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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 23239 |
Name | PHLPP1 |
Synonym | PHLPP|PLEKHE1|SCOP;PH domain and leucine rich repeat protein phosphatase 1;PHLPP1;PH domain and leucine rich repeat protein phosphatase 1 |
Definition | PH domain leucine-rich repeat-containing protein phosphatase 1|PH domain-containing family E member 1|SCN circadian oscillatory protein|pleckstrin homology domain containing, family E (with leucine rich repeats) member 1|suprachiasmatic nucleus circadian |
Position | 18q21.33 |
Gene Type | protein-coding |
Source | Count: 2; UniProt,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. |
reviewed | "PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma." |
reviewed | Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells. |
| More detail of all 3 literatures about PHLPP1 | |
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Pathways and Diseases |
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Pathway | Signalling by NGF;Reactome;REACT:11061 |
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External Links |
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Links to Entrez Gene | 23239 |
Links to all GeneRIF Items | 23239 |
Links to iHOP | 23239 |
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Sequence Information |
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Nucleotide Sequence |
>23239 : length: 5154 atggagcccgccgccgcggccacggtacagcgactccccgagctcggcagggaggaccga gcttcggctccggcggccgccgctgcggcagcagcagcagcagcggcggccgcggcggct ctggcggcggcggccgggggcggccggagtccggagcccgcgctgaccccggcggccccg agcggcgggaacggcagcggcagcggggcgcgggaagaggccccaggcgaggcgccgccg gggccgctgccgggcagagcggggggtgccgggcgcaggaggcggcgcggggcgccccag cccattgccggcggggctgcccccgtacccggggccggcggcggcgccaactccctcctg ctgaggagagggcggctgaagaggaatctgtccgcggccgccgcggccgcctcctcgtcg tcgtcgtcctcggccgctgctgcctcgcactcccccggcgctgccggcctccccgcctcc tgctcggcctcggcgtcgctgtgcacccggagcctggacaggaagacgctgcttctgaag caccggcagacgctgcagctgcagccgtcggaccgggactgggtgaggcaccagctccag cgcggctgcgtgcacgtcttcgaccgccacatggcctcgacctacctgcgcccggtgctc tgcacactggacaccacggccggcgaggtggccgcccgcctgctgcagctgggccacaaa ggcggcggcgtggtgaaggtgctgggccaggggcccggagccgccgccgcccgggagccc gctgaaccgccccccgaggccggcccccggctggcgcccccggagccgcgggactcggag gtaccgcccgcgaggagcgcgccgggtgccttcggggggcctccgcgcgcgccccccgcc gacctacccctgcccgtcggcggcccgggcgggtggtcgcgccgcgccagcccagcgccc tcggactccagccccggcgagccgttcgttgggggccctgtctcttcgccccgcgcccca cggcctgtggtctccgacaccgagagcttcagtctgagtcccagcgccgagagcgtgtct gaccggttggacccctacagcagcggcggcggctcctcgtcgtcgtcggaagagctcgag gccgacgcagcctcggccccgacgggggtcccgggccagccccgccgtcccggccacccc gcgcagcccctcccgcttccccagacggcttcctcgcctcagccgcagcagaaagccccg agggccattgacagcccgggcggggccgtccgcgaggggtcgtgcgaggagaaggcagcg gcagccgtggccccgggaggcctccagtctacccccgggaggagcggggtgaccgcggag aaggcgcctccgccgcccccgccgcccaccctgtacgtgcagctccacggagagaccacc cggcgcttggaggcggaggagaagccattgcagatccaaaatgactacctcttccaactg ggatttggggagctgtggagggtgcaggaggaaggcatggactcggagattggctgcctc atccgcttctatgcaggaaaacctcacagcacgggtagctctgaacggattcagctctca ggaatgtataatgtccgtaaaggcaagatgcagttgccagtgaaccgatggacaagacgc caagtcatcctatgtgggacctgcctgatagtatcatctgtgaaagacagcttgaccgga aagatgcatgttctgccactaattggtggaaaagtagaagaagtgaaaaagcaccaacac tgtttagcatttagctcctctggaccccaaagccagacttactacatttgctttgatact ttcacagaatacttaaggtggctgcgacaagtctccaaggttgcatcccagcgcattagc tcagtggacctctcgtgttgtagcctggaacatctgcctgccaacctcttctacagccaa gacctcactcatctcaatttaaaacaaaacttcctaaggcagaaccctagccttccagct gccagggggcttaatgaactgcaaaggttcaccaagttgaagagtcttaacctttccaat aatcatttaggggacttcccactggcagtctgcagtattccaaccctggcagagctgaac gtgtcctgcaatgccctgcgatcagtcccggcagccgttggagtgatgcacaacttacag acatttttgttggatggaaactttctccaatcccttcctgctgagttggagaacatgaag cagcttagttatctgggtctttctttcaatgaatttactgacattcccgaagtattggag aaattgactgctgtggataaactttgtatgtctggaaactgtgtggagacccttaggcta caggctttaagaaaaatgcctcacattaaacatgtggatctaaggttgaacgtaattagg aagctgatagcagatgaagtggactttctacagcatgttactcagcttgacctacgagac aataagcttggtgatctagatgctatgattttcaacaacattgaagttttacactgtgaa aggaatcaactggtcacattagacatctgtggctatttcctaaaagcgctctatgcctct tctaatgaacttgttcaacttgatgtttacccagttccaaattatctgtcctacatggat gtttcaaggaaccgcttagaaaatgtgcctgagtgggtatgtgaaagccgaaagctagaa gttttggatattggccataatcaaatatgtgaacttcctgcccgcttattttgtaatagc agtctccggaaactactggcaggacacaaccagttggcaaggctgcctgaaaggctagaa agaacctcggtggaggtcttggatgtgcaacacaaccagctccttgagctcccacctaac cttctgatgaaggctgacagcctgagattcctgaacgcctctgcgaacaaactggaaagc cttcctccagccacgctttccgaagagacaaacagtatcttacaagagttgtatttgaca aataacagcctcacagacaaatgtgtgcccttgttaacgggacacccccatttgaagatc cttcacatggcctataaccgacttcagagttttccagcaagtaaaatggcgaaactggag gaacttgaagaaattgatctcagtgggaataagctgaaagccatcccaacaacgatcatg aattgcaggcgcatgcacaccgtgattgctcactccaactgcatcgaggtctttcccgaa gttatgcagctcccagagatcaagtgtgtggacctgagctgtaatgagctaagtgaagtc acattaccagaaaacctgcctcccaaactgcaggagctagacctgactggaaacccgcgc cttgtccttgatcacaaaaccctggaactactgaataatatccgctgtttcaagattgat cagccttctacaggagacgcttccggagccccagctgtatggagtcatggttacactgaa gcttcgggggtaaaaaacaagttgtgtgtcgcagccctgtcggtgaataacttctgtgac aaccgcgaagccctgtatggtgtgtttgacggagaccggaatgtggaggtgccctacctt ctccagtgcactatgagtgacattttggctgaagagctgcaaaaaacaaaaaacgaagaa gaatacatggtcaatacattcattgtcatgcaaaggaaacttggaactgctgggcagaag cttggtggtgccgctgtcctttgtcatatcaagcatgaccctgtggatccaggaggatcc ttcaccttgacctctgctaatgtgggcaagtgccaaacagttctctgtcgaaatggaaag ccgctgcctctgtccagatcttacatcatgagctgtgaagaagagctgaagaggattaaa cagcacaaggccattatcactgaggatggcaaggtgaacggagtgactgagtccacgcgc atcctgggctacaccttcctccatcccagtgtggtgcctcgcccccacgtgcagtccgtg ctcctgactccccaggatgagttcttcatcctaggcagtaaggggttgtgggacagcctg tccgtcgaggaggccgtggaagccgtgcgcaacgtgcccgatgccctggctgctgccaag aagctgtgtaccctggcccagagctacggctgccacgacagcatcagcgctgtggtggtg cagctcagtgtcactgaggacagcttctgctgctgcgagctcagcgccggtggggctgtg ccaccacccagtcctggcatctttcctccctcagtgaacatggtgatcaaggatcggccc tcagatgggctgggcgtgccgtcctccagcagcggcatggcttccgagattagcagtgag ctctccacttctgagatgagcagcgaggtggggtcaacagcctccgatgagcccccgccc ggagccctaagcgagaacagccctgcctaccccagtgagcagcgctgcatgctccacccc atctgtctgtccaactccttccagcgccagctatccagcgccacgttctctagcgccttc tccgacaacggccttgacagtgacgatgaggagcccatcgagggcgtcttcaccaacggc agccgggtggaggtggaggtggacatccactgcagccgggccaaggagaaggagaaacag cagcacctgcttcaggtgccagcagaggccagtgatgagggcattgtcatcagcgccaac gaggatgagccaggtctgcccaggaaggcagacttctctgccgttgggaccattgggcgc cggagggccaatggctctgttgcgccccaggaaaggagccacaatgtgatagaggtggct acagacgcacctcttcgaaagcctggaggctattttgctgccccggctcagccggatcct gatgatcagtttatcatacccccggagctggaagaggaggtcaaagaaatcatgaagcat caccaggagcaacagcagcagcagcagccgccaccaccccctcagctccagccgcagctg ccgcggcactaccagctggaccagctgccagattattacgacacgccactatga |
Protein Sequence |
>23239 : length: 1717 MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL |