r)--> FOXO1A(h){pS329} + ADP (phosphorylation) | FOXO1A(h) + ATP --cyclinB(m.s.):Cdk1(m.s.)--> FOXO1A(h){pS249} + ADP (phosphorylation) | FOXO1A(h) + ATP --> FOXO1A(h){pS256} + ADP (phosphorylation) | FOXO1A(h) + 14-3-3(h) <==> FOXO1A(h):14-3-3(h) (binding) | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1A(h) + ATP --> FOXO1A(h){pS249} + ADP (phosphorylation) | FOXO1A(h) --> Bim(r) (increase of abundance) | FOXO1A(h) --> Pck1(r) (DNA binding). | FOXO1A(h) --> TAT(r) (DNA binding). | FOXO1(h) --> FOXO1A(h) (expression). | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1A(h) + ATP --WISK(r){p}--> FOXO1A(h){p} + ADP (phosphorylation) | FOXO1A(h) + ATP --AKT-1(h){pT308}{pS473}--> FOXO1A(h){p} + ADP (phosphorylation) | smad4(h) + FOXO1A(h) <==> smad4(h):FOXO1A(h) (binding) | FOXO1A(h) + Skp2(h) <==> FOXO1A(h):Skp2(h) (binding) | FOXO1A(h) + Slim-3(h) <==> FOXO1A(h):Slim-3(h) (binding) | CBP(h) + FOXO1A(h) <==> CBP(h):FOXO1A(h) (binding) | SIRT1(h) + FOXO1A(h) <==> SIRT1(h):FOXO1A(h) (binding) | FOXO1A(h) + ATP --> FOXO1A(h){p} + ADP (phosphorylation) | FOXO1A(h) --> IGFBP1(h) (DNA binding). | FOXO1A(h) + ATP --> FOXO1A(h){pT24} + ADP (phosphorylation) | FOXO1A(h) + ATP --AMPKalpha(h){pT}--> FOXO1A(h){p} + ADP (phosphorylation) | FOXO1A(h) --> ANG2(h) (increase of abundance) | FOXO1A(h) --> HES1(h) (transactivation) | FOXO1A(h) + 2 ATP --> FOXO1A(h){pT24}{pS329} + 2 ADP (phosphorylation) | Dyrk1A(r) + FOXO1A(h) <==> Dyrk1A(r):FOXO1A(h) (binding) | FOXO1A(h) + ATP --> FOXO1A(h){pS249} + ADP (phosphorylation) | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1A(h) --> ABCB1(h) (DNA binding; transactivation). | FOXO1A(h) --> PPARGC1A(h) (DNA binding). | FOXO1(h) --> FOXO1A(h) (expression). | FOXO1A(h) --> FOXO1A(h) (translocation) | FOXO1(h) --> FOXO1(h) (expression). | hsa-miR-27a --/ FOXO1(h) (translational repression). | hsa-miR-96 --/ FOXO1(h) (translational repression). | hsa-miR-182 --/ FOXO1(h) (translational repression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
24 | Phosphothreonine (by PKB/AKT1). | Swiss-Prot 53.0 | 256 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 319 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 329 | Phosphoserine (by DYRK1A). | Swiss-Prot 53.0 | 467 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 468 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 329 | Phosphoserine (DYRK1A) | 11311120 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr13 |
Promoter: 40138234 - 40140234 | GSE27584 |
chr13 |
Promoter: 40138234 - 40140234 | Agilent_014791_44K |
chr13 |
Promoter: 40138234 - 40140234 | Agilent_014791 |